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Mesorectum volumetry in males with rectal cancer: Variabilities observed in pre- and post-neoadjuvant radiotherapy imaging 男性直肠癌患者的中直肠容积测量:在新辅助放疗前后成像中观察到的差异
Q3 Medicine Pub Date : 2025-02-12 DOI: 10.1016/j.tria.2025.100387
D. Lamprecht , K. Baatjes , W. Begg , H. Fourie , A. Alblas , L. Witbooi , T. Forgan

Purpose

This study utilised magnetic resonance imaging (MRI) to describe the within population variations and the variability observed in the volumetry of the mesorectum pre- and post-neoadjuvant radiotherapy, prior to surgical intervention, in a South-African sample of males with rectal cancer.

Methodology

Nineteen pelvic MRI scans of males diagnosed with rectal cancer, who underwent neoadjuvant long-course radiotherapy (LCRT) or short-course radiotherapy (SCRT) prior to undergoing a total mesorectal excision (TME), were retrospectively reviewed and analysed. Mesorectal volume was calculated after contouring individual axial slices and creating a three-dimensional compounded structure on both pre- and post-radiotherapy scans, which were subsequently described and compared.

Results

Both pre- and post-neoadjuvant radiotherapy mesorectal volumetry displayed great variability. Mean calculated pre-radiotherapy mesorectal volume was 272.94 ± 80.30 cm3. Post-radiotherapy volume equated to 239.19 ± 81.30 cm3, presenting an overall percentage decrease of 12,60 %, resulting in a statistically significant difference (p = 0.001). In sub-group analysis, both patient groups who underwent LCRT and SCRT showed a general decrease and statistically significant difference in mesorectal volume post-radiotherapy when compared to pre-radiotherapy imaging.

