发育性语言障碍儿童反馈处理的差异神经机制:对中额Theta连接性的研究

IF 2 4区 医学 Q2 PEDIATRICS Children-Basel Pub Date : 2024-10-08 DOI:10.3390/children11101221
Asiya Gul, Annika L Schafer, Yael Arbel
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引用次数: 0

摘要

背景/目的:以往的研究表明,患有发育性语言障碍(DLD)的儿童在从反馈中学习方面面临挑战,从而导致他们的表现和学习效果不尽如人意。反馈处理是发展中的一项关键执行功能,涉及对目标导向行为至关重要的认知过程。本研究研究了学龄期 DLD 儿童与发育正常(TD)儿童相比,其反馈处理的神经机制,重点研究了作为认知控制和错误监测指标的额中叶 theta 波段(4-8 Hz)振荡:我们测量了患有和未患有 DLD 的儿童(n = 33,8-13 岁)在中额叶(FCz)、外侧前额叶(F3/F4)和外侧中央(C3/C4)部位的中额θ试间相干性(ITC)和部位间相干性(ISC)、在两个时间窗(200-400 毫秒,与反馈相关负性或 FRN 相关;400-600 毫秒,与 P3a 相关)内,对威斯康星卡片分类测试 (WCST) 中提供的反馈做出反应。)结果显示患有和未患有 DLD 的儿童在对负反馈做出反应时表现出中额θ振荡升高,随后在 FRN 时间窗内成功地调整了行为。P3a 时间窗的激活只出现在 TD 组。在与有效处理负面反馈相关的部位间一致性(ISC)方面也发现了组间差异。在TD组,负反馈的有效处理与中额部和右侧感觉运动区之间的高连通性有关,而在DLD组,负反馈的有效处理与中额部和左侧感觉运动部位之间的高连通性有关:DLD儿童的ISC模式差异可能表明他们采用了替代性或补偿性神经策略,这可能是由于右侧感觉运动参与不典型所致。
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Differential Neural Mechanisms of Feedback Processing in Children with Developmental Language Disorder: An Examination of Midfrontal Theta Connectivity.

Background/objectives: Previous research indicates that children with Developmental Language Disorder (DLD) face challenges learning from feedback, resulting in suboptimal performance and learning outcomes. Feedback processing, a key developing executive function, involves cognitive processes critical for goal-directed behavior. This study examined the neural mechanisms underlying feedback processing in school-age children with DLD compared to typically developing (TD) peers, focusing on midfrontal theta band (4-8 Hz) oscillations as an index of cognitive control and error monitoring.

Methods: We measured midfrontal theta inter-trial coherence (ITC) and inter-site coherence (ISC) at midfrontal (FCz), lateral prefrontal (F3/F4), and lateral central (C3/C4) sites in children with and without DLD (n = 33, age 8-13 years) in response to feedback provision within a Wisconsin Card Sorting Test (WCST) in two time windows (200-400 ms, which is associated with the Feedback-Related Negativity, or FRN, and 400-600 ms, which is associated with the P3a).

Results: Children with and without DLD showed elevated midfrontal theta oscillations in response to negative feedback that was followed by successful behavioral adjustments in the FRN time window. Activation in the P3a time window was only found in the TD group. Group differences were also noted in the inter-site coherence (ISC) associated with the effective processing of negative feedback. While in the TD group, effective processing of negative feedback was linked to high connectivity between midfrontal and right sensorimotor regions, in the DLD group, effective processing of negative feedback was associated with high connectivity between midfrontal and left sensorimotor sites.

Conclusions: Differential ISC patterns in children with DLD may indicate that they employ alternative or compensatory neural strategies, possibly due to atypical right sensorimotor engagement.

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来源期刊
Children-Basel
Children-Basel PEDIATRICS-
CiteScore
2.70
自引率
16.70%
发文量
1735
审稿时长
6 weeks
期刊介绍: Children is an international, open access journal dedicated to a streamlined, yet scientifically rigorous, dissemination of peer-reviewed science related to childhood health and disease in developed and developing countries. The publication focuses on sharing clinical, epidemiological and translational science relevant to children’s health. Moreover, the primary goals of the publication are to highlight under‑represented pediatric disciplines, to emphasize interdisciplinary research and to disseminate advances in knowledge in global child health. In addition to original research, the journal publishes expert editorials and commentaries, clinical case reports, and insightful communications reflecting the latest developments in pediatric medicine. By publishing meritorious articles as soon as the editorial review process is completed, rather than at predefined intervals, Children also permits rapid open access sharing of new information, allowing us to reach the broadest audience in the most expedient fashion.
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