[血清 SAA、CRP、PCT、WBC 和 N% 在新生儿败血症诊断中的应用]。

Q Yang, J Fang, Y Xu, Y Yang, X H Yan
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One-way analysis of variance and Kruskal-Wallis <i>H</i> test were used to compare the general data and inflammatory index levels of the three groups of children. The correlation analysis between SAA and other inflammatory indicators was conducted using Spearman correlation analysis. The receiver operating characteristic (ROC) curve was used to determine the diagnostic efficacy of different inflammatory indicators for patients with definitely diagnosed septicemia and those with clinically diagnosed septicemia, and for those with clinically diagnosed septicemia and those without infection. The results showed that the levels of WBC [(16.88±5.64)×10<sup>9</sup>/L], N% [70.00 (63.00, 75.00)], PCT [2.22 (1.20, 5.55) mg/L], CRP [3.00 (0.50, 10.30) mg/L], SAA [19.70 (10.82, 49.90) mg/L] in the clinically diagnosed septicemia group and WBC [(16.10±7.48)×10<sup>9</sup>/L], N% [73.50 (61.50, 80.93)], PCT [5.35 (0.69, 20.07) mg/L], CRP [15.52 (4.98, 30.50) mg/L], SAA [43.95 (14.00, 175.98) mg/L] in the definitely diagnosed septicemia group were all higher than those in the control group (11.17±3.38)×10<sup>9</sup>/L, 49.81 (36.93, 62.75), 0.20 (0.07, 0.99) mg/L, 0.54 (0.20, 1.40) mg/L, 5.15 (3.60, 8.68) mg/L, and the differences were all statistically significant (all <i>P<</i>0.05). Spearman correlation analysis showed that the level of SAA was positively correlated with WBC, N%, PCT and CRP (<i>r</i><sub>s</sub>=0.453, 0.540, 0.343, 0.550, all <i>P</i><0.05). ROC curve analysis showed that the area under ROC curve(AUC) of SAA for the definitely diagnosed septicemia group and the clinically diagnosed septicemia group was higher than that of other inflammatory indicators, among them, the AUC of SAA for diagnosing the definitely diagnosed neonatal septicemia group was 0.933 (95%<i>CI</i>: 0.809-1.000, <i>P</i><0.05), with a sensitivity of 92.90% and a specificity of 99.30%. The AUC of SAA for diagnosing the clinically diagnosed septicemia group was 0.861 (95%<i>CI</i>: 0.818-0.904, <i>P</i><0.05), with a sensitivity of 83.20% and a specificity of 81.80%. In conclusion, compared with CRP, PCT, WBC and N%, SAA has higher sensitivity and specificity for distinguishing neonatal septicemia (including definitely diagnosed septicemia and clinically diagnosed septicemia), and has certain auxiliary diagnostic value for neonatal septicemia.</p>","PeriodicalId":24033,"journal":{"name":"中华预防医学杂志","volume":"58 10","pages":"1587-1592"},"PeriodicalIF":0.0000,"publicationDate":"2024-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Application of serum SAA, CRP, PCT, WBC and N% in the diagnosis of neonatal septicemia].\",\"authors\":\"Q Yang, J Fang, Y Xu, Y Yang, X H Yan\",\"doi\":\"10.3760/cma.j.cn112150-20240709-00550\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>To explore the application value of SAA (serum amyloid A), CRP (C reactive protein), PCT (procalcitonin), WBC (white blood cell) and N% (neutrophil %) in the diagnosis of neonatal septicemia. 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引用次数: 0

摘要

目的:探讨SAA(血清淀粉样蛋白A)、CRP(C反应蛋白)、PCT(降钙素原)、WBC(白细胞)和N%(中性粒细胞)在新生儿败血症诊断中的应用价值。本研究是一项回顾性研究。选取2022年1月至2024年1月南华大学衡阳医学院附属长沙市中心医院新生儿科收治的173名临床诊断为败血症的患儿和66名确诊为败血症的患儿作为病例组,选取同期住院的148名新生儿黄疸患儿作为对照组。在患儿入院后24小时内采集空腹静脉血,检测血清WBC、N%、SAA、CRP和PCT水平。采用单因素方差分析和 Kruskal-Wallis H 检验比较三组儿童的一般数据和炎症指标水平。采用斯皮尔曼相关分析法对 SAA 和其他炎症指标进行相关分析。采用接收者操作特征曲线(ROC)确定不同炎症指标对确诊败血症患者和临床确诊败血症患者、临床确诊败血症患者和未感染败血症患者的诊断效果。结果显示,WBC[(16.88±5.64)×109/L]、N%[70.00(63.00,75.00)]、PCT[2.22(1.20,5.55)mg/L]、CRP[3.00(0.50,10.30)mg/L]、SAA[19.70(10.82,49.90)mg/L],WBC[(16.10±7.48)×109/L]、N%[73.50(61.50,80.93)]、PCT[5.35(0.69,20.07)mg/L]、CRP[15.52(4.98,30.50)mg/L]、SAA[43.95(14.00,175.98)mg/L]均高于对照组(11.17±3.38)×109/L、49.81(36.93,62.75)、0.20(0.07,0.99)mg/L、0.54(0.20,1.40)mg/L、5.15(3.60,8.68)mg/L,差异均有统计学意义(均P0.05)。斯皮尔曼相关分析显示,SAA 水平与白细胞、N%、PCT 和 CRP 呈正相关(rs=0.453、0.540、0.343、0.550,所有 PCI:0.809-1.000,PCI:0.818-0.904,P
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[Application of serum SAA, CRP, PCT, WBC and N% in the diagnosis of neonatal septicemia].

