五个非洲原住民的瘦素-脂联素比率和 HOMA-IR 与代谢综合征之间的关系。

IF 4.2 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM International Journal of Obesity Pub Date : 2024-10-17 DOI:10.1038/s41366-024-01655-8
Nadia Sweis, Julianne Jorgensen, Julia Zeng, Candice Choo-Kang, Joseph Zapater, Kweku Bedu-Addo, Terrence Forrester, Pascal Bovet, Estelle V Lambert, Walter Riesen, Wolfgang Korte, Yang Dai, Lara R Dugas, Brian T Layden, Amy Luke
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引用次数: 0

摘要

研究目的这项横断面研究旨在评估五个非洲裔人群的血清瘦素、脂肪连素、瘦素与脂肪连素比率(L/A 比率)、代谢综合征(MS)与 HOMA-IR 之间的关联:方法:临床测量包括血清葡萄糖、胰岛素、脂肪因子、血压和人体测量。多发性硬化症是根据统一标准确定的。最终样本包括 2087 名成年人:结果:在对年龄、性别和脂肪量进行调整后,与 HOMA-IR 不同的是,L/A 比值与所有部位的 MS 都有显著相关性(p 结论:我们的研究表明,非洲人的 L/A 比值与 MS 有显著相关性:我们的研究表明,散居在不同地理位置的非洲人在多发性硬化症的决定因素方面可能存在差异。未来的研究应调查不同非洲裔人群中 MS、IS 和脂肪因子之间不同关系的决定因素。
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The relationship between leptin-to-adiponectin ratio and HOMA-IR and metabolic syndrome in five African-origin populations.

Objective: This cross-sectional study aims to assess the associations between serum leptin, adiponectin, leptin-to-adiponectin ratio (L/A ratio), and metabolic syndrome (MS) and HOMA-IR in five African-origin populations: Ghana, South Africa, Jamaica, Seychelles, and US.

Methods: Clinical measures included serum glucose, insulin, adipokines, blood pressure and anthropometric measures. MS was determined using the Harmonized criteria. The final sample included 2087 adults.

Results: After adjusting for age, sex, and fat mass, L/A ratio, unlike HOMA-IR, was significantly associated with MS across all sites (p < 0.001). Within sites, L/A ratio was only associated with MS and HOMA-IR in the US (p < 0.001) and South Africa (p < 0.01), respectively. Leptin was associated with MS in South Africa only (p < 0.05) but was significantly associated with HOMA-IR across all five sites and within the US (p < 0.05). Similarly, adiponectin was associated with HOMA-IR in South Africa (p < 0.05) and with MS across all five sites (p < 0.001) and within each site separately, except Ghana.

Conclusions: Our study suggests that individuals of the African diaspora in different geographical locations may differ in the determinants of MS. Future studies should investigate the determinants for the disparate relationships between MS, IS and adipokines across different African-origin populations.

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来源期刊
International Journal of Obesity
International Journal of Obesity 医学-内分泌学与代谢
CiteScore
10.00
自引率
2.00%
发文量
221
审稿时长
3 months
期刊介绍: The International Journal of Obesity is a multi-disciplinary forum for research describing basic, clinical and applied studies in biochemistry, physiology, genetics and nutrition, molecular, metabolic, psychological and epidemiological aspects of obesity and related disorders. We publish a range of content types including original research articles, technical reports, reviews, correspondence and brief communications that elaborate on significant advances in the field and cover topical issues.
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