妊娠大于 31 周的新生儿重症监护室患者接受输血的次数以及慢性肺病的发病率和严重程度。

IF 2.4 3区医学 Q2 OBSTETRICS & GYNECOLOGY Journal of Perinatology Pub Date : 2024-10-15 DOI:10.1038/s41372-024-02135-7

Timothy M Bahr, Robin K Ohls, Erick Henry, Patricia Davenport, Sarah J Ilstrup, Walter E Kelley, Bradley A Yoder, Martha C Sola-Visner, Robert D Christensen

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引用次数: 0

摘要

目的：我们曾报道过，在出生不足 29 周的婴儿中，输血可能是支气管肺发育不良的致病因素。本研究对出生大于 31 周的婴儿进行了研究：研究设计：分析五个新生儿重症监护病房为出生大于 31 周的婴儿输注红细胞（RBC）和血小板的情况，以及婴儿六周大时的慢性新生儿肺部疾病（CNLD）：有 751 名出生超过 31 周的婴儿在六周大时仍在新生儿重症监护室。有 397 名婴儿（53%）被确诊为 CNLD。在控制了潜在的混杂因素后，输注红细胞和血小板与 CNLD 有独立的相关性。每输血一次，患 CNLD 的调整后几率就会增加 1.64 倍（95% CI，1.38-2.02；P 结论：在出生日期大于 31 周的新生儿重症监护病房患者中，每输血一次，患 CNLD 的几率就会增加 1.64 倍：在出生大于 31 周的新生儿重症监护病房患者中，6 周前接受的输血与 CNLD 的发生率和严重程度有关。虽然我们在回归模型中控制了已知的混杂变量，但病情严重程度是一个重要的混杂因素，限制了我们的结论。

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The number of blood transfusions received and the incidence and severity of chronic lung disease among NICU patients born >31 weeks gestation.

Objective: We previously reported the possible pathogenic role, among infants born ≤29 weeks, of transfusions in bronchopulmonary dysplasia. The present study examined this association in infants born >31 weeks.

Study design: Analysis of red blood cell (RBC) and platelet transfusions in five NICUs to infants born >31 weeks, and chronic neonatal lung disease (CNLD) at six-weeks of age.

Results: Seven-hundred-fifty-one infants born >31 weeks were still in the NICU when six-weeks of age. CNLD was identified in 397 (53%). RBC and platelet transfusions were independently associated with CNLD after controlling for potential confounders. For every transfusion, the adjusted odds of developing CNLD increased by a factor of 1.64 (95% CI, 1.38-2.02; p < 0.001).

Conclusions: Among NICU patients born >31 weeks, transfusions received by six weeks are associated with CNLD incidence and severity. Though we controlled for known confounding variables in our regression models, severity of illness is an important confounder that limits our conclusions.

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来源期刊

Journal of Perinatology 医学-妇产科学

CiteScore

5.40

自引率

6.90%

发文量

284

审稿时长

3-8 weeks

期刊介绍： The Journal of Perinatology provides members of the perinatal/neonatal healthcare team with original information pertinent to improving maternal/fetal and neonatal care. We publish peer-reviewed clinical research articles, state-of-the art reviews, comments, quality improvement reports, and letters to the editor. Articles published in the Journal of Perinatology embrace the full scope of the specialty, including clinical, professional, political, administrative and educational aspects. The Journal also explores legal and ethical issues, neonatal technology and product development. The Journal’s audience includes all those that participate in perinatal/neonatal care, including, but not limited to neonatologists, perinatologists, perinatal epidemiologists, pediatricians and pediatric subspecialists, surgeons, neonatal and perinatal nurses, respiratory therapists, pharmacists, social workers, dieticians, speech and hearing experts, other allied health professionals, as well as subspecialists who participate in patient care including radiologists, laboratory medicine and pathologists.