Azharuddin Sajid Syed Khaja, Mohd Saleem, Mubashir Zafar, Soha Moursi, Ghorashy Eltayeb Yousif Mohammed, Syed Monowar Alam Shahid, Sahar Hammam, Safia Moussa, Mohammed Salem Alharbi, Ahmed Nawi Alshammari
{"title":"盆腔炎与卵巢癌、子宫癌、宫颈癌和阴道癌风险之间的关系--荟萃分析。","authors":"Azharuddin Sajid Syed Khaja, Mohd Saleem, Mubashir Zafar, Soha Moursi, Ghorashy Eltayeb Yousif Mohammed, Syed Monowar Alam Shahid, Sahar Hammam, Safia Moussa, Mohammed Salem Alharbi, Ahmed Nawi Alshammari","doi":"10.1007/s00404-024-07748-z","DOIUrl":null,"url":null,"abstract":"<div><h3>Background and aim</h3><p>The present meta-analysis aims to investigate a potential link between pelvic inflammatory disease (PID) and an increased risk of genitourinary cancers (ovarian, cervical, uterus, and vagina cancers). While previous research has hinted at a possible link, this meta-analysis seeks to delve deeper into the available evidence. Understanding this association is crucial for preventive strategies and improving clinical management practices.</p><h3>Methodology</h3><p>A comprehensive literature search was conducted across various databases, covering studies published between 2016 and 2024. We included 13 observational studies meeting stringent criteria, followed by meticulous data extraction and quality assessment. Meta-analytical techniques were then employed to calculate pooled odds ratios (ORs), adjusted hazard ratios (HRs), and 95% confidence intervals (CIs), with heterogeneity assessed using the I<sup>2</sup> statistic.</p><h3>Results</h3><p>Our analysis revealed significant findings, underscoring the association between PID and increased risks of genitourinary cancers. Specifically, individuals with a history of PID demonstrated notably higher odds of developing ovarian cancer (OR = 1.477, 95% CI 1.033–2.207), uterine cancer (OR = 1.263, 95% CI 0.827–2.143), cervical cancer (OR = 1.000, 95% CI 0.900–1.100), and vaginal cancer (OR = 2.500, 95% CI 1.400–4.000) compared to those without such a history. The overall heterogeneity across studies was high (<i>I</i><sup>2</sup> = 82.92%), suggesting varying trends across different populations and study designs.</p><h3>Conclusion</h3><p>This meta-analysis provides updated evidence supporting a significant association between PID and an increased risk of cervical, ovarian, and uterine cancers. Early detection and management of PID are crucial in potentially mitigating the risk of these cancers.</p></div>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":null,"pages":null},"PeriodicalIF":2.1000,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Association between pelvic inflammatory disease and risk of ovarian, uterine, cervical, and vaginal cancers—a meta-analysis\",\"authors\":\"Azharuddin Sajid Syed Khaja, Mohd Saleem, Mubashir Zafar, Soha Moursi, Ghorashy Eltayeb Yousif Mohammed, Syed Monowar Alam Shahid, Sahar Hammam, Safia Moussa, Mohammed Salem Alharbi, Ahmed Nawi Alshammari\",\"doi\":\"10.1007/s00404-024-07748-z\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background and aim</h3><p>The present meta-analysis aims to investigate a potential link between pelvic inflammatory disease (PID) and an increased risk of genitourinary cancers (ovarian, cervical, uterus, and vagina cancers). While previous research has hinted at a possible link, this meta-analysis seeks to delve deeper into the available evidence. Understanding this association is crucial for preventive strategies and improving clinical management practices.</p><h3>Methodology</h3><p>A comprehensive literature search was conducted across various databases, covering studies published between 2016 and 2024. We included 13 observational studies meeting stringent criteria, followed by meticulous data extraction and quality assessment. Meta-analytical techniques were then employed to calculate pooled odds ratios (ORs), adjusted hazard ratios (HRs), and 95% confidence intervals (CIs), with heterogeneity assessed using the I<sup>2</sup> statistic.</p><h3>Results</h3><p>Our analysis revealed significant findings, underscoring the association between PID and increased risks of genitourinary cancers. Specifically, individuals with a history of PID demonstrated notably higher odds of developing ovarian cancer (OR = 1.477, 95% CI 1.033–2.207), uterine cancer (OR = 1.263, 95% CI 0.827–2.143), cervical cancer (OR = 1.000, 95% CI 0.900–1.100), and vaginal cancer (OR = 2.500, 95% CI 1.400–4.000) compared to those without such a history. The overall heterogeneity across studies was high (<i>I</i><sup>2</sup> = 82.92%), suggesting varying trends across different populations and study designs.