红毛丹（Nephelium lappaceum L.）果皮多酚通过调节肠道微生物群和代谢物对 2 型糖尿病小鼠的降血糖作用

IF 4.5 2区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Molecular Nutrition & Food Research Pub Date : 2024-10-10 DOI:10.1002/mnfr.202400555

Qiuming Liu, Qingyu Ma, Jiao Li, Liping Sun, Yongliang Zhuang

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引用次数: 0

摘要

范围：2 型糖尿病（T2DM）是一种代谢性疾病，对全球公共卫生造成重大影响。据报道，红毛丹果皮多酚（RPPs）具有降血糖活性。然而，从肠道微生物群及其代谢物的角度进行的研究却很少：方法和结果：采用高脂饮食和链脲佐菌素建立的 T2DM 小鼠模型通过灌胃给药 RPPs。研究发现，RPPs 可通过改善糖脂代谢和肝功能来缓解高血糖症状。免疫组化表明，RPPs的降血糖作用受IRS-1/PI3K/AKT/GSK3β信号通路调控。RPPs 治疗重塑了肠道微生物群（Odoribacter、Lachnospiraceae_NK4A136_group、Lactobacillus、Toricibacter、Erysipelatoclostridium 和 Tuzzerella）的结构，并丰富了代谢产物（RPPs 衍生的尿石素、短链脂肪酸、脱氢胆酸、(+)-儿茶素、二氢小檗碱、紫檀芪和青蒿琥酯）。RPPs在改善糖脂代谢紊乱方面的作用与不同的肠道微生物群和代谢物有关：结论：肠道微生物群及其代谢物是 RPPs 降血糖作用的关键靶点。

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Hypoglycemic Effect of Rambutan (Nephelium lappaceum L.) Peel Polyphenols on Type 2 Diabetes Mice by Modulating Gut Microbiota and Metabolites.

Scope: Type 2 diabetes mellitus (T2DM) is a metabolic disease with a major global public health effect. Rambutan peel polyphenols (RPPs) have been reported to exert hypoglycemic activity. However, few studies have been explored from the viewpoint of gut microbiota and its metabolites.

Methods and results: RPPs are administered by gavage to a mice model of T2DM established by using a high-fat diet combined with streptozotocin. It finds that RPPs treatment alleviates hyperglycemia symptoms by improving glucolipid metabolism and liver function. Immunohistochemistry indicates that the antihyperglycemic effect of RPPs is regulated by the IRS-1/PI3K/AKT/GSK3β signaling pathway. RPPs treatment remodels the structure of gut microbiota (Odoribacter, Lachnospiraceae_NK4A136_group, Lactobacillus, Turicibacter, Erysipelatoclostridium, and Tuzzerella) and enriches the metabolites (RPPs-derived urolithins, short-chain fatty acids, dehydrocholic acid, (+)-catechin, dihydroberberine, pterostilbene, and artesunate) associated with diabetes regulation in T2DM mice. The effects of RPPs in ameliorating glycolipid metabolism disorders are correlated with differential gut microbiota and metabolites.

Conclusion: The gut microbiota and its metabolites are key targets for the hypoglycemic effects of RPPs.

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来源期刊

Molecular Nutrition & Food Research 工程技术-食品科技

CiteScore

8.70

自引率

1.90%

发文量

250

审稿时长

1.7 months

期刊介绍： Molecular Nutrition & Food Research is a primary research journal devoted to health, safety and all aspects of molecular nutrition such as nutritional biochemistry, nutrigenomics and metabolomics aiming to link the information arising from related disciplines: Bioactivity: Nutritional and medical effects of food constituents including bioavailability and kinetics. Immunology: Understanding the interactions of food and the immune system. Microbiology: Food spoilage, food pathogens, chemical and physical approaches of fermented foods and novel microbial processes. Chemistry: Isolation and analysis of bioactive food ingredients while considering environmental aspects.