体重指数与心血管疾病风险的蛋白质组特征。

IF 7.1 2区 医学 Q1 MEDICAL LABORATORY TECHNOLOGY Clinical chemistry Pub Date : 2024-10-11 DOI:10.1093/clinchem/hvae149
Hao Ma, Xuan Wang, Yoriko Heianza, JoAnn E Manson, Lu Qi
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引用次数: 0

摘要

背景:仅以体重指数(BMI)定义的肥胖症是一种代谢异质性疾病,不同个体的心血管表现各不相同。本研究旨在调查 BMI 蛋白质组特征与心血管疾病(CVD)主要亚型风险的关联:方法:英国生物库中共有 40 089 名基线时未患心血管疾病的参与者,他们的蛋白质组数据均由 Olink 检测法测定。根据与 BMI 相关的 67 种预先确定的血浆蛋白计算出 BMI 蛋白组评分(pro-BMI 评分):结果:pro-BMI 评分越高,患缺血性心脏病(IHD)和心力衰竭(HF)的风险越高,但与中风风险无关。比较最高四分位数和最低四分位数,IHD 的调整后危险比 (HR) 为 1.49(95% CI,1.32-1.67)(P-趋势 < 0.001),HF 的调整后危险比为 1.52(95% CI,1.25-1.85)(P-趋势 < 0.001)。进一步分析表明,pro-BMI 评分与心房颤动风险的关系主要受实际体重指数的影响,而 pro-BMI 评分与心房颤动风险的关系与实际体重指数和腰臀比(WHR)无关。正常体重指数组的pro-BMI评分与IHD风险之间的关联似乎比其他体重指数组更强(P-interaction = 0.004),正常WHR组的pro-BMI评分与IHD风险之间的关联比高WHR组更强(P-interaction = 0.049):结论:较高的 pro-BMI 评分与较高的 IHD 风险显著相关,与实际的 BMI 水平无关。我们的研究结果表明,血浆蛋白有望成为诊断肥胖的补充标记物,并可促进个性化干预。
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Proteomic Signature of BMI and Risk of Cardiovascular Disease.

Background: Obesity, defined by body mass index (BMI) alone, is a metabolically heterogeneous disorder with distinct cardiovascular manifestations across individuals. This study aimed to investigate the associations of a proteomic signature of BMI with risk of major subtypes of cardiovascular disease (CVD).

Methods: A total of 40 089 participants from UK Biobank, free of CVD at baseline, had complete data on proteomic data measured by the Olink assay. A BMI-proteomic score (pro-BMI score) was calculated from 67 pre-identified plasma proteins associated with BMI.

Results: A higher pro-BMI score was significantly associated with higher risks of ischemic heart disease (IHD) and heart failure (HF), but not with risk of stroke. Comparing the highest with the lowest quartiles, the adjusted hazard ratio (HR) for IHD was 1.49 (95% CI, 1.32-1.67) (P-trend < 0.001), and the adjusted HR for HF was 1.52 (95% CI, 1.25-1.85) (P-trend < 0.001). Further analyses showed that the association of pro-BMI score with HF risk was largely driven by the actual BMI, whereas the association of the pro-BMI score with IHD risk was independent of actual BMI and waist-to-hip ratio (WHR). The association between pro-BMI score and IHD risk appeared to be stronger in the normal BMI group than other BMI groups (P-interaction = 0.004) and stronger in the normal WHR group than the high WHR group (P-interaction = 0.049).

Conclusions: Higher pro-BMI score is significantly associated with higher IHD risk, independent of actual BMI levels. Our findings suggest that plasma proteins hold promise as complementary markers for diagnosing obesity and may facilitate personalized interventions.

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来源期刊
Clinical chemistry
Clinical chemistry 医学-医学实验技术
CiteScore
11.30
自引率
4.30%
发文量
212
审稿时长
1.7 months
期刊介绍: Clinical Chemistry is a peer-reviewed scientific journal that is the premier publication for the science and practice of clinical laboratory medicine. It was established in 1955 and is associated with the Association for Diagnostics & Laboratory Medicine (ADLM). The journal focuses on laboratory diagnosis and management of patients, and has expanded to include other clinical laboratory disciplines such as genomics, hematology, microbiology, and toxicology. It also publishes articles relevant to clinical specialties including cardiology, endocrinology, gastroenterology, genetics, immunology, infectious diseases, maternal-fetal medicine, neurology, nutrition, oncology, and pediatrics. In addition to original research, editorials, and reviews, Clinical Chemistry features recurring sections such as clinical case studies, perspectives, podcasts, and Q&A articles. It has the highest impact factor among journals of clinical chemistry, laboratory medicine, pathology, analytical chemistry, transfusion medicine, and clinical microbiology. The journal is indexed in databases such as MEDLINE and Web of Science.
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