Conclusion

Significant variation in the volumetry of the mesorectum pre- and post-neoadjuvant radiotherapy observable on MRI can have important clinical implications for the TME. A change in mesorectal morphometry may require modification of the planned surgical strategy. Therefore, the information obtained from a post-radiotherapy MRI prior to surgical intervention, can be a worthwhile addition to the available armamentarium for surgeons to guide surgical decision-making, encouraging the adoption of optimal individualized and novel treatment strategies to improve patient outcomes.
{"title":"Mesorectum volumetry in males with rectal cancer: Variabilities observed in pre- and post-neoadjuvant radiotherapy imaging","authors":"D. Lamprecht ,&nbsp;K. Baatjes ,&nbsp;W. Begg ,&nbsp;H. Fourie ,&nbsp;A. Alblas ,&nbsp;L. Witbooi ,&nbsp;T. Forgan","doi":"10.1016/j.tria.2025.100387","DOIUrl":"10.1016/j.tria.2025.100387","url":null,"abstract":"<div><h3>Purpose</h3><div>This study utilised magnetic resonance imaging (MRI) to describe the within population variations and the variability observed in the volumetry of the mesorectum pre- and post-neoadjuvant radiotherapy, prior to surgical intervention, in a South-African sample of males with rectal cancer.</div></div><div><h3>Methodology</h3><div>Nineteen pelvic MRI scans of males diagnosed with rectal cancer, who underwent neoadjuvant long-course radiotherapy (LCRT) or short-course radiotherapy (SCRT) prior to undergoing a total mesorectal excision (TME), were retrospectively reviewed and analysed. Mesorectal volume was calculated after contouring individual axial slices and creating a three-dimensional compounded structure on both pre- and post-radiotherapy scans, which were subsequently described and compared.</div></div><div><h3>Results</h3><div>Both pre- and post-neoadjuvant radiotherapy mesorectal volumetry displayed great variability. Mean calculated pre-radiotherapy mesorectal volume was 272.94 ± 80.30 cm<sup>3</sup>. Post-radiotherapy volume equated to 239.19 ± 81.30 cm<sup>3</sup>, presenting an overall percentage decrease of 12,60 %, resulting in a statistically significant difference (p = 0.001). In sub-group analysis, both patient groups who underwent LCRT and SCRT showed a general decrease and statistically significant difference in mesorectal volume post-radiotherapy when compared to pre-radiotherapy imaging.</div></div><div><h3>Conclusion</h3><div>Significant variation in the volumetry of the mesorectum pre- and post-neoadjuvant radiotherapy observable on MRI can have important clinical implications for the TME. A change in mesorectal morphometry may require modification of the planned surgical strategy. Therefore, the information obtained from a post-radiotherapy MRI prior to surgical intervention, can be a worthwhile addition to the available armamentarium for surgeons to guide surgical decision-making, encouraging the adoption of optimal individualized and novel treatment strategies to improve patient outcomes.</div></div>","PeriodicalId":37913,"journal":{"name":"Translational Research in Anatomy","volume":"39 ","pages":"Article 100387"},"PeriodicalIF":0.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143437970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The medial plica syndrome of the knee – Narrative review of the literature
Q3 Medicine Pub Date : 2025-02-09 DOI: 10.1016/j.tria.2025.100386
Szymon Gryckiewicz , Łukasz Paczesny , Anna Brożyna , Jan Zabrzyński , Agnieszka Gryckiewicz , Zofia Paradowska , Marek Libura
Synovial plicae are physiological tissue found in the knee joint. They are formed in the fetal period as remnants of synovial cavities that are not absorbed in the process of apoptosis. Depending on the location of the plica, medicine distinguishes several types of plicae - suprapatellar, infrapatellar, medial and the lateral one. Based on the shape and size of the fold, the types are divided into subtypes. In the knee joint, the most common is medial plica, which extends from the area of the articular muscle or the vastus medialis oblique muscle, which runs parallel to the medial femoral condyle and patella.
Medial plica syndrome (MPS) is the medical term for the development of sympthoms caused by a pathological synovial fold. A significant factor in the pathophysiology of medial plica syndrome is the stage of inflammation, occurring either in the direct injury mechanism of plica (e.g. torsional mechanism) or as a consequence of cumulative overload changes. Typical clinical symptoms of a patient with MPS include: dull pain in the antero-medial apspect of the knee, associated with repeated knee flexion movement with possible clicking or locking signs. Clinical provocation tests were described (Mediopatellar Plica Test, Hughston Fold Test, Stutter Test) to confirm the diagnosis. It is crucial to exclude the presence of other knee joint diseases.
Imaging including ultrasound and MRI may be useful in differential diagnosis but confirmation of the presence of the plica is not sufficient to make a diagnosis. Conservative treatment can be effective and it is based on NSAIDs administration, activity modification, kinesiotherapy and physical therapy. In the case of ineffective conservative treatment, arthroscopic surgery is considered. Usually larger folds in the MPS require surgical intervention.
{"title":"The medial plica syndrome of the knee – Narrative review of the literature","authors":"Szymon Gryckiewicz ,&nbsp;Łukasz Paczesny ,&nbsp;Anna Brożyna ,&nbsp;Jan Zabrzyński ,&nbsp;Agnieszka Gryckiewicz ,&nbsp;Zofia Paradowska ,&nbsp;Marek Libura","doi":"10.1016/j.tria.2025.100386","DOIUrl":"10.1016/j.tria.2025.100386","url":null,"abstract":"<div><div>Synovial plicae are physiological tissue found in the knee joint. They are formed in the fetal period as remnants of synovial cavities that are not absorbed in the process of apoptosis. Depending on the location of the plica, medicine distinguishes several types of plicae - suprapatellar, infrapatellar, medial and the lateral one. Based on the shape and size of the fold, the types are divided into subtypes. In the knee joint, the most common is medial plica, which extends from the area of the articular muscle or the vastus medialis oblique muscle, which runs parallel to the medial femoral condyle and patella.</div><div>Medial plica syndrome (MPS) is the medical term for the development of sympthoms caused by a pathological synovial fold. A significant factor in the pathophysiology of medial plica syndrome is the stage of inflammation, occurring either in the direct injury mechanism of plica (e.g. torsional mechanism) or as a consequence of cumulative overload changes. Typical clinical symptoms of a patient with MPS include: dull pain in the antero-medial apspect of the knee, associated with repeated knee flexion movement with possible clicking or locking signs. Clinical provocation tests were described (Mediopatellar Plica Test, Hughston Fold Test, Stutter Test) to confirm the diagnosis. It is crucial to exclude the presence of other knee joint diseases.</div><div>Imaging including ultrasound and MRI may be useful in differential diagnosis but confirmation of the presence of the plica is not sufficient to make a diagnosis. Conservative treatment can be effective and it is based on NSAIDs administration, activity modification, kinesiotherapy and physical therapy. In the case of ineffective conservative treatment, arthroscopic surgery is considered. Usually larger folds in the MPS require surgical intervention.</div></div>","PeriodicalId":37913,"journal":{"name":"Translational Research in Anatomy","volume":"39 ","pages":"Article 100386"},"PeriodicalIF":0.0,"publicationDate":"2025-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143387423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dynamic high resolution US as primary tool in comparison to MRI in evaluation of TMJ disk anterior displacement
Q3 Medicine Pub Date : 2025-01-30 DOI: 10.1016/j.tria.2025.100385
Ahmed Y. Ashour , Abdalwhab M.A. Zwiri , Ahmed H. Ali , Ahmed M. Mostafa , Bahaa-Eldin A. Moustafa , Husseini F. EL boraey , Alshimaa Y. Ashour , Elsayed M. Abd El-Hamid

