睡眠呼吸暂停对心血管健康和死亡率的影响分析:一项长期队列研究

IF 0.7 Q4 PHARMACOLOGY & PHARMACY Journal of pharmacy & bioallied sciences Pub Date : 2024-07-01 Epub Date: 2024-07-31 DOI:10.4103/jpbs.jpbs_390_24
Riddhi Chawla, Abhishek Jahagirdar, Happy Riba, Tharini Satheesh, Pratiksha Somwanshi, Shiba Brata Behera, Sunil K Gulia
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引用次数: 0

摘要

背景:睡眠呼吸暂停(SL)"是一种常见的睡眠问题,与心血管疾病和死亡有关。然而,人们对睡眠呼吸暂停如何长期影响心血管健康知之甚少。本研究的目的是调查一家三级医疗中心的长期队列心血管发病率和死亡率与睡眠呼吸暂停严重程度之间的关系:方法:2010 年 1 月 1 日至 2020 年 12 月 31 日期间,一家三级医疗机构的 500 名被诊断为 SL 的患者参与了这项回顾性队列研究。研究人员使用电子病历收集患者数据,然后对这些数据进行检查,包括心血管结果、治疗方法、合并症、睡眠研究结果和人口统计学特征。心力衰竭、心肌梗死、中风和心血管相关死亡率是整个随访期间发现的心血管事件,而睡眠障碍的严重程度则根据 "呼吸暂停-低通气指数 "进行分类:在500名患者中,60%为男性,平均年龄为55.7岁。50%的人有一个或多个心血管风险因素,包括糖尿病、高血压和吸烟。在随访过程中,共报告了 100 例心血管相关死亡病例,40% 的患者至少发生过一次心血管事件。SL的严重程度与心血管事件的发生呈正相关(轻度SL为16.7%,中度SL为25%,重度SL为40%,P<0.05):这项研究显示,在接受三级护理的一组患者中,SL 的严重程度与心血管疾病的发病率和死亡率之间存在着很大的相关性。早期识别和治疗 SL 对降低心血管风险和改善患者预后至关重要。为了进一步了解心血管并发症和 SL 的基本过程并开发治疗方法,有必要开展更多的研究。
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Analysis of the Impact of Sleep Apnea on Cardiovascular Health and Mortality: A Long-Term Cohort Study.

Background: A common sleep problem linked to poor cardiovascular outcomes and death is "sleep apnea (SL)." Nevertheless, little is known about how SL affects cardiovascular health in the long run. The purpose of this research was to investigate the relationship between a tertiary care center's long-term cohort's cardiovascular morbidity and mortality and the severity of their SL.

Methods: Between January 1, 2010, and December 31, 2020, 500 individuals at a tertiary care facility who had been diagnosed with SL participated in this retrospective cohort research. Electronic medical records were used to collect patient data, which were then examined for cardiovascular outcomes, treatment methods, comorbidities, sleep research findings, and demographics. Heart failure, myocardial infarction, stroke, and cardiovascular-related mortality were among the cardiovascular events that were noted throughout the follow-up period, and the severity of SL was classified using the "apnea-hypopnea index."

Findings: Of the 500 patients in the cohort, 60% were men and the mean age was 55.7 years. Fifty percent of people had one or more cardiovascular risk factors, including diabetes, high blood pressure, and smoking. During the course of the follow-up, 100 cardiovascular-related fatalities were reported, and 40% of patients had at least one cardiovascular event. The severity of SL was shown to be positively correlated with the occurrence of cardiovascular events (16.7% in mild, 25% in moderate, and 40% in severe SL, P < 0.05).

Conclusion: In a cohort of patients receiving tertiary care, this research shows a substantial correlation between the severity of SL and cardiovascular morbidity and death. It is crucial to identify and treat SL early on to reduce cardiovascular risks and enhance patient outcomes. To further understand the underlying processes and develop treatment approaches for people with cardiovascular comorbidities and SL, more research is necessary.

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