胶原蛋白基质与聚脱氧核苷酸对颊部植入物影响的临床前研究

Chang-Hoon Kim, Ji-Youn Hong, SeungIl Shin, Seung-Yun Shin, Jong-Hyuk Chung, Daniel S Thoma, Hyun-Chang Lim
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引用次数: 0

摘要

研究目的本研究旨在探讨两种浓度的聚脱氧核苷酸(PDRN)胶原基质对犬颊侧种植体角化组织(KT)再生的影响:在切除 KT 的同时,在五只犬的无牙下颌植入了四个种植体。种植体的颊侧位置与牙脊嵴相关。2 个月后,采用以下治疗方式进行 KT 增量:(1) 游离牙龈移植 (FGG);(2) 异种胶原基质 (XCM);(3) 含有 2 毫克/毫升 PDRN 的 XCM (PDRN2);(4) 含有 4 毫克/毫升 PDRN 的 XCM (PDRN4)。所有动物均在 3 个月后处死。结果包括临床(KT 高度)和组织形态测量(KT 高度/长度、粘膜水平、粘膜厚度、上软组织高度):3个月时,临床和组织形态测量的KT形成在FGG组(4.70 ± 1.00/3.94 ± 0.93 mm)和PDRN2组(4.85 ± 1.43/3.95 ± 0.87 mm)最大。与其他组相比,PDRN2 组(1.87 ± 1.50 mm)与种植体平台的边缘粘膜水平更高(范围:0.57 ± 0.97-0.69 ± 1.14 mm)。所有组的软组织厚度均符合结论:基于这项临床前试验研究的局限性,含有 2 毫克/毫升 PDRN 的 XCM 显示出了 KT 增量的潜力。
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Preclinical Investigation on the Effect of Collagen Matrix With Polydeoxyribonucleotide at Buccally Positioned Implants.

Objectives: The objective of this study is to investigate the effect of collagen matrix with polydeoxyribonucleotide (PDRN) at two concentrations on keratinized tissue (KT) regeneration for buccally positioned implants in canines.

Methods: Four implants were placed in the edentulous mandible of five dogs simultaneously with KT removal. The implants were positioned buccally with respect to the ridge crest. After 2 months, KT augmentation was performed applying the following treatment modalities:(1) free gingival graft (FGG), (2) xenogeneic collagen matrix (XCM), (3) XCM loaded with 2 mg/mL PDRN (PDRN2), and (4) XCM loaded with 4 mg/mL PDRN (PDRN4). All animals were sacrificed 3 months later. Outcomes included clinical (KT height) and histomorphometric measurements (KT height/length, level of the mucosa, mucosal thickness, supracrestal soft tissue height).

Results: Clinical and histomorphometric KT formation at 3 months was greatest in groups with FGG (4.70 ± 1.00/3.94 ± 0.93 mm) and PDRN2 (4.85 ± 1.43/3.95 ± 0.87 mm). Group PDRN2 (1.87 ± 1.50 mm) showed a higher marginal mucosal level with respect to the implant platform compared to other groups (range: 0.57 ± 0.97-0.69 ± 1.14 mm). All groups presented a soft tissue thickness of < 2 mm on the buccal aspect of the implants.

Conclusions: Based on the limitations of this pilot preclinical study, XCM with 2 mg/mL of PDRN demonstrated a potential for KT augmentation.

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