Background

Many adults are affected by temporo-mandibular joint dysfunction (TMD). Several imaging modalities as Magnetic resonance imaging (MRI), computed tomography (CT), and traditional radiography were used to diagnose TMD. Among these modalities, dynamic high-resolution ultrasound (US) emerges as a potential non-invasive, radiation-free method.

Objective

This study aimed to compare the efficacy of US versus MRI in the assessment of TMJ displacement.

Methods

This study included forty patients with a clinical diagnosis of anterior disk displacement (ADD). The TMJ was imaged bilaterally using a 1.5 T MRI using a 2-mm slice width, in the sagittal and coronal planes 1–7 days after performing US. The diagnostic accuracy of the ultrasound was evaluated for disc displacement in contrast to MRI. For US the following metrics: sensitivity, specificity, accuracy, positive predictive value, and negative predictive value were used to compare the measurements versus MRI.

Results

Patients were 14 male and 26 female patients (mean age 29.36 ± 7.09 years) with a duration of ADD of 3.2 ± 1.7 months. The most common clinical indications were TMJ stiffness and discomfort (85 %), followed by limited mouth opening (75 %), and TMJ sounds (crepitus/clicking) (80 %). Most patients had mild TMJ dysfunction (44.0 ± 16.42). The MRI was better in identifying TMJ abnormalities than the US. However, no significant differences were observed. Compared to MRI, US showed superior diagnostic sensitivity, specificity, and accuracy for TMJ disc displacements.

