营养保健品对氧化还原酶的调节:抗氧化剂多酚和肽的作用综述。

IF 5.1 1区 农林科学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Food & Function Pub Date : 2024-10-28 DOI:10.1039/d4fo03549f
Joy I Obeme-Nmom, Raliat O Abioye, Samanta S Reyes Flores, Chibuike C Udenigwe
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引用次数: 0

摘要

氧化还原酶是细胞防御氧化应激系统的重要组成部分,而氧化应激是各种疾病的常见因素。因此,了解生物活性营养保健品在调节这些酶活性方面的作用具有巨大的治疗潜力。本文全面综述了从食物中提取的生物活性营养保健品对细胞和动物模型中氧化还原酶的调节作用,重点关注多酚和多肽。具体来说,本文讨论了细胞和动物模型中超氧化物歧化酶 (SOD)、谷胱甘肽过氧化物酶 (GPx)、过氧化氢酶 (CAT)、NAPDH 氧化酶、黄嘌呤氧化酶 (XO)、髓过氧化物酶 (MPO) 和血氧饱和酶 (HO) 的调节作用。多酚在水果、蔬菜和饮料中含量丰富,具有多种抗氧化特性,包括直接清除活性氧和调节转录因子(如核因子红细胞 2 相关因子 2),从而增加氧化还原酶 SOD、HO 和 GPx 的表达。同样,各种食物蛋白质中的生物活性肽可通过调节基因表达和直接激活 CAT 酶来增强抗氧化酶的活性。在其他情况下,抗氧化反应需要下调或抑制氧化还原酶 XO、MPO 和 NAPDH 氧化酶。本文强调了生物活性营养保健品在缓解氧化应激相关疾病方面的潜力,以及它们调节氧化还原酶表达或活性的机制。此外,综述还强调了进一步研究的必要性,以发现利用营养保健品增强细胞抗氧化防御机制和改善健康状况的新治疗策略。
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Regulation of redox enzymes by nutraceuticals: a review of the roles of antioxidant polyphenols and peptides.

Redox enzymes are essential components of the cellular defence system against oxidative stress, which is a common factor in various diseases. Therefore, understanding the role of bioactive nutraceuticals in modulating the activity of these enzymes holds immense therapeutic potential. This paper provides a comprehensive review of the regulation of redox enzymes in cell and animal models by food-derived bioactive nutraceuticals, focusing on polyphenols and peptides. Specifically, this paper discusses the regulation of superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT), NAPDH oxidase, xanthine oxidase (XO), myeloperoxidase (MPO), and haem oxygenase (HO) in cell and animal models. Polyphenols, which are abundant in fruits, vegetables, and beverages, have diverse antioxidant properties, including direct scavenging of reactive oxygen species and regulation of transcription factors such as nuclear factor erythroid 2-related factor 2, which leads to the increased expression of the redoxenzymes SOD, HO, and GPx. Similarly, bioactive peptides from various food proteins can enhance antioxidative enzyme activity by regulating gene expression and directly activating the enzyme CAT. In other cases, an antioxidative response requires the downregulation or inhibition of the redox enzymes XO, MPO, and NAPDH oxidase. This paper highlights the potential of bioactive nutraceuticals in mitigating oxidative stress-related diseases and their mechanisms in modulating the redox enzyme expression or activity. Furthermore, the review highlights the need for further research to uncover new therapeutic strategies using nutraceuticals for enhancing cellular antioxidant defence mechanisms and improving health outcomes.

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来源期刊
Food & Function
Food & Function BIOCHEMISTRY & MOLECULAR BIOLOGY-FOOD SCIENCE & TECHNOLOGY
CiteScore
10.10
自引率
6.60%
发文量
957
审稿时长
1.8 months
期刊介绍: Food & Function provides a unique venue for physicists, chemists, biochemists, nutritionists and other food scientists to publish work at the interface of the chemistry, physics and biology of food. The journal focuses on food and the functions of food in relation to health.
期刊最新文献
Human milk oligosaccharides and milk fat globule membrane reduce allergic reactions in mice through the modulation of gut microbiota and metabolic functions. Back cover Regulation of redox enzymes by nutraceuticals: a review of the roles of antioxidant polyphenols and peptides. Aronia melanocarpa extract extends the lifespan and health-span of Caenorhabditis elegans via mitogen-activated protein kinase 1. Abnormal enterohepatic circulation of bile acids caused by fructooligosaccharide supplementation along with a high-fat diet.
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