精氨酸加压素可诱导镇痛效应,并抑制幸免神经损伤小鼠前扣带回皮层的锥体细胞。

IF 4.2 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM American journal of physiology. Endocrinology and metabolism Pub Date : 2024-12-01 Epub Date: 2024-10-23 DOI:10.1152/ajpendo.00361.2024
Hua-Xing Si, Xiao-Die Liu, Chao-Yi Sun, Shan-Ming Yang, Han Zhao, Xian-Xia Yan, Tao Chen, Pan Wang
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摘要

神经性疼痛(NP)是由影响躯体感觉神经系统的原发性疾病或病变引起的一种严重疾病。据报道,神经性疼痛与谷氨酸能锥体细胞活性增强和前扣带回皮层(ACC)神经振荡改变有关。精氨酸加压素(AVP)是一种神经下丘脑激素,已被证明应用于外周系统时可产生减轻疼痛的效果。然而,AVP 在中枢神经系统中诱导镇痛作用的程度和机制仍不清楚。在本研究中,我们观察到鼻内注射 AVP 可抑制神经损伤小鼠的机械痛、热痛和自发痛敏感性。同时,应用 AVP 可减少 ACC 中锥体细胞的 FOS 表达,但不能减少中间神经元的 FOS 表达。ACC的活体电生理记录进一步表明,应用AVP不仅抑制了局部场电位分析中的θ振荡,还降低了神经病理性疼痛小鼠ACC锥体细胞尖峰的发射率。综上所述,AVP通过抑制神经病理性疼痛小鼠的神经θ振荡和ACC锥体细胞的尖峰发射而诱导镇痛效应,这将为临床治疗慢性疼痛提供新的潜在无创方法。
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Arginine vasopressin induces analgesic effects and inhibits pyramidal cells in the anterior cingulate cortex in spared nerve injured mice.

Neuropathic pain (NP) is a severe disease caused by a primary disease or lesion affecting the somatosensory nervous system. It is reported that NP is related to the increased activity of glutamatergic pyramidal cells and changed neural oscillations in the anterior cingulate cortex (ACC). Arginine vasopressin (AVP), a neurohypophyseal hormone, has been shown to cause pain-alleviating effects when applied to the peripheral system. However, the extent to which, and the mechanisms by which, AVP induces analgesic effects in the central nervous system remains unclear. In the present study, we observed that intranasal delivery of AVP inhibited mechanical pain, thermal pain, and spontaneous pain sensitivity in mice with spared nerve injury. Meanwhile, AVP application exclusively reduced the FOS expression in the pyramidal cells but not interneurons in the ACC. In vivo electrophysiological recording of the ACC further showed that AVP application not only inhibited the theta oscillation in local field potential analysis but also reduced the firing rate of spikes of pyramidal cells in the ACC in neuropathic pain mice. In summary, AVP induces analgesic effects by inhibiting neural theta oscillations and the spiking of pyramidal cells of the ACC in mice with neuropathic pain, which should provide new potential noninvasive methods for clinical treatment of chronic pain.NEW & NOTEWORTHY Following intranasal administration of arginine vasopressin (AVP), the pain thresholds for mechanical and thermal nociception significantly increased in the spared nerve injury (SNI) group; exogenous intranasal delivery of AVP improved the physical coordination of SNI mice, resulting in an analgesic effect; AVP treatment significantly reduced the increased firing rate of PYRACC of the SNI group; AVP treatment significantly inhibited the elevated theta oscillation in the anterior cingulate cortex (ACC) in SNI mice.

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来源期刊
CiteScore
9.80
自引率
0.00%
发文量
98
审稿时长
1 months
期刊介绍: The American Journal of Physiology-Endocrinology and Metabolism publishes original, mechanistic studies on the physiology of endocrine and metabolic systems. Physiological, cellular, and molecular studies in whole animals or humans will be considered. Specific themes include, but are not limited to, mechanisms of hormone and growth factor action; hormonal and nutritional regulation of metabolism, inflammation, microbiome and energy balance; integrative organ cross talk; paracrine and autocrine control of endocrine cells; function and activation of hormone receptors; endocrine or metabolic control of channels, transporters, and membrane function; temporal analysis of hormone secretion and metabolism; and mathematical/kinetic modeling of metabolism. Novel molecular, immunological, or biophysical studies of hormone action are also welcome.
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