Conclusions

According to the study's findings, US can be suggested as a very precise imaging method for identifying internal TMJ abnormalities.
{"title":"Dynamic high resolution US as primary tool in comparison to MRI in evaluation of TMJ disk anterior displacement","authors":"Ahmed Y. Ashour ,&nbsp;Abdalwhab M.A. Zwiri ,&nbsp;Ahmed H. Ali ,&nbsp;Ahmed M. Mostafa ,&nbsp;Bahaa-Eldin A. Moustafa ,&nbsp;Husseini F. EL boraey ,&nbsp;Alshimaa Y. Ashour ,&nbsp;Elsayed M. Abd El-Hamid","doi":"10.1016/j.tria.2025.100385","DOIUrl":"10.1016/j.tria.2025.100385","url":null,"abstract":"<div><h3>Background</h3><div>Many adults are affected by temporo-mandibular joint dysfunction (TMD). Several imaging modalities as Magnetic resonance imaging (MRI), computed tomography (CT), and traditional radiography were used to diagnose TMD. Among these modalities, dynamic high-resolution ultrasound (US) emerges as a potential non-invasive, radiation-free method.</div></div><div><h3>Objective</h3><div>This study aimed to compare the efficacy of US versus MRI in the assessment of TMJ displacement.</div></div><div><h3>Methods</h3><div>This study included forty patients with a clinical diagnosis of anterior disk displacement (ADD). The TMJ was imaged bilaterally using a 1.5 T MRI using a 2-mm slice width, in the sagittal and coronal planes 1–7 days after performing US. The diagnostic accuracy of the ultrasound was evaluated for disc displacement in contrast to MRI. For US the following metrics: sensitivity, specificity, accuracy, positive predictive value, and negative predictive value were used to compare the measurements versus MRI.</div></div><div><h3>Results</h3><div>Patients were 14 male and 26 female patients (mean age 29.36 ± 7.09 years) with a duration of ADD of 3.2 ± 1.7 months. The most common clinical indications were TMJ stiffness and discomfort (85 %), followed by limited mouth opening (75 %), and TMJ sounds (crepitus/clicking) (80 %). Most patients had mild TMJ dysfunction (44.0 ± 16.42). The MRI was better in identifying TMJ abnormalities than the US. However, no significant differences were observed. Compared to MRI, US showed superior diagnostic sensitivity, specificity, and accuracy for TMJ disc displacements.</div></div><div><h3>Conclusions</h3><div>According to the study's findings, US can be suggested as a very precise imaging method for identifying internal TMJ abnormalities.</div></div>","PeriodicalId":37913,"journal":{"name":"Translational Research in Anatomy","volume":"39 ","pages":"Article 100385"},"PeriodicalIF":0.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143140274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Feasibility of transpedicular screw placement through the posterior arch of C1: A CT study in the Emirati population
Q3 Medicine Pub Date : 2025-01-30 DOI: 10.1016/j.tria.2025.100384
Ivan James Prithishkumar , Dineshwary Suresh , Nerissa Naidoo , Rashid AlSharhan , Usama Al Bastaki , Jeyaseelan Lakshmanan , Baylis Vivek Joseph

Background

Instrumentation of the lateral mass of first cervical vertebra (C1) is required in atlantoaxial instability. C1 bears a complicated relationship with adjacent neurovascular structures such as the vertebral artery and cervical spinal cord, which are at risk of injury in a misplaced screw. The objective of this study was to look at the feasibility of transpedicular screw placement into the C1 lateral mass with entry through the posterior arch.

Methods

Computed tomography images of the cervical spine in 160 adults (>18 years) who are natives of the United Arab Emirates (UAE) (M = 80; F = 80) were reviewed. Morphometric parameters relevant to pedicle screw fixation via the posterior arch were studied.

Results

Mean intraosseous distance from screw entry point in the posterior arch to the anterior cortex of lateral mass following a straight course without any inclination was 28.0 mm in males and 29.0 mm in females, allowing a safe distance of 3.2 mm from the foramen transversarium laterally and 9.0 mm from the vertebral canal medially. A medial inclination of 18° in males and 14° in females allows for increased bone purchase. Mean height of the pedicle at its junction with lateral mass was 5.6 mm in both sexes. However, the mean height of the posterior arch at the vertebral artery groove was 3.3 ± 0.4 mm in males and 3.1 ± 0.4 mm in females.