</p><h3>Conclusion</h3><p>This meta-analysis provides updated evidence supporting a significant association between PID and an increased risk of cervical, ovarian, and uterine cancers. Early detection and management of PID are crucial in potentially mitigating the risk of these cancers.</p></div>\",\"PeriodicalId\":8330,\"journal\":{\"name\":\"Archives of Gynecology and Obstetrics\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2024-09-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Archives of Gynecology and Obstetrics\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s00404-024-07748-z\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"OBSTETRICS & GYNECOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archives of Gynecology and Obstetrics","FirstCategoryId":"3","ListUrlMain":"https://link.springer.com/article/10.1007/s00404-024-07748-z","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
背景和目的:本荟萃分析旨在研究盆腔炎(PID)与泌尿生殖系统癌症(卵巢癌、宫颈癌、子宫癌和阴道癌)风险增加之间的潜在联系。虽然以往的研究已经暗示了两者之间可能存在的联系,但这项荟萃分析试图深入研究现有的证据。了解这种关联对于制定预防策略和改进临床管理实践至关重要:我们在各种数据库中进行了全面的文献检索,涵盖了 2016 年至 2024 年间发表的研究。我们纳入了 13 项符合严格标准的观察性研究,随后进行了细致的数据提取和质量评估。然后采用元分析技术计算汇总的几率比(ORs)、调整后的危险比(HRs)和95%置信区间(CIs),并使用I2统计量评估异质性:我们的分析结果表明,PID与泌尿生殖系统癌症风险增加之间存在重要关联。具体而言,与无PID病史者相比,有PID病史者患卵巢癌(OR = 1.477,95% CI 1.033-2.207)、子宫癌(OR = 1.263,95% CI 0.827-2.143)、宫颈癌(OR = 1.000,95% CI 0.900-1.100)和阴道癌(OR = 2.500,95% CI 1.400-4.000)的几率明显更高。各研究之间的总体异质性很高(I2 = 82.92%),表明不同人群和研究设计的趋势各不相同:这项荟萃分析提供了最新证据,证明PID与宫颈癌、卵巢癌和子宫癌风险增加之间存在显著关联。及早发现和治疗 PID 对降低罹患这些癌症的风险至关重要。
Association between pelvic inflammatory disease and risk of ovarian, uterine, cervical, and vaginal cancers—a meta-analysis
Background and aim
The present meta-analysis aims to investigate a potential link between pelvic inflammatory disease (PID) and an increased risk of genitourinary cancers (ovarian, cervical, uterus, and vagina cancers). While previous research has hinted at a possible link, this meta-analysis seeks to delve deeper into the available evidence. Understanding this association is crucial for preventive strategies and improving clinical management practices.
Methodology
A comprehensive literature search was conducted across various databases, covering studies published between 2016 and 2024. We included 13 observational studies meeting stringent criteria, followed by meticulous data extraction and quality assessment. Meta-analytical techniques were then employed to calculate pooled odds ratios (ORs), adjusted hazard ratios (HRs), and 95% confidence intervals (CIs), with heterogeneity assessed using the I2 statistic.
Results
Our analysis revealed significant findings, underscoring the association between PID and increased risks of genitourinary cancers. Specifically, individuals with a history of PID demonstrated notably higher odds of developing ovarian cancer (OR = 1.477, 95% CI 1.033–2.207), uterine cancer (OR = 1.263, 95% CI 0.827–2.143), cervical cancer (OR = 1.000, 95% CI 0.900–1.100), and vaginal cancer (OR = 2.500, 95% CI 1.400–4.000) compared to those without such a history. The overall heterogeneity across studies was high (I2 = 82.92%), suggesting varying trends across different populations and study designs.
Conclusion
This meta-analysis provides updated evidence supporting a significant association between PID and an increased risk of cervical, ovarian, and uterine cancers. Early detection and management of PID are crucial in potentially mitigating the risk of these cancers.
期刊介绍:
Founded in 1870 as "Archiv für Gynaekologie", Archives of Gynecology and Obstetrics has a long and outstanding tradition. Since 1922 the journal has been the Organ of the Deutsche Gesellschaft für Gynäkologie und Geburtshilfe. "The Archives of Gynecology and Obstetrics" is circulated in over 40 countries world wide and is indexed in "PubMed/Medline" and "Science Citation Index Expanded/Journal Citation Report".
The journal publishes invited and submitted reviews; peer-reviewed original articles about clinical topics and basic research as well as news and views and guidelines and position statements from all sub-specialties in gynecology and obstetrics.