介导细胞间通信温度控制的调节模块有助于树芽休眠的解除。

IF 9.4 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY EMBO Journal Pub Date : 2024-10-03 DOI:10.1038/s44318-024-00256-5
Shashank K Pandey, Jay Prakash Maurya, Bibek Aryal, Kamil Drynda, Aswin Nair, Pal Miskolczi, Rajesh Kumar Singh, Xiaobin Wang, Yujiao Ma, Tatiana de Souza Moraes, Emmanuelle M Bayer, Etienne Farcot, George W Bassel, Leah R Band, Rishikesh P Bhalerao
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引用次数: 0

摘要

通过质膜(PD)控制细胞间的通讯在植物发育过程中起着关键作用。在树芽中,低温条件(LT)会诱导质点从闭合状态转换为开放状态,从而恢复芽顶的细胞间通讯并解除休眠。利用遗传学和细胞生物学方法,我们确定了一种以前未曾描述过的转录因子--低温诱导 MADS-box 1(LIM1)--是一种由低温诱导的赤霉素(GA)途径的直接上游激活因子。LIM1-GA 模块通过负向调节胼胝质的积累来促进休眠的解除,从而介导低温诱导的质膜开放。LIM1 还能激活另一个低温诱导因子 FT1(FLOWERING LOCUS T)的表达,LIM1-FT1 形成了一个连贯的前馈回路,汇聚到休眠释放过程中赤霉素信号的低温调控上。数学建模和实验验证表明,赤霉素对 LIM1 的负反馈调控可能在维持花蕾对低温反应的稳健时间调控中发挥关键作用。这些结果揭示了将细胞-细胞通讯的温度控制与对树木适应至关重要的季节性生长调控联系起来的遗传因素。
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A regulatory module mediating temperature control of cell-cell communication facilitates tree bud dormancy release.

The control of cell-cell communication via plasmodesmata (PD) plays a key role in plant development. In tree buds, low-temperature conditions (LT) induce a switch in plasmodesmata from a closed to an open state, which restores cell-to-cell communication in the shoot apex and releases dormancy. Using genetic and cell-biological approaches, we have identified a previously uncharacterized transcription factor, Low-temperature-Induced MADS-box 1 (LIM1), as an LT-induced, direct upstream activator of the gibberellic acid (GA) pathway. The LIM1-GA module mediates low temperature-induced plasmodesmata opening, by negatively regulating callose accumulation to promote dormancy release. LIM1 also activates expression of FT1 (FLOWERING LOCUS T), another LT-induced factor, with LIM1-FT1 forming a coherent feedforward loop converging on low-temperature regulation of gibberellin signaling in dormancy release. Mathematical modeling and experimental validation suggest that negative feedback regulation of LIM1 by gibberellin could play a crucial role in maintaining the robust temporal regulation of bud responses to low temperature. These results reveal genetic factors linking temperature control of cell-cell communication with regulation of seasonally-aligned growth crucial for adaptation of trees.

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来源期刊
EMBO Journal
EMBO Journal 生物-生化与分子生物学
CiteScore
18.90
自引率
0.90%
发文量
246
审稿时长
1.5 months
期刊介绍: The EMBO Journal has stood as EMBO's flagship publication since its inception in 1982. Renowned for its international reputation in quality and originality, the journal spans all facets of molecular biology. It serves as a platform for papers elucidating original research of broad general interest in molecular and cell biology, with a distinct focus on molecular mechanisms and physiological relevance. With a commitment to promoting articles reporting novel findings of broad biological significance, The EMBO Journal stands as a key contributor to advancing the field of molecular biology.
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