土拉霉素、加美霉素和土霉素对牛的免疫调节作用

IF 2.3 2区 农林科学 Q1 VETERINARY SCIENCES BMC Veterinary Research Pub Date : 2024-10-09 DOI:10.1186/s12917-024-04254-x
W Wheat, L Chow, K Still-Brooks, R Moore-Foster, J Herman, R Hunter, F Garry, S Dow
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引用次数: 0

摘要

众所周知,某些抗生素(包括四环素类和大环内酯类)在其他物种中具有免疫抑制作用,但这些抗生素的免疫调节作用以前从未在牛身上进行过研究。为了解决这个问题,我们利用体外试验研究了土霉素、加红霉素和妥拉霉素对 T 细胞和巨噬细胞活化反应的影响。此外,我们还评估了这些抗生素对体内 T 细胞反应的影响,即用目前推荐剂量的这三种抗生素分别治疗健康牛。我们发现,在相关治疗药物浓度下,这三种抗生素都能明显抑制体外 T 细胞的增殖,并显著抑制巨噬细胞对 LPS 的活化反应。在单剂量使用每种抗生素治疗的牛中,我们观察到 T 细胞增殖和细胞因子的产生早在用药后 6 小时就开始受到显著抑制,48 小时后免疫抑制作用逐渐增强。在对高风险奶牛或肉牛使用抗生素进行预防性或变态反应性治疗时,应考虑这些脱靶效应(192 字)。
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Immune modulatory effects of tulathromycin, gamithromycin, and oxytetracycline in cattle.

Certain classes of antibiotics, including tetracyclines and macrolides, are known to exert immune suppressive effects in other species but the immune modulatory effects of these antibiotics have not been previously studied in cattle. To address this question, we investigated the effects of oxytetracycline, gamithromycin, and tulathromycin on T cell and macrophage responses to activation, using in vitro assays. In addition, we assessed the impact of these antibiotics on T cell responses in vivo following treatment of healthy cattle with currently recommended doses of each of the three antibiotics. We found that all 3 antibiotics markedly suppressed T cell proliferation in vitro at relevant therapeutic drug concentrations and significantly suppressed macrophage activation responses to LPS. In cattle treated with a single dose of each antibiotic, we observed significant suppression of T cell proliferation and cytokine production beginning as early as 6 h after administration, with increasing immune suppression observed at 48 h. Taken together, these results indicate that commonly used antibiotics in cattle exert significant immune modulatory activity, in addition to their antimicrobial activity. These off-target effects should be considered when using antibiotics for prophylaxis or metaphylaxis in high-risk dairy or beef cattle (192 words).

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来源期刊
BMC Veterinary Research
BMC Veterinary Research VETERINARY SCIENCES-
CiteScore
4.80
自引率
3.80%
发文量
420
审稿时长
3-6 weeks
期刊介绍: BMC Veterinary Research is an open access, peer-reviewed journal that considers articles on all aspects of veterinary science and medicine, including the epidemiology, diagnosis, prevention and treatment of medical conditions of domestic, companion, farm and wild animals, as well as the biomedical processes that underlie their health.
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