Luis F. Tintinago-Londoño , Tania M. Guzmán , Estephania Candelo , Andrés Gempeler , Juan F. Vélez , Juan C. Arias , Walter Mosquera , William Victoria
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引用次数: 0
摘要
背景胸腺促进 T 细胞成熟，对免疫系统的发育至关重要。目前治疗先天性无胸腺症的方法通常包括异体胸腺组织的无血管移植。方法2022年6月至11月期间，我们在大学附属三级医院进行了一项可行性研究，对年龄在16天至17个月的先天性心脏病患者在矫正手术中切除并丢弃的7个胸腺进行了检查。结果血管造影分析表明，婴儿胸腺叶中的血管通路各不相同，动脉平均直径为 0.5 毫米，静脉平均直径为 0.8 毫米，两者都能充分灌注贝尔泽溶液。
Microsurgical assessment of thymus vascular anatomy
Background
The thymus is pivotal for immune system development by facilitating T-cell maturation. Current treatments for congenital athymia typically involve avascular transplantation of allogeneic thymic tissue. However, vascularizing an infant thymus for transplantation could offer improved outcomes, necessitating a detailed understanding of its vascular anatomy.
Method
Between June and November 2022, we conducted a feasibility study at our tertiary care university hospital, examining seven thymus glands that were surgically removed and discarded during corrective surgeries for congenital heart disease in patients aged 16 days to 17 months.
Results
Angiographic analysis revealed distinct vascular pathways in infant thymic lobes, with arteries averaging 0.5 mm and veins 0.8 mm in diameter, both showing adequate perfusion with Belzer solution.
Conclusion
These findings provide critical insights into the vascular anatomy of the infant thymus, underscoring its potential for microvascular revascularization and transplantation.
期刊介绍：
Translational Research in Anatomy is an international peer-reviewed and open access journal that publishes high-quality original papers. Focusing on translational research, the journal aims to disseminate the knowledge that is gained in the basic science of anatomy and to apply it to the diagnosis and treatment of human pathology in order to improve individual patient well-being. Topics published in Translational Research in Anatomy include anatomy in all of its aspects, especially those that have application to other scientific disciplines including the health sciences: • gross anatomy • neuroanatomy • histology • immunohistochemistry • comparative anatomy • embryology • molecular biology • microscopic anatomy • forensics • imaging/radiology • medical education Priority will be given to studies that clearly articulate their relevance to the broader aspects of anatomy and how they can impact patient care.Strengthening the ties between morphological research and medicine will foster collaboration between anatomists and physicians. Therefore, Translational Research in Anatomy will serve as a platform for communication and understanding between the disciplines of anatomy and medicine and will aid in the dissemination of anatomical research. The journal accepts the following article types: 1. Review articles 2. Original research papers 3. New state-of-the-art methods of research in the field of anatomy including imaging, dissection methods, medical devices and quantitation 4. Education papers (teaching technologies/methods in medical education in anatomy) 5. Commentaries 6. Letters to the Editor 7. Selected conference papers 8. Case Reports
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