Amirhosein Baradaran Najar, Guillaume Gilbert, Elige Karam, Anton Volniansky, Audrey Fohlen, Maxime Barat, Emmanuel Montagnon, Hélène Castel, Jeanne-Marie Giard, Bich N Nguyen, Guy Cloutier, An Tang, Elijah Van Houten
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Applying it to focal liver lesions extends its capabilities.</p><p><strong>Purpose: </strong>To assess the viscoelastic parameters of focal liver lesions measured by iMRE and compare its diagnostic performance with extrinsic MRE (eMRE) for differentiating malignant and benign lesions.</p><p><strong>Study type: </strong>Prospective.</p><p><strong>Population: </strong>A total of 55 participants underwent MRI with research MRE sequences; 32 participants with 17 malignant and 15 benign lesions underwent both iMRE and eMRE. FIELD STRENGTH/SEQUENCE: iMRE at ~1 Hz heart rate used a 3 T scanner with a modified four-dimensional (4D)-quantitative flow gradient-echo phase contrast and low-velocity encoding cardiac-triggered technique. eMRE employed a gradient-echo sequence at 30, 40, and 60 Hz.</p><p><strong>Assessment: </strong>Liver displacements were measured using 4D-phase contrast and reconstructed via a nonlinear inversion algorithm to determine shear stiffness (SS) and damping ratio (DR). iMRE parameters were normalized to the corresponding values from the spleen. Lesions were manually segmented, and image quality was reviewed.</p><p><strong>Statistical tests: </strong>Kruskal-Wallis, Mann-Whitney, Dunn's test, and areas under receiver operating characteristic curves (AUC) were assessed.</p><p><strong>Results: </strong>SS was significantly higher in malignant than benign lesions with iMRE at 1 Hz (3.69 ± 1.31 vs. 1.63 ± 0.45) and eMRE at 30 Hz (3.76 ± 1.12 vs. 2.60 ± 1.26 kPa), 40 Hz (3.76 ± 1.12 vs. 2.60 ± 1.26 kPa), and 60 Hz (7.32 ± 2.87 vs. 2.48 ± 1.12 kPa). DR was also significantly higher in malignant than benign lesions at 40 Hz (0.36 ± 0.11 vs. 0.21 ± 0.01) and 60 Hz (0.89 ± 0.86 vs. 0.22 ± 0.09). The AUC were 0.86 for iMRE SS, 0.87-0.98 for eMRE SS, 0.47 for iMRE DR, and 0.62-0.86 for eMRE DR.</p><p><strong>Data conclusion: </strong>Cardiac-activated iMRE can characterize liver lesions and differentiate malignant from benign lesions through normalized SS maps.</p><p><strong>Level of evidence: </strong>2 TECHNICAL EFFICACY: Stage 2.</p>","PeriodicalId":3,"journal":{"name":"ACS Applied Electronic Materials","volume":null,"pages":null},"PeriodicalIF":4.3000,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"MR Elastography for Classification of Focal Liver Lesions Using Viscoelastic Parameters: A Pilot Study Based on Intrinsic and Extrinsic Activations.\",\"authors\":\"Amirhosein Baradaran Najar, Guillaume Gilbert, Elige Karam, Anton Volniansky, Audrey Fohlen, Maxime Barat, Emmanuel Montagnon, Hélène Castel, Jeanne-Marie Giard, Bich N Nguyen, Guy Cloutier, An Tang, Elijah Van Houten\",\"doi\":\"10.1002/jmri.29633\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Intrinsic activation MR elastography (iMRE) uses cardiovascular pulsations to assess tissue viscoelastic properties. 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Lesions were manually segmented, and image quality was reviewed.</p><p><strong>Statistical tests: </strong>Kruskal-Wallis, Mann-Whitney, Dunn's test, and areas under receiver operating characteristic curves (AUC) were assessed.</p><p><strong>Results: </strong>SS was significantly higher in malignant than benign lesions with iMRE at 1 Hz (3.69 ± 1.31 vs. 1.63 ± 0.45) and eMRE at 30 Hz (3.76 ± 1.12 vs. 2.60 ± 1.26 kPa), 40 Hz (3.76 ± 1.12 vs. 2.60 ± 1.26 kPa), and 60 Hz (7.32 ± 2.87 vs. 2.48 ± 1.12 kPa). DR was also significantly higher in malignant than benign lesions at 40 Hz (0.36 ± 0.11 vs. 0.21 ± 0.01) and 60 Hz (0.89 ± 0.86 vs. 0.22 ± 0.09). 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引用次数: 0
