{"title":"Guarea glomerulata Harms(瓜叶科)叶片中的抗疟特化化合物。","authors":"Gervais Mouthé Happi, Alain Tadjong Tcho, Klev Gaïtan Sikam, Guy-Paulin Mouthé Kemayou, Jacqueline Poffelie Kamegne, Dzouemo Liliane Clotilde, Jean Duplex Wansi","doi":"10.1080/14786419.2024.2407510","DOIUrl":null,"url":null,"abstract":"<p><p>To the best of our knowledge, this is the first chemical study of <i>Guarea glomerulata</i> that led to the isolation and characterisation of nine distinct compounds from its methanolic leaves extract including one new trinortriterpenoid glomerulatin along with eight known compounds amongst which five compounds namely azadirone, oleanolic acid, sericoside, cleomiscosin D and griffonin reported for the first time from the genus <i>Guarea</i>. All the isolated compounds have been evaluated <i>in vitro</i> for their antiplasmodial potency against the chloroquine-sensitive strain <i>P. falciparum</i> 3D7. The results showed that glomerulatin and azadirone were the most active compounds with IC<sub>50</sub> values of 1.02 ± 0.2 <i>μ</i>M and 1.48 ± 0.4 <i>μ</i>M, respectively. This study enriches the chemistry of the genus <i>Guarea</i> and further supports the identification of Meliaceae plants as a good source of antiplasmodial candidates for the development of new potent drugs against malaria.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9000,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Antiplasmodial specialised compounds from the leaves of <i>Guarea glomerulata</i> Harms (Meliaceae).\",\"authors\":\"Gervais Mouthé Happi, Alain Tadjong Tcho, Klev Gaïtan Sikam, Guy-Paulin Mouthé Kemayou, Jacqueline Poffelie Kamegne, Dzouemo Liliane Clotilde, Jean Duplex Wansi\",\"doi\":\"10.1080/14786419.2024.2407510\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>To the best of our knowledge, this is the first chemical study of <i>Guarea glomerulata</i> that led to the isolation and characterisation of nine distinct compounds from its methanolic leaves extract including one new trinortriterpenoid glomerulatin along with eight known compounds amongst which five compounds namely azadirone, oleanolic acid, sericoside, cleomiscosin D and griffonin reported for the first time from the genus <i>Guarea</i>. All the isolated compounds have been evaluated <i>in vitro</i> for their antiplasmodial potency against the chloroquine-sensitive strain <i>P. falciparum</i> 3D7. The results showed that glomerulatin and azadirone were the most active compounds with IC<sub>50</sub> values of 1.02 ± 0.2 <i>μ</i>M and 1.48 ± 0.4 <i>μ</i>M, respectively. This study enriches the chemistry of the genus <i>Guarea</i> and further supports the identification of Meliaceae plants as a good source of antiplasmodial candidates for the development of new potent drugs against malaria.</p>\",\"PeriodicalId\":18990,\"journal\":{\"name\":\"Natural Product Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2024-09-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Natural Product Research\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1080/14786419.2024.2407510\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Research","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1080/14786419.2024.2407510","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
Antiplasmodial specialised compounds from the leaves of Guarea glomerulata Harms (Meliaceae).
To the best of our knowledge, this is the first chemical study of Guarea glomerulata that led to the isolation and characterisation of nine distinct compounds from its methanolic leaves extract including one new trinortriterpenoid glomerulatin along with eight known compounds amongst which five compounds namely azadirone, oleanolic acid, sericoside, cleomiscosin D and griffonin reported for the first time from the genus Guarea. All the isolated compounds have been evaluated in vitro for their antiplasmodial potency against the chloroquine-sensitive strain P. falciparum 3D7. The results showed that glomerulatin and azadirone were the most active compounds with IC50 values of 1.02 ± 0.2 μM and 1.48 ± 0.4 μM, respectively. This study enriches the chemistry of the genus Guarea and further supports the identification of Meliaceae plants as a good source of antiplasmodial candidates for the development of new potent drugs against malaria.
期刊介绍:
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.