决定实验动物命运的决策树。

IF 1.3 4区 农林科学 Q2 VETERINARY SCIENCES Laboratory Animals Pub Date : 2024-10-08 DOI:10.1177/00236772241271034
Myhailo Reshetnykov, Karen Stumm, Michael Zwick, Jan Baumgart
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引用次数: 0

摘要

从事实验动物研究的机构经常面临伦理挑战,例如:我该如何处理不再适合用于实验目的的动物?这个问题的常见答案之一就是杀死它们。虽然杀死实验动物有许多科学上合理的理由,但我们决不能忽视我们对这些有生命的生物所承担的伦理责任。动物设施管理者和科学家经常发现自己处于道德两难境地,既要推进自己的研究,又要解决研究中所需实验动物的福利问题。我们提出了一个概念,其中包括六个决策树和建议,以便在考虑法律和道德因素的情况下,就是否需要在研究机构中杀死实验动物做出明智的决定。该概念基于德国的监管视角。不过,所有实验动物机构都可以实施动物福利措施和决策。这些建议提出了几种行动方案,包括实施一致的繁殖计划、探索替代用途、重新分配多余的动物及其器官,以及制定适当的饲养量限制,以确保提供适合物种的护理。我们鼓励科学家和动物设施管理者制定并实施适合其具体设施的决策框架和程序,希望这项工作能促进以深思熟虑和负责任的方式应对与实验动物杀戮相关的复杂挑战,推动科学进步和对这些动物的人道待遇。
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Decision trees for determining the fate of laboratory animals.

Facilities involved in laboratory animal research often face ethical challenges such as: what should I do with the animals that are no longer suitable for experimental purposes? One of the common answers to this question is to kill them. And while numerous scientifically justifiable reasons exist for killing laboratory animals, we must not overlook our ethical responsibility towards these sentient beings. Animal facility managers and scientists frequently find themselves in a moral dilemma, torn between furthering their research and addressing the well-being of experimental animals required for their studies. We elaborated a concept consisting of six decision trees and recommendations for making informed decisions about the need to kill laboratory animals in research facilities, considering legal and ethical considerations. The concept is based on the German regulatory perspective. However, the measures and decisions for animal welfare can be implemented in all laboratory animal facilities. These recommendations suggest several courses of action, including implementing consistent breeding plans, exploring alternative uses, reassigning surplus animals and their organs, and establishing appropriate housing capacity limits that ensure species-appropriate care. We encourage scientists and animal facility managers to develop and implement decision-making frameworks and procedures tailored to their specific facilities, in the hope that this work will promote a thoughtful and responsible approach to the complex challenges associated with the killing of laboratory animals, advancing scientific progress and the humane treatment of these animals.

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来源期刊
Laboratory Animals
Laboratory Animals 生物-动物学
CiteScore
4.90
自引率
8.30%
发文量
64
审稿时长
6-12 weeks
期刊介绍: The international journal of laboratory animal science and welfare, Laboratory Animals publishes peer-reviewed original papers and reviews on all aspects of the use of animals in biomedical research. The journal promotes improvements in the welfare or well-being of the animals used, it particularly focuses on research that reduces the number of animals used or which replaces animal models with in vitro alternatives.
期刊最新文献
An innovative approach for health and safety training and occupational health program annual enrollment for laboratory animal care and use personnel. Extended oxygen supplementation after thoracotomy in rats may improve welfare. Animal researchers' views on the publication of negative results and subsequent policy adoptions. Spontaneous hepatocellular and gastric tumours in African clawed frogs (Xenopus laevis). Single nucleotide polymorphism (SNP) characterisation of mouse inbred strains bred at MRC-National Institute for Medical Research.
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