摘要
背景：内在活化磁共振弹性成像（iMRE）利用心血管搏动来评估组织的粘弹性。目的：评估 iMRE 测量的肝脏病灶粘弹性参数，并比较其与外源性磁共振弹性成像（eMRE）在区分恶性和良性病灶方面的诊断性能：研究类型：前瞻性：共有55名参与者接受了研究MRE序列的磁共振成像检查；32名参与者同时接受了iMRE和eMRE检查，其中17例为恶性病变，15例为良性病变。场强/序列：心率约为 1 Hz 的 iMRE 使用 3 T 扫描仪，采用改良的四维（4D）定量血流梯度回波相位对比和低速编码心脏触发技术；eMRE 采用 30、40 和 60 Hz 的梯度回波序列：评估：使用四维相位对比测量肝脏位移，并通过非线性反转算法进行重建，以确定剪切硬度（SS）和阻尼比（DR）。对病变进行人工分割，并审查图像质量：统计测试：Kruskal-Wallis、Mann-Whitney、Dunn's 检验和接收器操作特征曲线下面积（AUC）：在 1 Hz iMRE（3.69 ± 1.31 vs. 1.63 ± 0.45）和 30 Hz eMRE（3.76 ± 1.12 vs. 2.60 ± 1.26 kPa）、40 Hz（3.76 ± 1.12 vs. 2.60 ± 1.26 kPa）和 60 Hz（7.32 ± 2.87 vs. 2.48 ± 1.12 kPa）下，恶性病变的 SS 明显高于良性病变。在 40 赫兹（0.36 ± 0.11 vs. 0.21 ± 0.01）和 60 赫兹（0.89 ± 0.86 vs. 0.22 ± 0.09）下，恶性病变的 DR 也明显高于良性病变。iMRE SS 的 AUC 为 0.86，eMRE SS 为 0.87-0.98，iMRE DR 为 0.47，eMRE DR 为 0.62-0.86：数据结论：心脏激活的 iMRE 可描述肝脏病变的特征，并通过归一化 SS 地图区分恶性和良性病变。
MR Elastography for Classification of Focal Liver Lesions Using Viscoelastic Parameters: A Pilot Study Based on Intrinsic and Extrinsic Activations.
Background: Intrinsic activation MR elastography (iMRE) uses cardiovascular pulsations to assess tissue viscoelastic properties. Applying it to focal liver lesions extends its capabilities.
Purpose: To assess the viscoelastic parameters of focal liver lesions measured by iMRE and compare its diagnostic performance with extrinsic MRE (eMRE) for differentiating malignant and benign lesions.
Study type: Prospective.
Population: A total of 55 participants underwent MRI with research MRE sequences; 32 participants with 17 malignant and 15 benign lesions underwent both iMRE and eMRE. FIELD STRENGTH/SEQUENCE: iMRE at ~1 Hz heart rate used a 3 T scanner with a modified four-dimensional (4D)-quantitative flow gradient-echo phase contrast and low-velocity encoding cardiac-triggered technique. eMRE employed a gradient-echo sequence at 30, 40, and 60 Hz.
Assessment: Liver displacements were measured using 4D-phase contrast and reconstructed via a nonlinear inversion algorithm to determine shear stiffness (SS) and damping ratio (DR). iMRE parameters were normalized to the corresponding values from the spleen. Lesions were manually segmented, and image quality was reviewed.
Statistical tests: Kruskal-Wallis, Mann-Whitney, Dunn's test, and areas under receiver operating characteristic curves (AUC) were assessed.
Results: SS was significantly higher in malignant than benign lesions with iMRE at 1 Hz (3.69 ± 1.31 vs. 1.63 ± 0.45) and eMRE at 30 Hz (3.76 ± 1.12 vs. 2.60 ± 1.26 kPa), 40 Hz (3.76 ± 1.12 vs. 2.60 ± 1.26 kPa), and 60 Hz (7.32 ± 2.87 vs. 2.48 ± 1.12 kPa). DR was also significantly higher in malignant than benign lesions at 40 Hz (0.36 ± 0.11 vs. 0.21 ± 0.01) and 60 Hz (0.89 ± 0.86 vs. 0.22 ± 0.09). The AUC were 0.86 for iMRE SS, 0.87-0.98 for eMRE SS, 0.47 for iMRE DR, and 0.62-0.86 for eMRE DR.
Data conclusion: Cardiac-activated iMRE can characterize liver lesions and differentiate malignant from benign lesions through normalized SS maps.
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