间歇性禁食对女性生殖功能的影响:动物和人体研究综述

IF 4.6 3区 医学 Q1 NUTRITION & DIETETICS Current Nutrition Reports Pub Date : 2024-12-01 Epub Date: 2024-09-25 DOI:10.1007/s13668-024-00569-1
Lei Mao, Aixia Liu, Xiaohui Zhang
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引用次数: 0

摘要

回顾的目的:间歇性禁食已受到广泛关注,但对其对女性生殖健康的影响还缺乏全面的了解。本综述旨在通过研究各种间歇性禁食方案及其对女性生殖功能的影响和潜在机制来填补这一空白:在健康的非超重/肥胖或怀孕动物模型中,隔日禁食(ADF)和 8 小时限时进食(TRF)可能会对生殖功能产生不利影响。然而,这些方案显示出减轻高脂饮食(HFD)或环境暴露所引起的负面影响的潜力。在正常体重和高脂饮食动物模型中,10 小时 TRF 都能改善生育能力。对于超重/肥胖或多囊卵巢综合症(PCOS)妇女,5:2 饮食和 TRF 能显著降低游离雄激素指数,同时提高性激素结合球蛋白,有望改善月经调节。对于穆斯林孕妇而言,现有数据并未强烈显示斋月禁食对早产有不利影响,但需要考虑对产妇体重增加、新生儿出生体重和后代长期健康的潜在不利影响。将间歇性禁食与女性生殖健康联系起来的因素包括昼夜节律、肠道微生物群、代谢调节器和可改变的生活方式。在这一不断发展的领域中,得出明确的结论仍然具有挑战性。尽管如此,我们的研究结果强调了间歇性禁食疗法作为一种治疗方法,在解决肥胖和多囊卵巢综合症女性月经不调和不孕症方面的潜在作用。另一方面,孕妇应认识到间歇性禁食疗法的潜在风险。
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Effects of Intermittent Fasting on Female Reproductive Function: A Review of Animal and Human Studies.

Purpose of review: Intermittent fasting has gained significant attention, yet a comprehensive understanding of its impact on female reproductive health is lacking. This review aims to fill this gap by examining various intermittent fasting regimens and their effects on female reproductive function, along with potential mechanisms.

Recent findings: In healthy non-overweight/obese or pregnant animal models, alternate-day fasting (ADF) and an 8-h time-restricted feeding (TRF) window may have adverse effects on reproductive function. However, these regimens show potential to mitigate negative consequences induced by a high-fat diet (HFD) or environmental exposure. A 10-h TRF demonstrates benefits in improving fertility in both normal-weight and HFD-fed animal models. In women with overweight/obesity or polycystic ovary syndrome (PCOS), the 5:2 diet and TRF significantly reduce the free androgen index while elevating sex hormone binding globulin, promising improvements in menstrual regulation. For pregnant Muslim women, available data do not strongly indicate adverse effects of Ramadan fasting on preterm delivery, but potential downsides to maternal weight gain, neonatal birthweight, and long-term offspring health need consideration. Factors linking intermittent fasting to female reproductive health include the circadian clock, gut microbiota, metabolic regulators, and modifiable lifestyles. Drawing definitive conclusions remains challenging in this evolving area. Nonetheless, our findings underscore the potential utility of intermittent fasting regimens as a therapeutic approach for addressing menstruation irregularities and infertility in women with obesity and PCOS. On the other hand, pregnant women should remain cognizant of potential risks associated with intermittent fasting practices.

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来源期刊
Current Nutrition Reports
Current Nutrition Reports Agricultural and Biological Sciences-Food Science
CiteScore
7.70
自引率
2.00%
发文量
59
期刊介绍: This journal aims to provide comprehensive review articles that emphasize significant developments in nutrition research emerging in recent publications. By presenting clear, insightful, balanced contributions by international experts, the journal intends to discuss the influence of nutrition on major health conditions such as diabetes, cardiovascular disease, cancer, and obesity, as well as the impact of nutrition on genetics, metabolic function, and public health. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas across the field. Section Editors select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. We also provide commentaries from well-known figures in the field, and an Editorial Board of more than 25 internationally diverse members reviews the annual table of contents, suggests topics of special importance to their country/region, and ensures that topics and current and include emerging research.
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