类别界限以类似于地点细胞的方式调节记忆。

IF 8.1 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Current Biology Pub Date : 2024-10-25 DOI:10.1016/j.cub.2024.09.083
Stephanie Theves, Theo A J Schäfer, Volker Reisner, William de Cothi, Caswell Barry
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引用次数: 0

摘要

概念描述了同类实例之间的关系,从而能够对新信息进行分类和解释。类别边界一直被认为是概念表征的决定性特征,可以指导分类推断3 ,fMRI 证据显示海马体中存在类别边界信号4,5 。4,8,9,10,11 物理边界锚定了空间表征,边界的移动影响了位置和网格场12,13,14,15,16 以及人类的空间记忆17,18,19。这些位置细胞的反应很可能是由边界向量细胞驱动的,它们对特定分配中心距离和方向上的边界做出反应20,21,22,23,其神经相关性已在子网膜和内侧皮层中得到确认20,24,25。我们假设,类别边界的移动也会导致类似的记忆适应模式。我们的研究结果表明,在类别边界发生变化后,参与者对类别示例的记忆会沿着变化的维度发生扭曲,这反映了位置场的变形。我们证明,与其他几何解释相比,边界矢量细胞的位置细胞点燃模型最能解释这些变形。我们的研究强调了类别边界在人类认知中的作用,并在海马体关于边界的编码特性与人类概念表征之间建立了一种新的互补联系,从而在空间和概念领域架起了一座桥梁。
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Category boundaries modulate memory in a place-cell-like manner.

Concepts describe how instances of the same kind are related, enabling the categorization and interpretation of new information.1,2 How concepts are represented is a longstanding question. Category boundaries have been considered defining features of concept representations, which can guide categorical inference,3 with fMRI evidence showing category-boundary signals in the hippocampus.4,5 The underlying neural mechanism remains unclear. The hippocampal-entorhinal system, known for its spatially tuned neurons that form cognitive maps of space,6,7 may support conceptual knowledge formation, with place cells encoding locations in conceptual space.4,8,9,10,11 Physical boundaries anchor spatial representations and boundary shifts affect place and grid fields,12,13,14,15,16 as well as human spatial memory,17,18,19 along manipulated dimensions. These place cell responses are likely driven by boundary vector cells, which respond to boundaries at specific allocentric distances and directions,20,21,22,23 the neural correlates of which have been identified in the subiculum and entorhinal cortex20,24,25. We hypothesize similar patterns of memory adaptations in response to shifting category boundaries. Our findings show that after category boundary shifts, participants' memory for category exemplars distorts along the changed dimension, mirroring place field deformations. We demonstrate that the boundary vector cell model of place cell firing best accounts for these distortions compared with alternative geometric explanations. Our study highlights a role of category boundaries in human cognition and establishes a new complementary link between hippocampal coding properties with respect to boundaries and human concept representation, bridging spatial and conceptual domains.

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来源期刊
Current Biology
Current Biology 生物-生化与分子生物学
CiteScore
11.80
自引率
2.20%
发文量
869
审稿时长
46 days
期刊介绍: Current Biology is a comprehensive journal that showcases original research in various disciplines of biology. It provides a platform for scientists to disseminate their groundbreaking findings and promotes interdisciplinary communication. The journal publishes articles of general interest, encompassing diverse fields of biology. Moreover, it offers accessible editorial pieces that are specifically designed to enlighten non-specialist readers.
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