再次出现的钱迪普拉水泡病毒:全球健康的隐忧。

Q2 Medicine VirusDisease Pub Date : 2024-09-01 Epub Date: 2024-10-03 DOI:10.1007/s13337-024-00896-5
Abhishek Padhi, Ashwini Agarwal, Praggya Mishra, Ekta Gupta, Swatantra Kumar, C D S Katoch, Shailendra K Saxena
{"title":"再次出现的钱迪普拉水泡病毒:全球健康的隐忧。","authors":"Abhishek Padhi, Ashwini Agarwal, Praggya Mishra, Ekta Gupta, Swatantra Kumar, C D S Katoch, Shailendra K Saxena","doi":"10.1007/s13337-024-00896-5","DOIUrl":null,"url":null,"abstract":"<p><p><i>Chandipura vesiculovirus</i> (CHPV) is an emerging neurotropic virus primarily affecting children and causing acute encephalitis syndrome (AES) in India. The virus, transmitted mainly by sand flies, has led to multiple outbreaks with high mortality rates, particularly in rural and resource-limited settings. CHPV infection is characterized by rapid disease progression, with symptoms ranging from fever and seizures to coma and death, often within 24 to 48 h of onset. The current management of CHPV is limited to supportive care due to the lack of specific antiviral therapies. Diagnosis relies on laboratory methods such as RT-PCR, serology, and immunofluorescence, though these face challenges due to the rapid progression of the disease and the need for timely sample collection and analysis. Prevention strategies are focused on vector control through insecticide use and public health interventions, including community education and early detection programs. Despite some progress in understanding CHPV, significant research gaps remain, particularly in developing effective antiviral treatments and vaccines, understanding transmission dynamics, and improving diagnostic capabilities. The potential for the virus to spread globally due to factors like climate change and increased human movement underscores the need for international collaboration in surveillance and response efforts. Strengthening public health infrastructure, enhancing vector control measures, and fostering global partnerships are crucial steps toward mitigating the impact of CHPV and preventing future outbreaks. Continued research and proactive public health strategies are essential to protect vulnerable populations and control the spread of this potentially deadly virus.</p>","PeriodicalId":23708,"journal":{"name":"VirusDisease","volume":"35 3","pages":"385-399"},"PeriodicalIF":0.0000,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11502618/pdf/","citationCount":"0","resultStr":"{\"title\":\"Re-emerging <i>Chandipura</i> <i>vesiculovirus</i>: A cause of concern for global health.\",\"authors\":\"Abhishek Padhi, Ashwini Agarwal, Praggya Mishra, Ekta Gupta, Swatantra Kumar, C D S Katoch, Shailendra K Saxena\",\"doi\":\"10.1007/s13337-024-00896-5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><i>Chandipura vesiculovirus</i> (CHPV) is an emerging neurotropic virus primarily affecting children and causing acute encephalitis syndrome (AES) in India. The virus, transmitted mainly by sand flies, has led to multiple outbreaks with high mortality rates, particularly in rural and resource-limited settings. CHPV infection is characterized by rapid disease progression, with symptoms ranging from fever and seizures to coma and death, often within 24 to 48 h of onset. The current management of CHPV is limited to supportive care due to the lack of specific antiviral therapies. Diagnosis relies on laboratory methods such as RT-PCR, serology, and immunofluorescence, though these face challenges due to the rapid progression of the disease and the need for timely sample collection and analysis. Prevention strategies are focused on vector control through insecticide use and public health interventions, including community education and early detection programs. Despite some progress in understanding CHPV, significant research gaps remain, particularly in developing effective antiviral treatments and vaccines, understanding transmission dynamics, and improving diagnostic capabilities. The potential for the virus to spread globally due to factors like climate change and increased human movement underscores the need for international collaboration in surveillance and response efforts. Strengthening public health infrastructure, enhancing vector control measures, and fostering global partnerships are crucial steps toward mitigating the impact of CHPV and preventing future outbreaks. Continued research and proactive public health strategies are essential to protect vulnerable populations and control the spread of this potentially deadly virus.</p>\",\"PeriodicalId\":23708,\"journal\":{\"name\":\"VirusDisease\",\"volume\":\"35 3\",\"pages\":\"385-399\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11502618/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"VirusDisease\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/s13337-024-00896-5\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/10/3 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"VirusDisease","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s13337-024-00896-5","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/10/3 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0

