{"title":"各种牙周骨移植材料体外抗菌性能的比较分析","authors":"Azza A Abushama, Nuha Abdalla Osman","doi":"10.4103/jpbs.jpbs_336_24","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Periodontal bone grafting is a common procedure in dentistry to restore bone loss resulting from periodontal disease. Various graft materials are available, each with different antibacterial properties. Understanding these properties is crucial for successful grafting outcomes.</p><p><strong>Materials and methods: </strong>In this study, we conducted a comparative analysis of the antibacterial properties of four commonly used periodontal bone graft materials: The graft used were A: Hydroxyapatite, B: B TCP, C: Bioactive glass, D: Calcium Phosphate materials. Each material was subjected to <i>in vitro</i> testing using a standardized bacterial culture assay. Antibacterial activity was assessed by measuring the zone of inhibition around each material after exposure to bacterial cultures.</p><p><strong>Results: </strong>Material A exhibited the highest antibacterial activity with an average zone of inhibition of 12.3 mm, followed by Material C with 9.8 mm, Material D with 8.5 mm, and Material B with 6.2 mm. These arbitrary values reflect the relative efficacy of each material in inhibiting bacterial growth.</p><p><strong>Conclusion: </strong>Our findings suggest that Material A possesses the strongest antibacterial properties among the tested periodontal bone graft materials. This may contribute to improved clinical outcomes in periodontal bone grafting procedures by reducing the risk of postoperative infections. Further research is warranted to elucidate the mechanisms underlying the antibacterial effects of these materials and to validate our <i>in vitro</i> findings in clinical settings.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"16 Suppl 3","pages":"S2503-S2505"},"PeriodicalIF":0.7000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11426878/pdf/","citationCount":"0","resultStr":"{\"title\":\"Comparative Analysis of the Antibacterial Properties of Various Periodontal Bone Graft Materials <i>In Vitro</i>.\",\"authors\":\"Azza A Abushama, Nuha Abdalla Osman\",\"doi\":\"10.4103/jpbs.jpbs_336_24\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Periodontal bone grafting is a common procedure in dentistry to restore bone loss resulting from periodontal disease. Various graft materials are available, each with different antibacterial properties. Understanding these properties is crucial for successful grafting outcomes.</p><p><strong>Materials and methods: </strong>In this study, we conducted a comparative analysis of the antibacterial properties of four commonly used periodontal bone graft materials: The graft used were A: Hydroxyapatite, B: B TCP, C: Bioactive glass, D: Calcium Phosphate materials. Each material was subjected to <i>in vitro</i> testing using a standardized bacterial culture assay. Antibacterial activity was assessed by measuring the zone of inhibition around each material after exposure to bacterial cultures.</p><p><strong>Results: </strong>Material A exhibited the highest antibacterial activity with an average zone of inhibition of 12.3 mm, followed by Material C with 9.8 mm, Material D with 8.5 mm, and Material B with 6.2 mm. These arbitrary values reflect the relative efficacy of each material in inhibiting bacterial growth.</p><p><strong>Conclusion: </strong>Our findings suggest that Material A possesses the strongest antibacterial properties among the tested periodontal bone graft materials. This may contribute to improved clinical outcomes in periodontal bone grafting procedures by reducing the risk of postoperative infections. Further research is warranted to elucidate the mechanisms underlying the antibacterial effects of these materials and to validate our <i>in vitro</i> findings in clinical settings.</p>\",\"PeriodicalId\":94339,\"journal\":{\"name\":\"Journal of pharmacy & bioallied sciences\",\"volume\":\"16 Suppl 3\",\"pages\":\"S2503-S2505\"},\"PeriodicalIF\":0.7000,\"publicationDate\":\"2024-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11426878/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of pharmacy & bioallied sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4103/jpbs.jpbs_336_24\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/7/18 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of pharmacy & bioallied sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/jpbs.jpbs_336_24","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/7/18 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0
摘要
背景:牙周骨移植是牙科中一种常见的程序,用于修复因牙周病造成的骨质流失。目前有多种植骨材料,每种材料都具有不同的抗菌特性。了解这些特性对成功的植骨效果至关重要:在这项研究中,我们对四种常用牙周骨移植材料的抗菌性能进行了比较分析:所用植骨材料分别为 A:羟基磷灰石;B:B TCP;C:生物活性玻璃;D:磷酸钙材料。每种材料都通过标准化细菌培养试验进行了体外测试。抗菌活性是通过测量每种材料暴露于细菌培养物后周围的抑菌区来评估的:结果:材料 A 的抗菌活性最高,平均抑菌区为 12.3 毫米,其次是材料 C(9.8 毫米)、材料 D(8.5 毫米)和材料 B(6.2 毫米)。这些任意值反映了每种材料在抑制细菌生长方面的相对功效:我们的研究结果表明,在测试过的牙周植骨材料中,材料 A 的抗菌性能最强。这可能有助于降低术后感染的风险,从而改善牙周植骨手术的临床效果。为了阐明这些材料抗菌作用的机制,并在临床环境中验证我们的体外研究结果,我们有必要开展进一步的研究。
Comparative Analysis of the Antibacterial Properties of Various Periodontal Bone Graft Materials In Vitro.
Background: Periodontal bone grafting is a common procedure in dentistry to restore bone loss resulting from periodontal disease. Various graft materials are available, each with different antibacterial properties. Understanding these properties is crucial for successful grafting outcomes.
Materials and methods: In this study, we conducted a comparative analysis of the antibacterial properties of four commonly used periodontal bone graft materials: The graft used were A: Hydroxyapatite, B: B TCP, C: Bioactive glass, D: Calcium Phosphate materials. Each material was subjected to in vitro testing using a standardized bacterial culture assay. Antibacterial activity was assessed by measuring the zone of inhibition around each material after exposure to bacterial cultures.
Results: Material A exhibited the highest antibacterial activity with an average zone of inhibition of 12.3 mm, followed by Material C with 9.8 mm, Material D with 8.5 mm, and Material B with 6.2 mm. These arbitrary values reflect the relative efficacy of each material in inhibiting bacterial growth.
Conclusion: Our findings suggest that Material A possesses the strongest antibacterial properties among the tested periodontal bone graft materials. This may contribute to improved clinical outcomes in periodontal bone grafting procedures by reducing the risk of postoperative infections. Further research is warranted to elucidate the mechanisms underlying the antibacterial effects of these materials and to validate our in vitro findings in clinical settings.