Pincha Devage Sameera Madushan Fernando, Mei Jing Piao, Kyoung Ah Kang, Herath Mudiyanselage Udari Lakmini Herath, Eui Tae Kim, Chang Lim Hyun, Young Ree Kim, Jin Won Hyun
{"title":"丁素保护角质细胞免受微粒物质 2.5 和紫外线 B 造成的损伤","authors":"Pincha Devage Sameera Madushan Fernando, Mei Jing Piao, Kyoung Ah Kang, Herath Mudiyanselage Udari Lakmini Herath, Eui Tae Kim, Chang Lim Hyun, Young Ree Kim, Jin Won Hyun","doi":"10.1111/phpp.13001","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Butin is a naturally occurring compound with a wide range of medicinal properties, including anti-inflammatory, anti-arthritic, and antioxidant properties. Particulate matter 2.5 (PM<sub>2.5</sub>) and ultraviolet B (UVB) radiation contribute to skin cell damage via the induction of oxidative stress.</p><p><strong>Methods: </strong>This study sought to assess the protective effects of butin against damage triggered by PM<sub>2.5</sub> and UVB in human HaCaT keratinocytes. Assessments were performed to evaluate cell viability, apoptosis, and cellular component damage.</p><p><strong>Results: </strong>Butin exhibited its protective ability via the inhibition of PM<sub>2.5</sub>-induced reactive oxygen species generation, lipid peroxidation, DNA damage, protein carbonylation, and mitochondrial damage. Butin reduced the PM<sub>2.5</sub>-induced c-Fos and phospho-c-Jun protein levels as well as mitogen-activated protein kinase. Furthermore, butin mitigated PM<sub>2.5</sub>- and UVB-induced apoptosis.</p><p><strong>Conclusion: </strong>Butin had the potential as a pharmaceutical candidate for treating skin damage caused by PM<sub>2.5</sub> and UVB exposure.</p>","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":null,"pages":null},"PeriodicalIF":2.5000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Butin Protects Keratinocytes From Particulate Matter 2.5 and Ultraviolet B-Mediated Damages.\",\"authors\":\"Pincha Devage Sameera Madushan Fernando, Mei Jing Piao, Kyoung Ah Kang, Herath Mudiyanselage Udari Lakmini Herath, Eui Tae Kim, Chang Lim Hyun, Young Ree Kim, Jin Won Hyun\",\"doi\":\"10.1111/phpp.13001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Butin is a naturally occurring compound with a wide range of medicinal properties, including anti-inflammatory, anti-arthritic, and antioxidant properties. Particulate matter 2.5 (PM<sub>2.5</sub>) and ultraviolet B (UVB) radiation contribute to skin cell damage via the induction of oxidative stress.</p><p><strong>Methods: </strong>This study sought to assess the protective effects of butin against damage triggered by PM<sub>2.5</sub> and UVB in human HaCaT keratinocytes. Assessments were performed to evaluate cell viability, apoptosis, and cellular component damage.</p><p><strong>Results: </strong>Butin exhibited its protective ability via the inhibition of PM<sub>2.5</sub>-induced reactive oxygen species generation, lipid peroxidation, DNA damage, protein carbonylation, and mitochondrial damage. Butin reduced the PM<sub>2.5</sub>-induced c-Fos and phospho-c-Jun protein levels as well as mitogen-activated protein kinase. Furthermore, butin mitigated PM<sub>2.5</sub>- and UVB-induced apoptosis.</p><p><strong>Conclusion: </strong>Butin had the potential as a pharmaceutical candidate for treating skin damage caused by PM<sub>2.5</sub> and UVB exposure.</p>\",\"PeriodicalId\":20123,\"journal\":{\"name\":\"Photodermatology, photoimmunology & photomedicine\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2024-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Photodermatology, photoimmunology & photomedicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1111/phpp.13001\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"DERMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Photodermatology, photoimmunology & photomedicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/phpp.13001","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"DERMATOLOGY","Score":null,"Total":0}
Butin Protects Keratinocytes From Particulate Matter 2.5 and Ultraviolet B-Mediated Damages.
Background: Butin is a naturally occurring compound with a wide range of medicinal properties, including anti-inflammatory, anti-arthritic, and antioxidant properties. Particulate matter 2.5 (PM2.5) and ultraviolet B (UVB) radiation contribute to skin cell damage via the induction of oxidative stress.
Methods: This study sought to assess the protective effects of butin against damage triggered by PM2.5 and UVB in human HaCaT keratinocytes. Assessments were performed to evaluate cell viability, apoptosis, and cellular component damage.
Results: Butin exhibited its protective ability via the inhibition of PM2.5-induced reactive oxygen species generation, lipid peroxidation, DNA damage, protein carbonylation, and mitochondrial damage. Butin reduced the PM2.5-induced c-Fos and phospho-c-Jun protein levels as well as mitogen-activated protein kinase. Furthermore, butin mitigated PM2.5- and UVB-induced apoptosis.
Conclusion: Butin had the potential as a pharmaceutical candidate for treating skin damage caused by PM2.5 and UVB exposure.
期刊介绍：
The journal is a forum for new information about the direct and distant effects of electromagnetic radiation (ultraviolet, visible and infrared) mediated through skin. The divisions of the editorial board reflect areas of specific interest: aging, carcinogenesis, immunology, instrumentation and optics, lasers, photodynamic therapy, photosensitivity, pigmentation and therapy. Photodermatology, Photoimmunology & Photomedicine includes original articles, reviews, communications and editorials.
Original articles may include the investigation of experimental or pathological processes in humans or animals in vivo or the investigation of radiation effects in cells or tissues in vitro. Methodology need have no limitation; rather, it should be appropriate to the question addressed.
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