原发性脑肿瘤患者认知表型的神经解剖特征。

IF 3.7 Q1 CLINICAL NEUROLOGY Neuro-oncology advances Pub Date : 2024-08-29 eCollection Date: 2024-01-01 DOI:10.1093/noajnl/vdae152
Jiwandeep S Kohli, Anny Reyes, Austin Hopper, Alena Stasenko, Natalia Menendez, Kathryn R Tringale, Mia Salans, Roshan Karunamuni, Jona A Hattangadi-Gluth, Carrie R McDonald
{"title":"原发性脑肿瘤患者认知表型的神经解剖特征。","authors":"Jiwandeep S Kohli, Anny Reyes, Austin Hopper, Alena Stasenko, Natalia Menendez, Kathryn R Tringale, Mia Salans, Roshan Karunamuni, Jona A Hattangadi-Gluth, Carrie R McDonald","doi":"10.1093/noajnl/vdae152","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Patients with brain tumors demonstrate heterogeneous patterns of cognitive impairment, likely related to multifactorial etiologies and variable tumor-specific factors. Cognitive phenotyping offers a patient-centered approach to parsing heterogeneity by classifying individuals based on patterns of impairment. The aim of this study was to investigate the neuroanatomical patterns associated with each phenotype to gain a better understanding of the mechanisms underlying impairments.</p><p><strong>Methods: </strong>Patients with primary brain tumors were recruited for a prospective, observational study. Patients were cognitively phenotyped using latent profile analysis in a prior study, revealing 3 distinct groups: <i>generalized</i>, <i>isolated verbal memory</i>, and <i>minimal impairment</i>. Whole brain cortical thickness (CT), fractional anisotropy, and mean diffusivity (MD) were compared across phenotypes, and associations between imaging metrics and cognitive scores were explored.</p><p><strong>Results: </strong>Neurocognitive, structural MRI, and diffusion MRI data were available for 82 participants at baseline. Compared to the minimal impairment group, the generalized impairment group showed a widespread, bi-hemispheric pattern of decreased CT (<i>P</i>-value range: .004-.049), while the verbal memory impairment group showed decreased CT (<i>P</i>-value range: .006-.049) and increased MD (<i>P</i>-value range: .015-.045) bilaterally in the temporal lobes. In the verbal memory impairment group only, increased parahippocampal MD was associated with lower verbal memory scores (<i>P</i>-values < .01).</p><p><strong>Conclusions: </strong>Cognitive phenotypes in patients with brain tumors showed unique patterns of brain pathology, suggesting different underlying mechanisms of their impairment profiles. These distinct patterns highlight the biological relevance of our phenotyping approach and help to identify areas of structural and microstructural vulnerability that could inform treatment decisions.</p>","PeriodicalId":94157,"journal":{"name":"Neuro-oncology advances","volume":"6 1","pages":"vdae152"},"PeriodicalIF":3.7000,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11445899/pdf/","citationCount":"0","resultStr":"{\"title\":\"Neuroanatomical profiles of cognitive phenotypes in patients with primary brain tumors.\",\"authors\":\"Jiwandeep S Kohli, Anny Reyes, Austin Hopper, Alena Stasenko, Natalia Menendez, Kathryn R Tringale, Mia Salans, Roshan Karunamuni, Jona A Hattangadi-Gluth, Carrie R McDonald\",\"doi\":\"10.1093/noajnl/vdae152\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Patients with brain tumors demonstrate heterogeneous patterns of cognitive impairment, likely related to multifactorial etiologies and variable tumor-specific factors. Cognitive phenotyping offers a patient-centered approach to parsing heterogeneity by classifying individuals based on patterns of impairment. The aim of this study was to investigate the neuroanatomical patterns associated with each phenotype to gain a better understanding of the mechanisms underlying impairments.</p><p><strong>Methods: </strong>Patients with primary brain tumors were recruited for a prospective, observational study. Patients were cognitively phenotyped using latent profile analysis in a prior study, revealing 3 distinct groups: <i>generalized</i>, <i>isolated verbal memory</i>, and <i>minimal impairment</i>. Whole brain cortical thickness (CT), fractional anisotropy, and mean diffusivity (MD) were compared across phenotypes, and associations between imaging metrics and cognitive scores were explored.</p><p><strong>Results: </strong>Neurocognitive, structural MRI, and diffusion MRI data were available for 82 participants at baseline. Compared to the minimal impairment group, the generalized impairment group showed a widespread, bi-hemispheric pattern of decreased CT (<i>P</i>-value range: .004-.049), while the verbal memory impairment group showed decreased CT (<i>P</i>-value range: .006-.049) and increased MD (<i>P</i>-value range: .015-.045) bilaterally in the temporal lobes. In the verbal memory impairment group only, increased parahippocampal MD was associated with lower verbal memory scores (<i>P</i>-values < .01).</p><p><strong>Conclusions: </strong>Cognitive phenotypes in patients with brain tumors showed unique patterns of brain pathology, suggesting different underlying mechanisms of their impairment profiles. These distinct patterns highlight the biological relevance of our phenotyping approach and help to identify areas of structural and microstructural vulnerability that could inform treatment decisions.</p>\",\"PeriodicalId\":94157,\"journal\":{\"name\":\"Neuro-oncology advances\",\"volume\":\"6 1\",\"pages\":\"vdae152\"},\"PeriodicalIF\":3.7000,\"publicationDate\":\"2024-08-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11445899/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Neuro-oncology advances\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1093/noajnl/vdae152\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuro-oncology advances","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/noajnl/vdae152","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0

