{"title":"海桐（DC.）对耐药金黄色葡萄球菌和志贺氏杆菌的抗氧化、抗菌和抗生物膜活性","authors":"Sajna Sameekshya Hota, Dibya Ranjan Sahoo, Subhaswaraj Pattnaik, Monika Mishra, Tapasa Mishra, Tanuja Sahu, Baishali Basundhara Naik, Malayamarutham Kalyankumarraju, Amit Kumar Dixit, Deepak Lamba, Sanjaya Kumar Y R, Rabinarayan Acharya, Pradeep Kumar Naik","doi":"10.1080/14786419.2024.2410422","DOIUrl":null,"url":null,"abstract":"<p><p>Gandhamardan has a rich heritage of floristic diversity with undocumented medicinal plants, called Anukta Dravya having immense pharmacological values. Among them, <i>Pittosporum napaulense</i> (DC.) Rehder & E. H. Wilson is an important medicinal plant with widespread pharmacological importance. The antioxidant potential, antibacterial and antibiofilm activities of <i>P. napaulense</i> (DC.) were evaluated. The ethanolic extract showed the highest share of phenolic and flavonoid contents responsible for DPPH and ABTS radical scavenging activity with an IC50 of 5.58 and 5.28 µg/ml, respectively. In addition, the extracts also showed antibacterial and antibiofilm properties against multidrug-resistant bacterial strains, <i>Staphylococcus aureus</i> and <i>Shigella</i> sp. The biological activities of <i>P. napaulense</i> (DC.) bark could be attributed to the presence of phytoconstituents such as Malabaricone C, Borapetoside B, Kanzonol R. as evident from UPLC-Q-TOF-MS analysis. Based on the bioactivities; this plant could be explored for the development of potential therapeutic drug candidates against severe bacterial diseases.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9000,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Antioxidant, antibacterial and antibiofilm activities of <i>Pittosporum napaulense</i> (DC.) against drug-resistant <i>Staphylococcus aureus</i> and <i>Shigella</i> sp.\",\"authors\":\"Sajna Sameekshya Hota, Dibya Ranjan Sahoo, Subhaswaraj Pattnaik, Monika Mishra, Tapasa Mishra, Tanuja Sahu, Baishali Basundhara Naik, Malayamarutham Kalyankumarraju, Amit Kumar Dixit, Deepak Lamba, Sanjaya Kumar Y R, Rabinarayan Acharya, Pradeep Kumar Naik\",\"doi\":\"10.1080/14786419.2024.2410422\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Gandhamardan has a rich heritage of floristic diversity with undocumented medicinal plants, called Anukta Dravya having immense pharmacological values. Among them, <i>Pittosporum napaulense</i> (DC.) Rehder & E. H. Wilson is an important medicinal plant with widespread pharmacological importance. The antioxidant potential, antibacterial and antibiofilm activities of <i>P. napaulense</i> (DC.) were evaluated. The ethanolic extract showed the highest share of phenolic and flavonoid contents responsible for DPPH and ABTS radical scavenging activity with an IC50 of 5.58 and 5.28 µg/ml, respectively. In addition, the extracts also showed antibacterial and antibiofilm properties against multidrug-resistant bacterial strains, <i>Staphylococcus aureus</i> and <i>Shigella</i> sp. The biological activities of <i>P. napaulense</i> (DC.) bark could be attributed to the presence of phytoconstituents such as Malabaricone C, Borapetoside B, Kanzonol R. as evident from UPLC-Q-TOF-MS analysis. Based on the bioactivities; this plant could be explored for the development of potential therapeutic drug candidates against severe bacterial diseases.</p>\",\"PeriodicalId\":18990,\"journal\":{\"name\":\"Natural Product Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2024-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Natural Product Research\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1080/14786419.2024.2410422\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Research","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1080/14786419.2024.2410422","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
摘要
甘达玛尔丹拥有丰富的植物多样性遗产，未记载的药用植物被称为 Anukta Dravya，具有巨大的药用价值。其中，Pittosporum napaulense (DC.) Rehder & E. H. Wilson 是一种重要的药用植物，具有广泛的药理作用。本研究评估了 Pittosporum napaulense (DC.) 的抗氧化潜力、抗菌和抗生物膜活性。乙醇提取物中的酚类和类黄酮含量最高，其 DPPH 和 ABTS 自由基清除活性的 IC50 分别为 5.58 和 5.28 µg/ml。从 UPLC-Q-TOF-MS 分析中可以看出，P. napaulense (DC.) 树皮的生物活性可归因于其中的植物成分，如 Malabaricone C、Borapetoside B 和 Kanzonol R。基于这些生物活性，这种植物可用于开发潜在的治疗药物，以对抗严重的细菌性疾病。
Antioxidant, antibacterial and antibiofilm activities of Pittosporum napaulense (DC.) against drug-resistant Staphylococcus aureus and Shigella sp.
Gandhamardan has a rich heritage of floristic diversity with undocumented medicinal plants, called Anukta Dravya having immense pharmacological values. Among them, Pittosporum napaulense (DC.) Rehder & E. H. Wilson is an important medicinal plant with widespread pharmacological importance. The antioxidant potential, antibacterial and antibiofilm activities of P. napaulense (DC.) were evaluated. The ethanolic extract showed the highest share of phenolic and flavonoid contents responsible for DPPH and ABTS radical scavenging activity with an IC50 of 5.58 and 5.28 µg/ml, respectively. In addition, the extracts also showed antibacterial and antibiofilm properties against multidrug-resistant bacterial strains, Staphylococcus aureus and Shigella sp. The biological activities of P. napaulense (DC.) bark could be attributed to the presence of phytoconstituents such as Malabaricone C, Borapetoside B, Kanzonol R. as evident from UPLC-Q-TOF-MS analysis. Based on the bioactivities; this plant could be explored for the development of potential therapeutic drug candidates against severe bacterial diseases.
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