To explore the application value of SAA (serum amyloid A), CRP (C reactive protein), PCT (procalcitonin), WBC (white blood cell) and N% (neutrophil %) in the diagnosis of neonatal septicemia. This study was a retrospective study. 173 children with clinically diagnosed septicemia and 66 children with definitely diagnosed septicemia admitted to the Department of Neonatology, the Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China,from January 2022 to January 2024 were selected as the case group, and 148 children with neonatal jaundice who were hospitalized during the same period were selected as the control group. Fasting venous blood was collected within 24 hours after the children's admission to detect the levels of serum WBC, N%, SAA, CRP and PCT. One-way analysis of variance and Kruskal-Wallis H test were used to compare the general data and inflammatory index levels of the three groups of children. The correlation analysis between SAA and other inflammatory indicators was conducted using Spearman correlation analysis. The receiver operating characteristic (ROC) curve was used to determine the diagnostic efficacy of different inflammatory indicators for patients with definitely diagnosed septicemia and those with clinically diagnosed septicemia, and for those with clinically diagnosed septicemia and those without infection. The results showed that the levels of WBC [(16.88±5.64)×109/L], N% [70.00 (63.00, 75.00)], PCT [2.22 (1.20, 5.55) mg/L], CRP [3.00 (0.50, 10.30) mg/L], SAA [19.70 (10.82, 49.90) mg/L] in the clinically diagnosed septicemia group and WBC [(16.10±7.48)×109/L], N% [73.50 (61.50, 80.93)], PCT [5.35 (0.69, 20.07) mg/L], CRP [15.52 (4.98, 30.50) mg/L], SAA [43.95 (14.00, 175.98) mg/L] in the definitely diagnosed septicemia group were all higher than those in the control group (11.17±3.38)×109/L, 49.81 (36.93, 62.75), 0.20 (0.07, 0.99) mg/L, 0.54 (0.20, 1.40) mg/L, 5.15 (3.60, 8.68) mg/L, and the differences were all statistically significant (all P<0.05). Spearman correlation analysis showed that the level of SAA was positively correlated with WBC, N%, PCT and CRP (rs=0.453, 0.540, 0.343, 0.550, all P<0.05). ROC curve analysis showed that the area under ROC curve(AUC) of SAA for the definitely diagnosed septicemia group and the clinically diagnosed septicemia group was higher than that of other inflammatory indicators, among them, the AUC of SAA for diagnosing the definitely diagnosed neonatal septicemia group was 0.933 (95%CI: 0.809-1.000, P<0.05), with a sensitivity of 92.90% and a specificity of 99.30%. The AUC of SAA for diagnosing the clinically diagnosed septicemia group was 0.861 (95%CI: 0.818-0.904, P<0.05), with a sensitivity of 83.20% and a specificity of 81.80%. In conclusion, compared with CRP, PCT, WBC and N%, SAA has higher sensitivity and specificity for distinguishing neonatal septicemia (including definitely diagnosed septicemia and clinically diagnosed septicemia), and has certain auxiliary diagnostic value for neonatal septicemia.

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来源期刊
中华预防医学杂志
中华预防医学杂志 Medicine-Medicine (all)
CiteScore
1.20
自引率
0.00%
发文量
12678
期刊介绍: Chinese Journal of Preventive Medicine (CJPM), the successor to Chinese Health Journal , was initiated on October 1, 1953. In 1960, it was amalgamated with the Chinese Medical Journal and the Journal of Medical History and Health Care , and thereafter, was renamed as People’s Care . On November 25, 1978, the publication was denominated as Chinese Journal of Preventive Medicine . The contents of CJPM deal with a wide range of disciplines and technologies including epidemiology, environmental health, nutrition and food hygiene, occupational health, hygiene for children and adolescents, radiological health, toxicology, biostatistics, social medicine, pathogenic and epidemiological research in malignant tumor, surveillance and immunization.
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