SRSF1 对维持骨骼肌生长和再生过程中卫星细胞的稳态至关重要

IF 8.9 1区医学 Journal of Cachexia, Sarcopenia and Muscle Pub Date : 2024-10-09 DOI:10.1002/jcsm.13607

Zhenzhen Wang, Qian Peng, Zhige Zhang, Xue You, Huimin Duan, Rula Sha, Ningyang Yuan, Zhigang Li, Zhiqin Xie, Jun Han, Ying Feng

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引用次数: 0

摘要

剪接因子 SRSF1 是细胞增殖的重要调节因子，在增殖活跃的卫星细胞（SC）中高表达。在通过 MyoD-Cre 产生的 SRSF1 基因敲除小鼠（KO）中，可以观察到出生后肌肉生长过程中的早期死亡和肌肉萎缩。尽管有这些发现，但SRSF1缺失影响卫星细胞功能的确切机制及其在肌肉再生中的作用仍有待阐明。

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SRSF1 Is Crucial for Maintaining Satellite Cell Homeostasis During Skeletal Muscle Growth and Regeneration

The splicing factor SRSF1 emerges as a mater regulator of cell proliferation, displaying high expression in actively proliferative satellite cells (SCs). In SRSF1 knockout mice (KO) generated via MyoD-Cre, early mortality and muscle atrophy are observed during postnatal muscle growth. Despite these findings, the precise mechanisms through which SRSF1 loss influences SCs' functions and its role in muscle regeneration remain to be elucidated.

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来源期刊

Journal of Cachexia, Sarcopenia and Muscle Medicine-Orthopedics and Sports Medicine

自引率

12.40%

发文量

期刊介绍： The Journal of Cachexia, Sarcopenia, and Muscle is a prestigious, peer-reviewed international publication committed to disseminating research and clinical insights pertaining to cachexia, sarcopenia, body composition, and the physiological and pathophysiological alterations occurring throughout the lifespan and in various illnesses across the spectrum of life sciences. This journal serves as a valuable resource for physicians, biochemists, biologists, dieticians, pharmacologists, and students alike.