Conclusion

We recommend placement of 3.5/4.0 mm screws using the notching technique, of length 28–30 mm with a slight medial angulation of 15° for increased bone purchase and greater stability of fixation.
{"title":"Feasibility of transpedicular screw placement through the posterior arch of C1: A CT study in the Emirati population","authors":"Ivan James Prithishkumar ,&nbsp;Dineshwary Suresh ,&nbsp;Nerissa Naidoo ,&nbsp;Rashid AlSharhan ,&nbsp;Usama Al Bastaki ,&nbsp;Jeyaseelan Lakshmanan ,&nbsp;Baylis Vivek Joseph","doi":"10.1016/j.tria.2025.100384","DOIUrl":"10.1016/j.tria.2025.100384","url":null,"abstract":"<div><h3>Background</h3><div>Instrumentation of the lateral mass of first cervical vertebra (C1) is required in atlantoaxial instability. C1 bears a complicated relationship with adjacent neurovascular structures such as the vertebral artery and cervical spinal cord, which are at risk of injury in a misplaced screw. The objective of this study was to look at the feasibility of transpedicular screw placement into the C1 lateral mass with entry through the posterior arch.</div></div><div><h3>Methods</h3><div>Computed tomography images of the cervical spine in 160 adults (&gt;18 years) who are natives of the United Arab Emirates (UAE) (M = 80; F = 80) were reviewed. Morphometric parameters relevant to pedicle screw fixation via the posterior arch were studied.</div></div><div><h3>Results</h3><div>Mean intraosseous distance from screw entry point in the posterior arch to the anterior cortex of lateral mass following a straight course without any inclination was 28.0 mm in males and 29.0 mm in females, allowing a safe distance of 3.2 mm from the foramen transversarium laterally and 9.0 mm from the vertebral canal medially. A medial inclination of 18° in males and 14° in females allows for increased bone purchase. Mean height of the pedicle at its junction with lateral mass was 5.6 mm in both sexes. However, the mean height of the posterior arch at the vertebral artery groove was 3.3 ± 0.4 mm in males and 3.1 ± 0.4 mm in females.</div></div><div><h3>Conclusion</h3><div>We recommend placement of 3.5/4.0 mm screws using the notching technique, of length 28–30 mm with a slight medial angulation of 15° for increased bone purchase and greater stability of fixation.</div></div>","PeriodicalId":37913,"journal":{"name":"Translational Research in Anatomy","volume":"39 ","pages":"Article 100384"},"PeriodicalIF":0.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143199078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stature estimation and sex determination from contemporary Northeastern Thai clavicles using discriminant function and linear regression analyses
Q3 Medicine Pub Date : 2025-01-06 DOI: 10.1016/j.tria.2025.100383
Chanasorn Poodendaen , Poonikha Namwongsakool , Sitthichai Iamsaard , Nareelak Tangsrisakda , Rarinthron Samrid , Chadaporn Chaimontri , Worrawit Boonthai , Suthat Duangchit

Background

Reliable methods for stature estimation and sex determination are still needed for anthropologists to identify other skeletal remains for applying in forensic cases when the skull or pelvis disappears or is severely damaged. The clavicle is known to have high sexual dimorphism because of its anatomical features including size and shape. High variability of clavicle has significant forensic application in many populations except the modern Northeastern Thais. This study aimed to develop the discriminant function analysis to estimate stature and sex dimorphism from dry clavicles in exploring a potential method for Thai forensic anthropology.

Materials and method

Four hundred dry clavicles (200 males, 200 females) identified for sex and height before body donation were measured for six standardized parameters including maximum length of clavicle (MaxL), anterior-posterior width at the acromion end surface (APA), anterior-posterior width at the sternal end surface (APS), superior-inferior width at the acromion end surface (SIA), superior-inferior width at the sternal end surface (SIS), and circumference at the mid-shaft of clavicle (CirMid), respectively. The discriminant function and regression analyses were used for sex determination and stature estimation.

Results

All parameters showed significant difference of sexual dimorphism with greater in male dimensions compared to those of females (p < 0.01). For sex determination using univariate analysis, the most accuracy rate was of MaxL (83.5 %). In stepwise discriminant function analysis, the four parameters of MaxL, APS, SIS, and CirMid on the right side could enhance the accuracy rate up to 88.5 %. The highest correlation of stature estimation was observed in the combined-sex analysis (r = 0.73, R2 = 0.54, SEE = 5.78 cm) by using only right MaxL and CirMid parameters.

