没药树胶对致病性念珠菌的抗真菌活性

IF 1.3 4区 医学 Q4 ENVIRONMENTAL SCIENCES Annals of Agricultural and Environmental Medicine Pub Date : 2024-09-25 Epub Date: 2024-09-06 DOI:10.26444/aaem/192095
Amira H Alabdalall
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引用次数: 0

摘要

引言和目的:药用植物的疗效由来已久。阿拉伯南部的没药就是一个有名的例子。本研究的目的是评估从两种不同品种的没药中提取的水基提取物在不同浓度下抑制念珠菌属增殖的有效性:采用扩散技术评估了两种不同品种的没药水提取物对五种病原性酵母菌的抑制活性。质谱用于分析没药抗菌作用的化学成分:结果:两种受测没药(Commiphora myrrha 和 Commiphora molmol)的水提取物对所有受测分离菌都有抑制作用。在对没药进行化学检查时发现,没药中含有 12 种具有抗菌特性的成分。从两个品种的没药中提取的精油对热带念珠菌(ATCC 66029)、吉利蒙地念珠菌(ATCC 6260)、月桂念珠菌(ATCC 18803)、新变形念珠菌(ATCC 66031)和白念珠菌(ATCC 14053)有最显著的抑制作用。对没药化学成分的分析显示出 19 种已知成分,其中 12 种化合物已被研究证实能抑制微生物的生长:结论:C. myrha 和 C. molmol 水提取物对常见的念珠菌感染有很好的抗真菌效果。水提取物中含有多种抗菌化合物;不过,在考虑将其应用于临床之前,有必要开展进一步研究,以阐明这些化合物的具体作用机制,并评估其功效、毒性和安全性。
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Antifungal activity of Myrrh gum resin against pathogenic Candida spp.

Introduction and objective: Medicinal plants have a long and significant history of being used for their healing properties. One famous example is Commiphora, which is mostly found in the southern part of Arabia. The objective of this study was to evaluate the effectiveness of a water-based extract obtained from two different varieties of myrrh in suppressing the proliferation of Candida spp. at different concentrations.

Material and methods: The inhibitory activity of the aqueous extract of two different varieties of myrrh, commonly used in traditional medicine, was assessed against five pathogenic yeasts using the diffusion technique. Mass spectrum was used to analyze myrrh's chemical composition for antimicrobial effects.

Results: The aqueous extract of both tested species of myrrh (Commiphora myrrha and Commiphora molmol) showed inhibitory effects on all tested isolates. During the chemical examination of myrrh, it was noted that the material included 12 components known for their antimicrobial properties. The essential oil derived from two varieties of myrrh showed the most significant effects on Candida tropicalis (ATCC 66029), Candida guilliermondii (ATCC 6260), Candida laurentii (ATCC 18803), Candida neoformans (ATCC 66031), and Candida albicans (ATCC 14053). Analysis of chemical composition of the myrrh revealed 19 known components, of which 12 compounds have been proven by research to suppress the growth of microorganisms.

Conclusions: C. myrrha and C. molmol aqueous extracts exhibit a promising antifungal effect against common Candida infections. The aqueous extracts present a variety of antimicrobial compounds; however, further research is necessary to elucidate the specific mechanisms of action of these compounds, and to evaluate their efficacy, toxicity and safety before considering their clinical application.

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来源期刊
Annals of Agricultural and Environmental Medicine
Annals of Agricultural and Environmental Medicine 医学-公共卫生、环境卫生与职业卫生
CiteScore
3.00
自引率
5.90%
发文量
58
审稿时长
4-8 weeks
期刊介绍: All papers within the scope indicated by the following sections of the journal may be submitted: Biological agents posing occupational risk in agriculture, forestry, food industry and wood industry and diseases caused by these agents (zoonoses, allergic and immunotoxic diseases). Health effects of chemical pollutants in agricultural areas , including occupational and non-occupational effects of agricultural chemicals (pesticides, fertilizers) and effects of industrial disposal (heavy metals, sulphur, etc.) contaminating the atmosphere, soil and water. Exposure to physical hazards associated with the use of machinery in agriculture and forestry: noise, vibration, dust. Prevention of occupational diseases in agriculture, forestry, food industry and wood industry. Work-related accidents and injuries in agriculture, forestry, food industry and wood industry: incidence, causes, social aspects and prevention. State of the health of rural communities depending on various factors: social factors, accessibility of medical care, etc.
期刊最新文献
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