在绿色反应条件下以柠檬汁为均相天然催化剂合成 5-取代的-1H-四唑

IF 3.2 4区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY Journal of the Indian Chemical Society Pub Date : 2024-09-19 DOI:10.1016/j.jics.2024.101382
Mohammad Valipour, Setareh Habibzadeh, Masoumeh Taherimehr
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引用次数: 0

摘要

四氮唑作为一种杂环化合物,在各行各业都有广泛的应用。本研究的重点是利用天然催化剂合成四氮唑衍生物。我们利用柠檬汁(LJ)的酸性,将其作为合成 5-取代-1H-四氮唑的潜在催化剂。柠檬汁也可作为反应介质。该合成涉及叠氮化钠与苯甲腈在无溶剂条件下的环化反应(3 + 2)。考虑到反应时间较短,对反应条件(包括温度、反应时间和溶剂类型)进行了优化,以获得最高产率。在无额外溶剂的条件下,反应温度为 90 °C,反应时间为 40 分钟,产品收率最高(97%)。在优化的反应条件下,对各种苯腈衍生物进行了检验。
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Synthesis of 5-substituted-1H-tetrazoles by lemon juice as a homogeneous and natural catalyst under green reaction conditions
Tetrazole, as a heterocyclic compound, exhibits a wide spectrum of applications in various industries. This research focuses on utilizing a natural catalyst in the synthesis of tetrazole derivatives. Leveraging the acidic nature of lemon juice (LJ), we employed it as a potential catalyst in the synthesis of 5-substituted-1H-tetrazole. LJ would act as the reaction medium as well. This synthesis involves the cycloaddition reaction (3 + 2) of sodium azide to benzonitrile under solvent-free conditions. Optimization of the reaction conditions including temperature, reaction time, and solvent type was tuned towards the highest yield considering the mild reaction time. The best product yield (97 %) was obtained at 90 °C, 40 min, in the absence of additional solvent. Various benzonitrile derivatives were examined at the optimized reaction condition.
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来源期刊
CiteScore
3.50
自引率
7.70%
发文量
492
审稿时长
3-8 weeks
期刊介绍: The Journal of the Indian Chemical Society publishes original, fundamental, theorical, experimental research work of highest quality in all areas of chemistry, biochemistry, medicinal chemistry, electrochemistry, agrochemistry, chemical engineering and technology, food chemistry, environmental chemistry, etc.
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