Conclusion

Multi-variable discriminant functions provide more reliability in sex determination while the combined-sex equations is the most effective method to estimate stature for contemporary Northeastern Thais. This novel method can be used to apply in the forensic anthropological analysis for Thai clavicle remain.
{"title":"Stature estimation and sex determination from contemporary Northeastern Thai clavicles using discriminant function and linear regression analyses","authors":"Chanasorn Poodendaen ,&nbsp;Poonikha Namwongsakool ,&nbsp;Sitthichai Iamsaard ,&nbsp;Nareelak Tangsrisakda ,&nbsp;Rarinthron Samrid ,&nbsp;Chadaporn Chaimontri ,&nbsp;Worrawit Boonthai ,&nbsp;Suthat Duangchit","doi":"10.1016/j.tria.2025.100383","DOIUrl":"10.1016/j.tria.2025.100383","url":null,"abstract":"<div><h3>Background</h3><div>Reliable methods for stature estimation and sex determination are still needed for anthropologists to identify other skeletal remains for applying in forensic cases when the skull or pelvis disappears or is severely damaged. The clavicle is known to have high sexual dimorphism because of its anatomical features including size and shape. High variability of clavicle has significant forensic application in many populations except the modern Northeastern Thais. This study aimed to develop the discriminant function analysis to estimate stature and sex dimorphism from dry clavicles in exploring a potential method for Thai forensic anthropology.</div></div><div><h3>Materials and method</h3><div>Four hundred dry clavicles (200 males, 200 females) identified for sex and height before body donation were measured for six standardized parameters including maximum length of clavicle (MaxL), anterior-posterior width at the acromion end surface (APA), anterior-posterior width at the sternal end surface (APS), superior-inferior width at the acromion end surface (SIA), superior-inferior width at the sternal end surface (SIS), and circumference at the mid-shaft of clavicle (CirMid), respectively. The discriminant function and regression analyses were used for sex determination and stature estimation.</div></div><div><h3>Results</h3><div>All parameters showed significant difference of sexual dimorphism with greater in male dimensions compared to those of females (p &lt; 0.01). For sex determination using univariate analysis, the most accuracy rate was of MaxL (83.5 %). In stepwise discriminant function analysis, the four parameters of MaxL, APS, SIS, and CirMid on the right side could enhance the accuracy rate up to 88.5 %. The highest correlation of stature estimation was observed in the combined-sex analysis (r = 0.73, R<sup>2</sup> = 0.54, SEE = 5.78 cm) by using only right MaxL and CirMid parameters.</div></div><div><h3>Conclusion</h3><div>Multi-variable discriminant functions provide more reliability in sex determination while the combined-sex equations is the most effective method to estimate stature for contemporary Northeastern Thais. This novel method can be used to apply in the forensic anthropological analysis for Thai clavicle remain.</div></div>","PeriodicalId":37913,"journal":{"name":"Translational Research in Anatomy","volume":"38 ","pages":"Article 100383"},"PeriodicalIF":0.0,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143149640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Variation of lung fissure completeness and sex-based differences in lung anatomy using cadaveric lungs
Q3 Medicine Pub Date : 2025-01-03 DOI: 10.1016/j.tria.2025.100382
Nicholas R. Stange, Shivika Ahuja, Daniel T. Daly, Yun Tan
The gross anatomy of human lungs is relatively consistent; however, previous studies have noted variations in the degree of fissure completeness as well as sex-based differences in lung size and shape. In this study, 90 cadaveric lungs obtained through the Gift Body Program of Saint Louis University School of Medicine were used to describe the linear dimensions and fissure completeness of fixed cadaveric lungs, provide a detailed and reproducible method of measuring dimensions of lungs, and describe sex-related differences in lung dimensions. This study adds to the existing body of knowledge of lung anatomy from studies conducted via CT imaging, thoracic dimension analysis, pulmonary function testing, and other cadaveric studies. For dimensional analysis and fissure completeness, the right horizontal fissure exhibited the most variations in the fissures of the lung. For sex-based differences, female left lungs had a similar height, a narrower base, and a more oblique angle when compared to male lungs. No significant differences in oblique angle, horizontal angle or width to height ratios were observed. This is the first cadaveric study to demonstrate sex-based differences in human lungs and supports the reliability of using cadaveric specimens to study the clinical implications of anatomical variations.