摘要

背景:脑肿瘤患者表现出不同的认知障碍模式,这可能与多因素病因和可变的肿瘤特异性因素有关。认知表型分析提供了一种以患者为中心的方法,通过根据损伤模式对个体进行分类来解析异质性。本研究的目的是调查与每种表型相关的神经解剖模式,以更好地了解损伤的内在机制:方法:招募原发性脑肿瘤患者进行前瞻性观察研究。在之前的一项研究中,利用潜伏特征分析对患者进行了认知表型分析,发现了3个不同的组别:泛化记忆、孤立言语记忆和轻微障碍。研究人员比较了不同表型的全脑皮质厚度(CT)、分数各向异性和平均扩散率(MD),并探讨了成像指标与认知评分之间的关联:82名参与者的神经认知、结构磁共振成像和弥散磁共振成像基线数据可用。与轻度损伤组相比,广泛性损伤组显示出广泛的双半球 CT 下降模式(P 值范围:.004-.049),而言语记忆损伤组则显示出双侧颞叶 CT 下降(P 值范围:.006-.049)和 MD 增加(P 值范围:.015-.045)。仅在言语记忆障碍组中,海马旁 MD 的增加与言语记忆得分的降低有关(P 值 结论):脑肿瘤患者的认知表型显示出独特的脑部病理模式,表明其损伤特征的潜在机制各不相同。这些独特的模式凸显了我们的表型分析方法的生物学相关性,并有助于确定结构和微结构的薄弱区域,为治疗决策提供依据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Neuroanatomical profiles of cognitive phenotypes in patients with primary brain tumors.

Background: Patients with brain tumors demonstrate heterogeneous patterns of cognitive impairment, likely related to multifactorial etiologies and variable tumor-specific factors. Cognitive phenotyping offers a patient-centered approach to parsing heterogeneity by classifying individuals based on patterns of impairment. The aim of this study was to investigate the neuroanatomical patterns associated with each phenotype to gain a better understanding of the mechanisms underlying impairments.

Methods: Patients with primary brain tumors were recruited for a prospective, observational study. Patients were cognitively phenotyped using latent profile analysis in a prior study, revealing 3 distinct groups: generalized, isolated verbal memory, and minimal impairment. Whole brain cortical thickness (CT), fractional anisotropy, and mean diffusivity (MD) were compared across phenotypes, and associations between imaging metrics and cognitive scores were explored.

Results: Neurocognitive, structural MRI, and diffusion MRI data were available for 82 participants at baseline. Compared to the minimal impairment group, the generalized impairment group showed a widespread, bi-hemispheric pattern of decreased CT (P-value range: .004-.049), while the verbal memory impairment group showed decreased CT (P-value range: .006-.049) and increased MD (P-value range: .015-.045) bilaterally in the temporal lobes. In the verbal memory impairment group only, increased parahippocampal MD was associated with lower verbal memory scores (P-values < .01).

Conclusions: Cognitive phenotypes in patients with brain tumors showed unique patterns of brain pathology, suggesting different underlying mechanisms of their impairment profiles. These distinct patterns highlight the biological relevance of our phenotyping approach and help to identify areas of structural and microstructural vulnerability that could inform treatment decisions.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
6.20
自引率
0.00%
发文量
0
审稿时长
12 weeks
期刊最新文献
The landscape of immune checkpoint inhibitor clinical trials in glioblastoma: A systematic review. miR-644a is a tumor cell-intrinsic mediator of sex bias in glioblastoma. International symposium on inheritable central nervous system (CNS) cancer predisposition: A prologue. Impact of antidepressant use on survival outcomes in glioma patients: A systematic review and meta-analysis. Non-small cell lung cancer with synchronous brain metastases: Identification of prognostic factors in a retrospective multicenter study (HOT 1701).
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1