硅氧烷类脂质的微小结构变化可改善组织特异性 mRNA 递送

IF 38.1 1区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Nature nanotechnology Pub Date : 2024-10-28 DOI:10.1038/s41565-024-01748-5

引用次数: 0

摘要

从单一的硅氧烷类脂质库中，硅氧烷包合脂质纳米颗粒（SiLNPs）在脂质化学性质上稍作改变，就能将组织特异性 mRNA 运送到肝脏、肺部或脾脏。这些 SiLNPs 在增强细胞内递送后，在蛋白质替代疗法、再生医学和基于 CRISPR-Cas 的基因编辑应用方面显示出临床前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Small structural changes in siloxane-based lipidoids improve tissue-specific mRNA delivery

From a single library of siloxane-based lipidoids, siloxane-incorporated lipid nanoparticles (SiLNPs) involving minor alterations in lipid chemistry yield tissue-specific mRNA delivery to the liver, lung, or spleen. Upon enhanced intracellular delivery, these SiLNPs show clinical promise for protein replacement therapies, regenerative medicine, and CRISPR–Cas-based gene editing applications.

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来源期刊

Nature nanotechnology 工程技术-材料科学：综合

CiteScore

59.70

自引率

0.80%

发文量

196

审稿时长

4-8 weeks

期刊介绍： Nature Nanotechnology is a prestigious journal that publishes high-quality papers in various areas of nanoscience and nanotechnology. The journal focuses on the design, characterization, and production of structures, devices, and systems that manipulate and control materials at atomic, molecular, and macromolecular scales. It encompasses both bottom-up and top-down approaches, as well as their combinations. Furthermore, Nature Nanotechnology fosters the exchange of ideas among researchers from diverse disciplines such as chemistry, physics, material science, biomedical research, engineering, and more. It promotes collaboration at the forefront of this multidisciplinary field. The journal covers a wide range of topics, from fundamental research in physics, chemistry, and biology, including computational work and simulations, to the development of innovative devices and technologies for various industrial sectors such as information technology, medicine, manufacturing, high-performance materials, energy, and environmental technologies. It includes coverage of organic, inorganic, and hybrid materials.

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