{"title":"Variation of lung fissure completeness and sex-based differences in lung anatomy using cadaveric lungs","authors":"Nicholas R. Stange,&nbsp;Shivika Ahuja,&nbsp;Daniel T. Daly,&nbsp;Yun Tan","doi":"10.1016/j.tria.2025.100382","DOIUrl":"10.1016/j.tria.2025.100382","url":null,"abstract":"<div><div>The gross anatomy of human lungs is relatively consistent; however, previous studies have noted variations in the degree of fissure completeness as well as sex-based differences in lung size and shape. In this study, 90 cadaveric lungs obtained through the Gift Body Program of Saint Louis University School of Medicine were used to describe the linear dimensions and fissure completeness of fixed cadaveric lungs, provide a detailed and reproducible method of measuring dimensions of lungs, and describe sex-related differences in lung dimensions. This study adds to the existing body of knowledge of lung anatomy from studies conducted via CT imaging, thoracic dimension analysis, pulmonary function testing, and other cadaveric studies. For dimensional analysis and fissure completeness, the right horizontal fissure exhibited the most variations in the fissures of the lung. For sex-based differences, female left lungs had a similar height, a narrower base, and a more oblique angle when compared to male lungs. No significant differences in oblique angle, horizontal angle or width to height ratios were observed. This is the first cadaveric study to demonstrate sex-based differences in human lungs and supports the reliability of using cadaveric specimens to study the clinical implications of anatomical variations.</div></div>","PeriodicalId":37913,"journal":{"name":"Translational Research in Anatomy","volume":"38 ","pages":"Article 100382"},"PeriodicalIF":0.0,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143149639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Laterally positioned external carotid arteries: Two cadaveric case reports
Q3 Medicine Pub Date : 2024-12-29 DOI: 10.1016/j.tria.2024.100381
Kara Coffman-Rea , Skylar Arwood , Karen E. Samonds , Dylan J. Fuchs , Julia P. Negrin
Anatomical variations in the carotid vasculature are clinically significant due to their implications for various surgical procedures and their potential to produce a range of symptoms. This case report highlights two notable variations observed during routine cadaveric dissections. In both cases, the external carotid artery was positioned laterally. Both cases presented the superior thyroid artery and superior laryngeal artery branching at the level of the carotid bifurcation; one case showed both arteries originating directly from the bifurcation, while the other case exhibited the typical branching pattern where the superior laryngeal artery branches from the superior thyroid artery. One case also included a high carotid bifurcation above the typical location at the superior border of the thyroid cartilage.
{"title":"Laterally positioned external carotid arteries: Two cadaveric case reports","authors":"Kara Coffman-Rea ,&nbsp;Skylar Arwood ,&nbsp;Karen E. Samonds ,&nbsp;Dylan J. Fuchs ,&nbsp;Julia P. Negrin","doi":"10.1016/j.tria.2024.100381","DOIUrl":"10.1016/j.tria.2024.100381","url":null,"abstract":"<div><div>Anatomical variations in the carotid vasculature are clinically significant due to their implications for various surgical procedures and their potential to produce a range of symptoms. This case report highlights two notable variations observed during routine cadaveric dissections. In both cases, the external carotid artery was positioned laterally. Both cases presented the superior thyroid artery and superior laryngeal artery branching at the level of the carotid bifurcation; one case showed both arteries originating directly from the bifurcation, while the other case exhibited the typical branching pattern where the superior laryngeal artery branches from the superior thyroid artery. One case also included a high carotid bifurcation above the typical location at the superior border of the thyroid cartilage.</div></div>","PeriodicalId":37913,"journal":{"name":"Translational Research in Anatomy","volume":"38 ","pages":"Article 100381"},"PeriodicalIF":0.0,"publicationDate":"2024-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143148793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical implications of the hepatomesenteric trunk–case report and literature review
Q3 Medicine Pub Date : 2024-12-08 DOI: 10.1016/j.tria.2024.100380
Mark Shacker , Artur Rybachok , Benjamin R. Paul , Manuel Cevallos

