肥胖是导致小儿 COVID-19 严重程度的风险因素:可能的机制--叙述性综述。

IF 2 4区 医学 Q2 PEDIATRICS Children-Basel Pub Date : 2024-09-30 DOI:10.3390/children11101203
Dana Elena Mîndru, Elena Țarcă, Heidrun Adumitrăchioaiei, Dana Teodora Anton-Păduraru, Violeta Ștreangă, Otilia Elena Frăsinariu, Alexandra Sidoreac, Cristina Stoica, Valentin Bernic, Alina-Costina Luca
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引用次数: 0

摘要

肥胖症是当前的流行病,在儿童和青少年中的发病率上升令人担忧,对不久将来的预测也令人担忧。本文旨在提请人们注意,在病毒感染的情况下,过多的脂肪组织会在短期内对儿科患者造成影响,因为病毒感染的病程通常很严重,甚至危及生命。COVID-19 大流行就是这些声明的基础,它为研究肥胖在病毒感染时的反响打开了大门。自 2003 年发现 SARS-CoV-1 以来,人们对冠状病毒的研究兴趣稳步上升,并在大流行期间达到顶峰。因此,肥胖已被确定为 COVID-19 感染的一个独立风险因素,并与儿科患者出现严重后果的风险增加有关。我们试图确定肥胖在病毒感染时导致不利演变的主要机制,重点是由 SARS-CoV-2 引起的疾病,希望未来的研究能进一步阐明这一方面,从而能够对肥胖的病毒感染患者进行及时有效的干预,因为他们的临床进展可能是有利的。
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Obesity as a Risk Factor for the Severity of COVID-19 in Pediatric Patients: Possible Mechanisms-A Narrative Review.

Obesity, the current pandemic, is associated with alarming rises among children and adolescents, and the forecasts for the near future are worrying. The present paper aims to draw attention to the short-term effects of the excess adipose tissue in the presence of a viral infection, which can be life-threatening for pediatric patients, given that the course of viral infections is often severe, if not critical. The COVID-19 pandemic has been the basis of these statements, which opened the door to the study of the repercussions of obesity in the presence of a viral infection. Since 2003, with the discovery of SARS-CoV-1, interest in the study of coronaviruses has steadily increased, with a peak during the pandemic. Thus, obesity has been identified as an independent risk factor for COVID-19 infection and is correlated with a heightened risk of severe outcomes in pediatric patients. We sought to determine the main mechanisms through which obesity is responsible for the unfavorable evolution in the presence of a viral infection, with emphasis on the disease caused by SARS-CoV-2, in the hope that future studies will further elucidate this aspect, enabling prompt and effective intervention in obese patients with viral infections, whose clinical progression is likely to be favorable.

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来源期刊
Children-Basel
Children-Basel PEDIATRICS-
CiteScore
2.70
自引率
16.70%
发文量
1735
审稿时长
6 weeks
期刊介绍: Children is an international, open access journal dedicated to a streamlined, yet scientifically rigorous, dissemination of peer-reviewed science related to childhood health and disease in developed and developing countries. The publication focuses on sharing clinical, epidemiological and translational science relevant to children’s health. Moreover, the primary goals of the publication are to highlight under‑represented pediatric disciplines, to emphasize interdisciplinary research and to disseminate advances in knowledge in global child health. In addition to original research, the journal publishes expert editorials and commentaries, clinical case reports, and insightful communications reflecting the latest developments in pediatric medicine. By publishing meritorious articles as soon as the editorial review process is completed, rather than at predefined intervals, Children also permits rapid open access sharing of new information, allowing us to reach the broadest audience in the most expedient fashion.
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