研究有机和非有机纳米粒子在胃癌治疗中的潜在应用:循证综述。

Q3 Veterinary Archives of Razi Institute Pub Date : 2024-04-30 eCollection Date: 2024-04-01 DOI:10.32592/ARI.2024.79.2.264
N Moradifar, A Moayyedkazemi, H R Mohammadi, S Ahmadi Somaghian, Y Raziani
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引用次数: 0

摘要

胃癌被认为是一个主要的健康问题,是全球第六大高发癌症和癌症相关死亡的第二大原因。本调查旨在系统回顾所有有机和无机纳米粒子(NPs)在体外、体内和临床试验中的抗胃癌效果。调查遵循了 PRISMA 准则,并将结果记录在 CAMARADES-NC3Rs 临床前系统综述和 Meta 分析设施数据库中。我们在 Scopus、Web of Science、EMBASE、PubMed 和 Google Scholar 等多个英文数据库中进行了详细检索,没有指定发表时间,以获取有关纳米粒子抗胃癌特性的论文。搜索过程中使用了以下术语:"纳米粒子"、"胃癌"、"抗胃癌"、"金属纳米粒子"、"有机纳米粒子"、"无机纳米粒子"、"体外"、"临床 "和 "体内"。截至 2023 年,在 11,189 篇论文中,有 31 篇符合本系统综述的纳入标准,包括 19 篇(45.5%)体外论文、3 篇(13.6%)体内论文、3 篇(13.6%)临床试验论文和 6 篇(27.3%)体外/体内论文。研究发现,使用最广泛的纳米粒子是有机纳米粒子,如聚乳酸和聚乳酸-共聚乙醇酸(16,80.0%),其次是无机纳米粒子,如银纳米粒子(13,41.9.0%)。本综述研究强调了多种有机和无机纳米粒子通过诱导细胞凋亡、基因治疗和药物递送等机制的活性,具有很高的抗胃癌潜力。然而,还需要进一步的研究,特别是在临床环境中的研究,以确认其抗胃癌效果和准确机制。
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Investigating the potential application of organic and non-organic nanoparticles for gastric cancer treatment: An evidence-based review.

Gastric cancer, which is considered a major health concern, is the sixth most frequent cancer and the second leading cause of cancer-related mortality across the globe. The present survey aimed to systematically review the anti-gastric cancer effect of all organic and inorganic nanoparticles (NPs) in in vitro, in vivo, and clinical trials. The investigation followed the PRISMA guidelines, and the findings were recorded in the CAMARADES-NC3Rs Preclinical Systematic Review and Meta-Analysis Facility database. A detailed search was conducted on various English databases, such as Scopus, Web of Science, EMBASE, PubMed, and Google Scholar, with no specified publication time frame to obtain papers regarding the anti-gastric cancer properties of nanoparticles. The search process was performed using the following terms "Nanoparticles," "Gastric cancer," "Anti-gastric cancer," "Metal nanoparticles," "Organic nanoparticles," "Inorganic nanoparticles, "in vitro," "Clinical," and "in vivo,". Out of 11,189 papers, 31 articles, including 19 (45.5%) in vitro, 3 (13.6%) in vivo, 3 (13.6%) clinical trials, and 6 (27.3%) in vitro/in vivo, up to 2023, met the inclusion criteria for discussion in this systematic review. The most widely used NPs were found to be organic nanoparticles, such as polylactic acid and poly lactic-co-glycolic acid (16, 80.0%), followed by inorganic nanoparticles, such as silver NPs (13, 41.9.0%). This review study highlighted the high anti-gastric cancer potential of a wide range of organic and non-organic NPs through their activity via some mechanisms, such as the induction of apoptosis, gene therapy, and drug delivery. Nonetheless, further studies, especially in clinical settings, are needed to confirm their anti-gastric effects and accurate mechanisms.

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来源期刊
Archives of Razi Institute
Archives of Razi Institute Veterinary-Veterinary (all)
CiteScore
1.50
自引率
0.00%
发文量
108
审稿时长
12 weeks
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