Purpose

Variants of the abdominal vasculature profoundly impact the fields of interventional radiology and surgery. The “hepatomesenteric trunk” is a unique abdominal variant wherein the common hepatic artery arises directly from the superior mesenteric artery.

Methods

A narrative literature review was conducted to thoroughly characterize the hepatomesenteric trunk, including its reported prevalence, embryological origin, and implications in clinical practice. A detailed description of this variant found in a donor was also presented.

Results

The prevalence of the hepatomesenteric trunk ranges from 1.0 to 4.5 % in ten comprehensive studies. In as many as 90 % of cases, the hepatomesenteric trunk may be accompanied by a “gastrosplenic trunk,” wherein the left gastric and splenic arteries share a common origin.

Significance

This variant uniquely impacts foregut and midgut perfusion, and knowledge of this and other splanchnic arterial variants is essential for procedures such as pancreaticoduodenectomy, arterial reconstruction, mesenteric revascularization, and transarterial chemoembolization. A detailed preoperative workup, meticulously planned surgical approach, and comprehensive knowledge of such variants are essential to mitigate the risk of vascular injury in abdominal procedures.
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引用次数: 0
The discovery of high endothelial venules. A historical note
Q3 Medicine Pub Date : 2024-12-03 DOI: 10.1016/j.tria.2024.100379
Domenico Ribatti

Background

Endothelial cells are a heterogeneous population. There are differences between the different species' endothelium, large and small vessels, and between endothelial cells derived from various microvascular endothelial beds. In this context, endothelial cells of high endothelial venules (HEVs) represent an extremely interesting and not-yet completely investigated cell population.

Methods

A literature search in PubMed on the history of HEVs was conducted. The keywords used in the search criteria were “High endothelial venules,” “Immunity,” “B lymphocytes,” “T lymphocytes,” and “Lymph nodes.” The results were summarized in a short narrative historical review based on published papers on the role of HEVs in immunity, inflammation, and cancer.

Results

HEVs are morphologically characterized by a plump, almost cuboidal appearance, a rounded nucleus, a thicker basement membrane, and a layer of mesenchymal cells outside the basement membrane. HEVs are specialized blood vessels mediating lymphocyte trafficking to lymph nodes and other secondary lymphoid organs. HEVs expand during inflammation in immune-stimulated lymph nodes and are profoundly remodeled in metastatic and tumor-draining lymph nodes.

Conclusion

This article emphasizes the important role of HEVs in immunity, inflammation, and cancer. However, although many aspects of HEVs are still to be discovered, their therapeutic modulation already offers interesting results, especially for cancer treatment.
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引用次数: 0
Median nerve piercing the humeral head of pronator teres muscle: An anatomical case report of atypical median nerve formation and course 正中神经穿透肱骨头的旋前肌:关于非典型正中神经形成和走向的解剖病例报告
Q3 Medicine Pub Date : 2024-11-20 DOI: 10.1016/j.tria.2024.100377
Y. Lakshmisha Rao , Archi Raj , Mangala M. Pai , Mamatha Tonse , Jasmeen Kaur , J.M. Likitha , B.V. Murlimanju

Introduction

The objective of this study is to report the variant formation and course of the median nerve, which was observed in the right arm of a male cadaver.

Methods

During the routine dissection procedure, it was observed that the median nerve was formed by the blending of three roots, which included one medial and two lateral roots.

Results

It is also further observed that the median nerve pierced the humeral head of pronator teres just above the medial epicondyle and it passed through the cubital fossa more medially and deeper, making it invisible.

Conclusion

Entrapment of median nerve by the pronator teres is among the causes of the proximal median nerve entrapment syndrome. In this context, this interesting and rare variation of pronator teres muscle being pierced by the median nerve will be of interest to the orthopedic specialists, neurosurgeons and hand surgeons. The present study also observed variant formation of the median nerve by triple roots, which is important both for the surgical and anesthesiologic perspective.
方法在常规解剖过程中,观察到正中神经由三条神经根混合形成,其中包括一条内侧神经根和两条外侧神经根。结果还进一步观察到,正中神经正好在内侧上髁上方刺穿了肱骨头的发音肌,并在更内侧和更深的位置穿过了肘窝,使其变得不可见。在这种情况下,骨科专家、神经外科医生和手外科医生会对这一有趣而罕见的正中神经穿刺发音肌变异感兴趣。本研究还观察到正中神经由三根形成的变异,这对手术和麻醉学角度都很重要。
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引用次数: 0
期刊
Translational Research in Anatomy
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