微波辅助提取大麻花序中的植物化学物质与 2-甲基环氧乙烷

IF 5.5 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY Sustainable Chemistry and Pharmacy Pub Date : 2024-10-16 DOI:10.1016/j.scp.2024.101812

{"title":"微波辅助提取大麻花序中的植物化学物质与 2-甲基环氧乙烷","authors":"","doi":"10.1016/j.scp.2024.101812","DOIUrl":null,"url":null,"abstract":"<div><div>2-methyltetrahydrofuran, also known as 2-methyloxolane (2-MeOx), was investigated for the extraction of phytochemicals from <em>Cannabis sativa</em> L. inflorescences. Dynamic maceration with 2-MeOx yielded comparable CBD (75.45 mg CBD/g DM) to ethanol (77.71 mg) and hexane (75.09 mg). The use of water-saturated 2-MeOx (4.5% water) increased the CBD recovery to 81.30 mg/g DM and the polyphenols content. 2-MeOx was also a good solvent for the recovery of hemp terpenes (87906−120485 mg/kg extract). Microwave-assisted extraction improved the CBD yield and shortened the time (by 3–30 times). Optimised microwave conditions resulted in higher CBD yields (84.18−86.76 mg CBD/g DM) compared to conventional extraction. Microwave-assisted decarboxylation-extraction with 2-MeOx was less effective than ethanol for CBDA decarboxylation (about 3–10 times lower). Finally, a single-mode microwave reactor for flow extraction was tested, achieving 75.48 mg CBD/g DM with 2-MeOx (3.65% water) at 60 °C in 10 min. Further optimisation is required for continuous microwave extraction with 2-MeOx.</div></div>","PeriodicalId":22138,"journal":{"name":"Sustainable Chemistry and Pharmacy","volume":null,"pages":null},"PeriodicalIF":5.5000,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Microwave-assisted extraction of phytochemicals from Cannabis sativa L. inflorescences with 2-methyloxolane\",\"authors\":\"\",\"doi\":\"10.1016/j.scp.2024.101812\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>2-methyltetrahydrofuran, also known as 2-methyloxolane (2-MeOx), was investigated for the extraction of phytochemicals from <em>Cannabis sativa</em> L. inflorescences. Dynamic maceration with 2-MeOx yielded comparable CBD (75.45 mg CBD/g DM) to ethanol (77.71 mg) and hexane (75.09 mg). The use of water-saturated 2-MeOx (4.5% water) increased the CBD recovery to 81.30 mg/g DM and the polyphenols content. 2-MeOx was also a good solvent for the recovery of hemp terpenes (87906−120485 mg/kg extract). Microwave-assisted extraction improved the CBD yield and shortened the time (by 3–30 times). Optimised microwave conditions resulted in higher CBD yields (84.18−86.76 mg CBD/g DM) compared to conventional extraction. Microwave-assisted decarboxylation-extraction with 2-MeOx was less effective than ethanol for CBDA decarboxylation (about 3–10 times lower). Finally, a single-mode microwave reactor for flow extraction was tested, achieving 75.48 mg CBD/g DM with 2-MeOx (3.65% water) at 60 °C in 10 min. Further optimisation is required for continuous microwave extraction with 2-MeOx.</div></div>\",\"PeriodicalId\":22138,\"journal\":{\"name\":\"Sustainable Chemistry and Pharmacy\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":5.5000,\"publicationDate\":\"2024-10-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Sustainable Chemistry and Pharmacy\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2352554124003875\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Sustainable Chemistry and Pharmacy","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2352554124003875","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

摘要

研究了从大麻（Cannabis sativa L.）花序中提取植物化学物质的 2-甲基四氢呋喃（又称 2-甲基氧杂环戊烷（2-MeOx））。用 2-MeOx 进行动态浸渍提取出的 CBD（75.45 毫克 CBD/克 DM）与乙醇（77.71 毫克）和正己烷（75.09 毫克）相当。使用水饱和的 2-MeOx（4.5% 水）可将 CBD 回收率提高到 81.30 毫克/克 DM，并增加多酚含量。2-MeOx 也是回收大麻萜烯（87906-120485 毫克/千克提取物）的良好溶剂。微波辅助萃取提高了 CBD 的产量，缩短了时间（3-30 倍）。与传统提取法相比，优化的微波条件可提高 CBD 产量（84.18-86.76 毫克 CBD/克 DM）。使用 2-MeOx 进行微波辅助脱羧萃取的 CBDA 脱羧效果不如乙醇（低约 3-10 倍）。最后，对用于流动萃取的单模式微波反应器进行了测试，在 60 °C 条件下，用 2-MeOx（3.65% 水）在 10 分钟内萃取出 75.48 毫克 CBD/克 DM。使用 2-MeOx 进行连续微波萃取还需要进一步优化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

摘要图片

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

Microwave-assisted extraction of phytochemicals from Cannabis sativa L. inflorescences with 2-methyloxolane

2-methyltetrahydrofuran, also known as 2-methyloxolane (2-MeOx), was investigated for the extraction of phytochemicals from Cannabis sativa L. inflorescences. Dynamic maceration with 2-MeOx yielded comparable CBD (75.45 mg CBD/g DM) to ethanol (77.71 mg) and hexane (75.09 mg). The use of water-saturated 2-MeOx (4.5% water) increased the CBD recovery to 81.30 mg/g DM and the polyphenols content. 2-MeOx was also a good solvent for the recovery of hemp terpenes (87906−120485 mg/kg extract). Microwave-assisted extraction improved the CBD yield and shortened the time (by 3–30 times). Optimised microwave conditions resulted in higher CBD yields (84.18−86.76 mg CBD/g DM) compared to conventional extraction. Microwave-assisted decarboxylation-extraction with 2-MeOx was less effective than ethanol for CBDA decarboxylation (about 3–10 times lower). Finally, a single-mode microwave reactor for flow extraction was tested, achieving 75.48 mg CBD/g DM with 2-MeOx (3.65% water) at 60 °C in 10 min. Further optimisation is required for continuous microwave extraction with 2-MeOx.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Sustainable Chemistry and Pharmacy Environmental Science-Pollution

CiteScore

8.20

自引率

6.70%

发文量

274

审稿时长

37 days

期刊介绍： Sustainable Chemistry and Pharmacy publishes research that is related to chemistry, pharmacy and sustainability science in a forward oriented manner. It provides a unique forum for the publication of innovative research on the intersection and overlap of chemistry and pharmacy on the one hand and sustainability on the other hand. This includes contributions related to increasing sustainability of chemistry and pharmaceutical science and industries itself as well as their products in relation to the contribution of these to sustainability itself. As an interdisciplinary and transdisciplinary journal it addresses all sustainability related issues along the life cycle of chemical and pharmaceutical products form resource related topics until the end of life of products. This includes not only natural science based approaches and issues but also from humanities, social science and economics as far as they are dealing with sustainability related to chemistry and pharmacy. Sustainable Chemistry and Pharmacy aims at bridging between disciplines as well as developing and developed countries.