摘要

昌迪普拉囊状病毒(Chandipura vesiculovirus,CHPV)是一种新出现的神经性病毒,在印度主要影响儿童并导致急性脑炎综合症(AES)。该病毒主要通过沙蝇传播,已导致多次爆发,死亡率很高,尤其是在农村和资源有限的环境中。CHPV 感染的特点是疾病进展迅速,症状从发烧、抽搐到昏迷和死亡,通常在发病后 24 至 48 小时内出现。由于缺乏特异性抗病毒疗法,目前对 CHPV 的治疗仅限于支持性护理。诊断主要依靠 RT-PCR、血清学和免疫荧光等实验室方法,但由于病情发展迅速,且需要及时采集和分析样本,这些方法面临着挑战。预防策略的重点是通过使用杀虫剂控制病媒,并采取公共卫生干预措施,包括社区教育和早期检测计划。尽管在了解 CHPV 方面取得了一些进展,但研究工作仍存在很大差距,特别是在开发有效的抗病毒治疗方法和疫苗、了解传播动态和提高诊断能力方面。由于气候变化和人员流动增加等因素,该病毒有可能在全球范围内传播,这凸显了在监测和应对工作中开展国际合作的必要性。加强公共卫生基础设施、强化病媒控制措施和促进全球合作伙伴关系是减轻 CHPV 影响和预防未来疫情爆发的关键步骤。持续研究和积极主动的公共卫生战略对于保护易感人群和控制这种潜在致命病毒的传播至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Re-emerging Chandipura vesiculovirus: A cause of concern for global health.

Chandipura vesiculovirus (CHPV) is an emerging neurotropic virus primarily affecting children and causing acute encephalitis syndrome (AES) in India. The virus, transmitted mainly by sand flies, has led to multiple outbreaks with high mortality rates, particularly in rural and resource-limited settings. CHPV infection is characterized by rapid disease progression, with symptoms ranging from fever and seizures to coma and death, often within 24 to 48 h of onset. The current management of CHPV is limited to supportive care due to the lack of specific antiviral therapies. Diagnosis relies on laboratory methods such as RT-PCR, serology, and immunofluorescence, though these face challenges due to the rapid progression of the disease and the need for timely sample collection and analysis. Prevention strategies are focused on vector control through insecticide use and public health interventions, including community education and early detection programs. Despite some progress in understanding CHPV, significant research gaps remain, particularly in developing effective antiviral treatments and vaccines, understanding transmission dynamics, and improving diagnostic capabilities. The potential for the virus to spread globally due to factors like climate change and increased human movement underscores the need for international collaboration in surveillance and response efforts. Strengthening public health infrastructure, enhancing vector control measures, and fostering global partnerships are crucial steps toward mitigating the impact of CHPV and preventing future outbreaks. Continued research and proactive public health strategies are essential to protect vulnerable populations and control the spread of this potentially deadly virus.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
VirusDisease
VirusDisease Medicine-Infectious Diseases
CiteScore
7.00
自引率
0.00%
发文量
46
期刊介绍: VirusDisease, formerly known as ''Indian Journal of Virology'', publishes original research on all aspects of viruses infecting animal, human, plant, fish and other living organisms.
期刊最新文献
A sensitive batch detection of banana bunchy top virus using SYBR® Green real-time PCR. Burden of rotavirus and adenovirus gastroenteritis in children and adults hospitalized in two geo-climatically different provinces of Sri Lanka. Comparison of SARS-CoV-2 RNA detection in different types of clinical specimens among suspected COVID-19 patients in Addis Ababa, Ethiopia. Exploring immunogenic CD8 + T-cell epitopes for peptide-based vaccine development against evolving SARS-CoV-2 variants: An immunoinformatics approach. Identification of nine putative novel members of plant-infecting alphaflexiviruses in public domain plant transcriptomes.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1