枣皮中的结合酚提取物可通过减少秀丽隐杆线虫的脂质积累来缓解镉诱导的毒性。

IF 3.2 2区 农林科学 Q2 FOOD SCIENCE & TECHNOLOGY Journal of Food Science Pub Date : 2024-10-22 DOI:10.1111/1750-3841.17463
Xiaojing Li, Jinfeng Dou, Jieying Shi, Gongjian Fan, Tingting Li, Dandan Zhou, Caie Wu
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引用次数: 0

摘要

为了研究枣皮结合酚提取物(BPEs)对镉(Cd)诱导的毒性的缓解作用及其机制,研究人员测定并比较了Cd暴露组和BPEs改善组草履虫的行为缺陷、脂质积累和脂肪酸合成相关基因的表达。结果表明,BPEs能明显改善镉诱导的草履虫行为缺陷,且低剂量组(12.5 µg/mL)和高剂量组(100 µg/mL)BPEs改善组之间无显著差异。BPEs能有效改善肠道损伤和脂褐素及脂质积累。特别是,用 50 µg/mL BPEs 处理的秀丽隐杆线虫的油红 O 染色强度降低了 12.60%。BPEs 通过调节大肠杆菌 OP50 的脂质积累,明显控制了镉诱导的 C16:0、C16:1、C18:0、C18:1 和 C18:2 含量的增加。镉暴露通过上调大肠杆菌 OP50 中油酸合成相关基因的表达来诱导秀丽隐杆线虫的脂质积累。此外,BPEs 还能显著下调秀丽隐杆线虫和大肠杆菌 OP50 中脂肪酸合成相关基因的表达。这项研究可以揭示枣皮 BPEs 在缓解镉诱导毒性方面的作用机制,并为开发富含多酚的功能性食品提供理论依据。实际应用:枣皮是大枣加工的副产品,由于质地粗糙,通常被丢弃。然而,枣皮已被证实含有丰富的多酚、多糖和环磷酸腺苷。此外,我们之前的研究发现,枣皮中的结合酚提取物(BPEs)在降低脂质积累方面的效果优于游离酚提取物。本研究在前人研究的基础上,进一步探讨了枣皮结合酚提取物对缓解镉诱导毒性的作用及其机制。它可以实现大枣加工副产物的综合利用。
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Bound phenolics extracts of jujube peel relieve cadmium-induced toxicity by reducing lipid accumulation of Caenorhabditis elegans.

To investigate the effect of bound phenolics extracts (BPEs) of jujube peel on relieving cadmium (Cd)-induced toxicity and its mechanism, the behavioral deficits, lipid accumulation, and fatty acid synthesis-related gene expression in Caenorhabditis elegans in Cd exposure group and BPEs improvement groups were determined and compared. The results showed that BPEs significantly improved Cd-induced behavioral deficits in C. elegans, and no significant differences could be found in low-dose (12.5 µg/mL) and high-dose (100 µg/mL) BPEs improvement groups. The treatment of BPEs effectively improved intestinal injury and lipofuscin and lipid accumulation. Especially, oil red O staining intensity in C. elegans treated with BPEs at 50 µg/mL was reduced by 12.60%. BPEs significantly controlled the increase in content of C16:0, C16:1, C18:0, C18:1, and C18:2 induced by Cd by regulating the lipid accumulation in Escherichia coli OP50. Cd exposure induced lipid accumulation in C. elegans by upregulating oleic acid synthesis-related gene expression in E. coli OP50. Furthermore, BPEs treatment significantly downregulated the fatty acid synthesis-related gene expression in C. elegans and E. coli OP50. This research could reveal the mechanism of BPEs of jujube peel in relieving Cd-induced toxicity and provide a theoretical basis for the development of functional foods rich in polyphenols. PRACTICAL APPLICATION: Jujube peel, a by-product of jujube processing, is usually discarded due to its coarse texture. However, jujube peel has been proven to possess abundant polyphenols, polysaccharides, and cyclic adenosine phosphate. In addition, in our previous research, bound phenolics extracts (BPEs) of jujube peel were found to perform better in lowering lipid accumulation than that of free phenolics extracts. This study further investigate the effect of BPEs of jujube peel on relieving Cd-induced toxicity and its mechanism on the base of our previous research. It could realize the comprehensive utilization of by-products of jujube processing.

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来源期刊
Journal of Food Science
Journal of Food Science 工程技术-食品科技
CiteScore
7.10
自引率
2.60%
发文量
412
审稿时长
3.1 months
期刊介绍: The goal of the Journal of Food Science is to offer scientists, researchers, and other food professionals the opportunity to share knowledge of scientific advancements in the myriad disciplines affecting their work, through a respected peer-reviewed publication. The Journal of Food Science serves as an international forum for vital research and developments in food science. The range of topics covered in the journal include: -Concise Reviews and Hypotheses in Food Science -New Horizons in Food Research -Integrated Food Science -Food Chemistry -Food Engineering, Materials Science, and Nanotechnology -Food Microbiology and Safety -Sensory and Consumer Sciences -Health, Nutrition, and Food -Toxicology and Chemical Food Safety The Journal of Food Science publishes peer-reviewed articles that cover all aspects of food science, including safety and nutrition. Reviews should be 15 to 50 typewritten pages (including tables, figures, and references), should provide in-depth coverage of a narrowly defined topic, and should embody careful evaluation (weaknesses, strengths, explanation of discrepancies in results among similar studies) of all pertinent studies, so that insightful interpretations and conclusions can be presented. Hypothesis papers are especially appropriate in pioneering areas of research or important areas that are afflicted by scientific controversy.
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