Baiheng Zhu, Kehao Xiang, Tanghua Li, Xin Li, Fujun Shi
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引用次数: 0
摘要
乳腺癌（BC）目前在全球癌症发病率中排名第二。缺氧是乳腺癌的常见现象。在缺氧条件下，肿瘤微环境（TME）中的细胞会分泌大量细胞外囊泡（EVs），以实现细胞间的交流，并改变形成 TME 的原发性和转移性肿瘤的新陈代谢。此外，新的研究表明，缺氧会促进肿瘤治疗的抗药性。工程EV具有生物相容性高、免疫原性低、给药效率高、易于改造等特点，有望成为癌症治疗的载体。在这篇综述中，我们总结了在缺氧条件下，EVs 在原发性 TME 和 BC 远处转移中的作用机制。此外，我们还强调了工程EVs在缺氧条件下减轻BC细胞恶性表型的潜在应用。
The signature of extracellular vesicles in hypoxic breast cancer and their therapeutic engineering.
Breast cancer (BC) currently ranks second in the global cancer incidence rate. Hypoxia is a common phenomenon in BC. Under hypoxic conditions, cells in the tumor microenvironment (TME) secrete numerous extracellular vesicles (EVs) to achieve intercellular communication and alter the metabolism of primary and metastatic tumors that shape the TME. In addition, emerging studies have indicated that hypoxia can promote resistance to tumor treatment. Engineered EVs are expected to become carriers for cancer treatment due to their high biocompatibility, low immunogenicity, high drug delivery efficiency, and ease of modification. In this review, we summarize the mechanisms of EVs in the primary TME and distant metastasis of BC under hypoxic conditions. Additionally, we highlight the potential applications of engineered EVs in mitigating the malignant phenotypes of BC cells under hypoxia.
期刊介绍：
Cell Communication and Signaling (CCS) is a peer-reviewed, open-access scientific journal that focuses on cellular signaling pathways in both normal and pathological conditions. It publishes original research, reviews, and commentaries, welcoming studies that utilize molecular, morphological, biochemical, structural, and cell biology approaches. CCS also encourages interdisciplinary work and innovative models, including in silico, in vitro, and in vivo approaches, to facilitate investigations of cell signaling pathways, networks, and behavior.
Starting from January 2019, CCS is proud to announce its affiliation with the International Cell Death Society. The journal now encourages submissions covering all aspects of cell death, including apoptotic and non-apoptotic mechanisms, cell death in model systems, autophagy, clearance of dying cells, and the immunological and pathological consequences of dying cells in the tissue microenvironment.
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