无症状孕产妇疾病伴有症状性新生儿表现:一个简短的病例系列。

IF 2 4区 医学 Q2 PEDIATRICS Children-Basel Pub Date : 2024-10-03 DOI:10.3390/children11101214
Adriana Mihaela Dan, Diana Iulia Vasilescu, Sorin Liviu Vasilescu, Vlad Dima, Monica Mihaela Cîrstoiu
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引用次数: 0

摘要

有资料表明,母体疾病或治疗会影响新生儿出生时的临床状态。如果没有产前病史,或者母亲的疾病征兆或症状在孕期或产后首次显现,则可能会对新生儿造成错误的影响:本研究的目的是强调产前保健对母亲和新生儿的重要性,因为在孕期缺乏母亲的体征和症状并不能排除潜在的严重新生儿疾病:我们介绍了三例孕妇产下病情严重的早产新生儿并需要入住新生儿重症监护室(NICU)的病例。这些母亲在怀孕期间没有任何症状,也不知道自己患有亚临床疾病。新生儿的并发症最初被认为是早产或感染的后果,但后来发现其中两个病例患有短暂的自身免疫性疾病(重症肌无力和甲状腺功能亢进),第三个病例患有严重的血栓性疾病:结果:新生儿的诊断先于母体的诊断,有助于确定母体的病变;给予了适当的治疗,取得了良好的短期和长期疗效:结论:整个孕期的产前检查和检验是发现亚临床疾病或易感性的好机会。由于新生儿通常会出现非特异性体征,因此应积累经验并注意区分病因。我们的论文采用了与通常医疗诊断路径相反的方法:从婴儿到母亲,而不是从母亲到婴儿,证明了跨专业合作可以双向发挥作用。
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Asymptomatic Maternal Diseases Presenting with Symptomatic Neonatal Manifestations: A Short Case Series.

It is documented that maternal diseases or treatments influence a newborn's clinical status at birth. If a prenatal medical history is not available, or if signs or symptoms of a mother's disease are revealed for the first time during pregnancy or postpartum, their effects on the newborn may be misattributed.

Objective: The objective of this study is to emphasize the paramount importance of prenatal care, for both mothers and newborns, as a lack of maternal signs and symptoms during pregnancy does not exclude a potential severe neonatal condition.

Materials and methods: We present a series of three cases of pregnant women who gave birth to very sick preterm newborns that required admission to the Neonatal Intensive Care Unit (NICU). The mothers were asymptomatic during pregnancy and unaware of their subclinical disease. The newborns' complications, considered initially as consequences of prematurity or infection, subsequently revealed transient autoimmune disease in two of the cases (myasthenia gravis and hyperthyroidism) and a severe form of thrombophilia in the third case.

Results: The newborns' diagnosis preceded maternal diagnosis and contributed to the identification of the maternal pathology; adequate treatment was prescribed, with favorable short- and long-term outcomes.

Conclusions: Prenatal exams and investigations throughout pregnancy are a good opportunity to detect subclinical diseases or predispositions. As newborns usually develop non-specific signs, one should have experience and pay attention to differentiating among etiologies. Our paper takes a reversed approach to the usual medical diagnosis pathway: from infant to mother instead of from mother to infant, proving that inter-specialty collaboration can work bi-directionally.

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来源期刊
Children-Basel
Children-Basel PEDIATRICS-
CiteScore
2.70
自引率
16.70%
发文量
1735
审稿时长
6 weeks
期刊介绍: Children is an international, open access journal dedicated to a streamlined, yet scientifically rigorous, dissemination of peer-reviewed science related to childhood health and disease in developed and developing countries. The publication focuses on sharing clinical, epidemiological and translational science relevant to children’s health. Moreover, the primary goals of the publication are to highlight under‑represented pediatric disciplines, to emphasize interdisciplinary research and to disseminate advances in knowledge in global child health. In addition to original research, the journal publishes expert editorials and commentaries, clinical case reports, and insightful communications reflecting the latest developments in pediatric medicine. By publishing meritorious articles as soon as the editorial review process is completed, rather than at predefined intervals, Children also permits rapid open access sharing of new information, allowing us to reach the broadest audience in the most expedient fashion.
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