支持白藜芦醇在治疗常见呼吸道病原体中发挥作用的临床和临床前数据综述

IF 4.1 Q2 FOOD SCIENCE & TECHNOLOGY NFS Journal Pub Date : 2024-10-08 DOI:10.1016/j.nfs.2024.100194
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引用次数: 0

摘要

呼吸道感染是婴幼儿时期的一个重要问题,是发病率的主要来源,也给医疗系统带来了沉重的负担。支气管炎、肺炎和流感等疾病说明了这些感染在儿科人群中的严重性。在这一健康挑战的背景下,白藜芦醇这种天然多酚抗氧化剂因其抗氧化、抗炎和抗菌特性而成为广泛研究的焦点。本综述深入探讨了这种化合物对各种细菌和病毒的广泛抗菌活性,既可单独使用,也可与传统抗生素联合使用。该化合物对涉及严重呼吸道感染的病毒具有显著的抗病毒活性,提供了一种潜在的治疗途径。通过探索白藜芦醇的抗病毒机制并强调其抗炎潜力,本综述有助于加深对其在缓解与小儿呼吸道感染相关的复杂问题方面的适用性的理解。
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A review of clinical and preclinical data supporting a role for resveratrol in the treatment of common respiratory tract pathogens
Respiratory infections are a relevant issue during infancy and childhood, constituting a major source of morbidity and imposing a substantial burden on healthcare systems. Conditions such as bronchiolitis, pneumonia, and influenza exemplify the gravity of these infections among pediatric populations. In the context of this health challenge, resveratrol, a naturally occurring polyphenolic antioxidant has emerged as a focal point of extensive research, known for its antioxidant, anti-inflammatory, and antimicrobial properties. This comprehensive review delves into the compound's extensive antimicrobial activities against a diverse range of bacteria and viruses, both as a standalone agent and in combination with conventional antibiotics. This compound exhibits notable antiviral activity against viruses implicated in severe respiratory infections, offering a potential therapeutic avenue. By exploring the antiviral mechanisms and highlighting the anti-inflammatory potential of resveratrol, this comprehensive overview contributes to a deeper understanding of its applicability in mitigating the complexities associated with pediatric respiratory infections.
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来源期刊
NFS Journal
NFS Journal Agricultural and Biological Sciences-Food Science
CiteScore
11.10
自引率
0.00%
发文量
18
审稿时长
29 days
期刊介绍: The NFS Journal publishes high-quality original research articles and methods papers presenting cutting-edge scientific advances as well as review articles on current topics in all areas of nutrition and food science. The journal particularly invites submission of articles that deal with subjects on the interface of nutrition and food research and thus connect both disciplines. The journal offers a new form of submission Registered Reports (see below). NFS Journal is a forum for research in the following areas: • Understanding the role of dietary factors (macronutrients and micronutrients, phytochemicals, bioactive lipids and peptides etc.) in disease prevention and maintenance of optimum health • Prevention of diet- and age-related pathologies by nutritional approaches • Advances in food technology and food formulation (e.g. novel strategies to reduce salt, sugar, or trans-fat contents etc.) • Nutrition and food genomics, transcriptomics, proteomics, and metabolomics • Identification and characterization of food components • Dietary sources and intake of nutrients and bioactive compounds • Food authentication and quality • Nanotechnology in nutritional and food sciences • (Bio-) Functional properties of foods • Development and validation of novel analytical and research methods • Age- and gender-differences in biological activities and the bioavailability of vitamins, minerals, and phytochemicals and other dietary factors • Food safety and toxicology • Food and nutrition security • Sustainability of food production
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