Tiantian Hao , Ya Gao , Enhao Zheng , Huagong Yang , Yitong Pan , Peikai Zhang , Jing Xu , Zhaosheng Hou
{"title":"基于动态苯酚-聚氨酯和二硫键的多功能聚醚-聚氨酯弹性体:同时具有卓越的韧性、自愈性、形状记忆、抗菌和抗氧化性能","authors":"Tiantian Hao , Ya Gao , Enhao Zheng , Huagong Yang , Yitong Pan , Peikai Zhang , Jing Xu , Zhaosheng Hou","doi":"10.1016/j.eurpolymj.2024.113494","DOIUrl":null,"url":null,"abstract":"<div><div>Multifunctional polymers are highly desirable for developing smart materials in medical applications. This study proposed a facile strategy to fabricate a new multifunctional poly(ether‐urethane) incorporating disulfide bonds and phenol-urethane bonds (PEU−TS). The distinctive feature of the designed PEU−TS elastomers was the presence of abundant phenolic hydroxyl groups, dynamic aromatic disulfide bonds, phenol-urethane bonds, and multiple H-bonds between urethane groups and tannic acid (TA) molecules, which endowed the materials with superior antibacterial and antioxidative activities, self‐healing capabilities, and shape memory functions. Furthermore, the phenol-carbamate crosslinked networks enhanced the tensile properties and improved the biostability of the elastomers. Biocompatibility evaluation further demonstrated that networked PEU−TS composites possessed favorable cell viability and high cytocompatibility. The multifunctional PEU−TS elastomers with robust tensile properties hold great potential for application in durable implants and chronic wound dressings. This elaborate design could inspire the development of multifunctional PU materials over wide medical applications.</div></div>","PeriodicalId":315,"journal":{"name":"European Polymer Journal","volume":"220 ","pages":"Article 113494"},"PeriodicalIF":5.8000,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Multifunctional poly(ether‐urethane) elastomer based on dynamic phenol-urethane and disulfide bonds: Simultaneously showing superior toughness, self-healing, shape memory, antibacterial, and antioxidative properties\",\"authors\":\"Tiantian Hao , Ya Gao , Enhao Zheng , Huagong Yang , Yitong Pan , Peikai Zhang , Jing Xu , Zhaosheng Hou\",\"doi\":\"10.1016/j.eurpolymj.2024.113494\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Multifunctional polymers are highly desirable for developing smart materials in medical applications. This study proposed a facile strategy to fabricate a new multifunctional poly(ether‐urethane) incorporating disulfide bonds and phenol-urethane bonds (PEU−TS). The distinctive feature of the designed PEU−TS elastomers was the presence of abundant phenolic hydroxyl groups, dynamic aromatic disulfide bonds, phenol-urethane bonds, and multiple H-bonds between urethane groups and tannic acid (TA) molecules, which endowed the materials with superior antibacterial and antioxidative activities, self‐healing capabilities, and shape memory functions. Furthermore, the phenol-carbamate crosslinked networks enhanced the tensile properties and improved the biostability of the elastomers. Biocompatibility evaluation further demonstrated that networked PEU−TS composites possessed favorable cell viability and high cytocompatibility. The multifunctional PEU−TS elastomers with robust tensile properties hold great potential for application in durable implants and chronic wound dressings. This elaborate design could inspire the development of multifunctional PU materials over wide medical applications.</div></div>\",\"PeriodicalId\":315,\"journal\":{\"name\":\"European Polymer Journal\",\"volume\":\"220 \",\"pages\":\"Article 113494\"},\"PeriodicalIF\":5.8000,\"publicationDate\":\"2024-10-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Polymer Journal\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0014305724007559\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"POLYMER SCIENCE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Polymer Journal","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0014305724007559","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"POLYMER SCIENCE","Score":null,"Total":0}
引用次数: 0
摘要
多功能聚合物是开发医疗应用智能材料的理想材料。本研究提出了一种简单易行的策略,用于制造含有二硫键和苯酚-聚氨酯键的新型多功能聚醚-聚氨酯(PEU-TS)。所设计的 PEU-TS 弹性体的显著特点是含有丰富的酚羟基、动态芳香族二硫键、苯酚-氨基甲酸酯键,以及氨基甲酸酯基团与单宁酸(TA)分子之间的多个 H 键,从而使材料具有优异的抗菌和抗氧化活性、自愈合能力和形状记忆功能。此外,苯酚-氨基甲酸酯交联网络还增强了弹性体的拉伸性能,提高了其生物稳定性。生物相容性评估进一步表明,网络化 PEU-TS 复合材料具有良好的细胞活力和高细胞相容性。具有强大拉伸性能的多功能 PEU-TS 弹性体在耐用植入物和慢性伤口敷料方面具有巨大的应用潜力。这一精心设计可为多功能聚氨酯材料在广泛医疗应用领域的开发提供灵感。
Multifunctional poly(ether‐urethane) elastomer based on dynamic phenol-urethane and disulfide bonds: Simultaneously showing superior toughness, self-healing, shape memory, antibacterial, and antioxidative properties
Multifunctional polymers are highly desirable for developing smart materials in medical applications. This study proposed a facile strategy to fabricate a new multifunctional poly(ether‐urethane) incorporating disulfide bonds and phenol-urethane bonds (PEU−TS). The distinctive feature of the designed PEU−TS elastomers was the presence of abundant phenolic hydroxyl groups, dynamic aromatic disulfide bonds, phenol-urethane bonds, and multiple H-bonds between urethane groups and tannic acid (TA) molecules, which endowed the materials with superior antibacterial and antioxidative activities, self‐healing capabilities, and shape memory functions. Furthermore, the phenol-carbamate crosslinked networks enhanced the tensile properties and improved the biostability of the elastomers. Biocompatibility evaluation further demonstrated that networked PEU−TS composites possessed favorable cell viability and high cytocompatibility. The multifunctional PEU−TS elastomers with robust tensile properties hold great potential for application in durable implants and chronic wound dressings. This elaborate design could inspire the development of multifunctional PU materials over wide medical applications.
期刊介绍:
European Polymer Journal is dedicated to publishing work on fundamental and applied polymer chemistry and macromolecular materials. The journal covers all aspects of polymer synthesis, including polymerization mechanisms and chemical functional transformations, with a focus on novel polymers and the relationships between molecular structure and polymer properties. In addition, we welcome submissions on bio-based or renewable polymers, stimuli-responsive systems and polymer bio-hybrids. European Polymer Journal also publishes research on the biomedical application of polymers, including drug delivery and regenerative medicine. The main scope is covered but not limited to the following core research areas:
Polymer synthesis and functionalization
• Novel synthetic routes for polymerization, functional modification, controlled/living polymerization and precision polymers.
Stimuli-responsive polymers
• Including shape memory and self-healing polymers.
Supramolecular polymers and self-assembly
• Molecular recognition and higher order polymer structures.
Renewable and sustainable polymers
• Bio-based, biodegradable and anti-microbial polymers and polymeric bio-nanocomposites.
Polymers at interfaces and surfaces
• Chemistry and engineering of surfaces with biological relevance, including patterning, antifouling polymers and polymers for membrane applications.
Biomedical applications and nanomedicine
• Polymers for regenerative medicine, drug delivery molecular release and gene therapy
The scope of European Polymer Journal no longer includes Polymer Physics.