Polina A. Krokhicheva, Margarita A. Goldberg, Alexander S. Fomin, Dinara R. Khayrutdinova, Olga S. Antonova, Margarita A. Sadovnikova, Ivan V. Mikheev, Aleksander V. Leonov, Ekaterina M. Merzlyak, Daria A. Kovalishina, Suraya A. Akhmedova, Natalia S. Sergeeva, Marat R. Gafurov, Sergey M. Barinov, Vladimir S. Komlev
{"title":"用于无创可视化的掺钆可注射磷酸镁钙骨水泥","authors":"Polina A. Krokhicheva, Margarita A. Goldberg, Alexander S. Fomin, Dinara R. Khayrutdinova, Olga S. Antonova, Margarita A. Sadovnikova, Ivan V. Mikheev, Aleksander V. Leonov, Ekaterina M. Merzlyak, Daria A. Kovalishina, Suraya A. Akhmedova, Natalia S. Sergeeva, Marat R. Gafurov, Sergey M. Barinov, Vladimir S. Komlev","doi":"10.1016/j.jma.2024.09.002","DOIUrl":null,"url":null,"abstract":"Injectable bone cements are used in minimally invasive surgical techniques including vertebroplasty and kyphoplasty. This work is devoted to the development of magnesium-calcium phosphate cements (MCPCs) doped with gadolinium ions (Gd<sup>3+</sup>) for bone defect repair. Interaction between cement powders and a cement liquid resulted in the formation of newberyite and brushite phases, which gave mechanical strength up to 17 MPa without a thermal effect. The introduction of Gd<sup>3+</sup> into the lattice was confirmed by electron paramagnetic resonance spectroscopy; the doping increased injectivity while giving rise to antibacterial properties against <em>Escherichia coli</em>. Assays of the cement samples soaking in Kokubo's simulated body fluid revealed the formation of calcium phosphate coatings on the cements’ surface. The cements manifested biocompatibility with the MG-63 cell line and significantly enhanced contrast when Gd-MCPC was placed into a bone defect and examined by X-ray micro–computed tomography. For the first time, visualization of a Gd-doped cement material was achieved in a model of a bone defect analyzed by MRI.","PeriodicalId":16214,"journal":{"name":"Journal of Magnesium and Alloys","volume":null,"pages":null},"PeriodicalIF":15.8000,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Gadolinium-doped injectable magnesium-calcium phosphate bone cements for noninvasive visualization\",\"authors\":\"Polina A. Krokhicheva, Margarita A. Goldberg, Alexander S. Fomin, Dinara R. Khayrutdinova, Olga S. Antonova, Margarita A. Sadovnikova, Ivan V. Mikheev, Aleksander V. Leonov, Ekaterina M. Merzlyak, Daria A. Kovalishina, Suraya A. Akhmedova, Natalia S. Sergeeva, Marat R. Gafurov, Sergey M. Barinov, Vladimir S. Komlev\",\"doi\":\"10.1016/j.jma.2024.09.002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Injectable bone cements are used in minimally invasive surgical techniques including vertebroplasty and kyphoplasty. This work is devoted to the development of magnesium-calcium phosphate cements (MCPCs) doped with gadolinium ions (Gd<sup>3+</sup>) for bone defect repair. Interaction between cement powders and a cement liquid resulted in the formation of newberyite and brushite phases, which gave mechanical strength up to 17 MPa without a thermal effect. The introduction of Gd<sup>3+</sup> into the lattice was confirmed by electron paramagnetic resonance spectroscopy; the doping increased injectivity while giving rise to antibacterial properties against <em>Escherichia coli</em>. Assays of the cement samples soaking in Kokubo's simulated body fluid revealed the formation of calcium phosphate coatings on the cements’ surface. The cements manifested biocompatibility with the MG-63 cell line and significantly enhanced contrast when Gd-MCPC was placed into a bone defect and examined by X-ray micro–computed tomography. For the first time, visualization of a Gd-doped cement material was achieved in a model of a bone defect analyzed by MRI.\",\"PeriodicalId\":16214,\"journal\":{\"name\":\"Journal of Magnesium and Alloys\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":15.8000,\"publicationDate\":\"2024-10-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Magnesium and Alloys\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://doi.org/10.1016/j.jma.2024.09.002\",\"RegionNum\":1,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"METALLURGY & METALLURGICAL ENGINEERING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Magnesium and Alloys","FirstCategoryId":"88","ListUrlMain":"https://doi.org/10.1016/j.jma.2024.09.002","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"METALLURGY & METALLURGICAL ENGINEERING","Score":null,"Total":0}
Gadolinium-doped injectable magnesium-calcium phosphate bone cements for noninvasive visualization
Injectable bone cements are used in minimally invasive surgical techniques including vertebroplasty and kyphoplasty. This work is devoted to the development of magnesium-calcium phosphate cements (MCPCs) doped with gadolinium ions (Gd3+) for bone defect repair. Interaction between cement powders and a cement liquid resulted in the formation of newberyite and brushite phases, which gave mechanical strength up to 17 MPa without a thermal effect. The introduction of Gd3+ into the lattice was confirmed by electron paramagnetic resonance spectroscopy; the doping increased injectivity while giving rise to antibacterial properties against Escherichia coli. Assays of the cement samples soaking in Kokubo's simulated body fluid revealed the formation of calcium phosphate coatings on the cements’ surface. The cements manifested biocompatibility with the MG-63 cell line and significantly enhanced contrast when Gd-MCPC was placed into a bone defect and examined by X-ray micro–computed tomography. For the first time, visualization of a Gd-doped cement material was achieved in a model of a bone defect analyzed by MRI.
期刊介绍:
The Journal of Magnesium and Alloys serves as a global platform for both theoretical and experimental studies in magnesium science and engineering. It welcomes submissions investigating various scientific and engineering factors impacting the metallurgy, processing, microstructure, properties, and applications of magnesium and alloys. The journal covers all aspects of magnesium and alloy research, including raw materials, alloy casting, extrusion and deformation, corrosion and surface treatment, joining and machining, simulation and modeling, microstructure evolution and mechanical properties, new alloy development, magnesium-based composites, bio-materials and energy materials, applications, and recycling.