微小蛋白可能产生重大影响：自身免疫疾病及其他疾病的新疗法

IF 40.8 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Signal Transduction and Targeted Therapy Pub Date : 2024-10-28 DOI:10.1038/s41392-024-02010-z

Nariaki Asada, Christian F. Krebs, Ulf Panzer

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引用次数: 0

摘要

在最近发表于《细胞》（Cell）杂志的一项具有里程碑意义的研究中，Berger 等人证明，通过计算设计的小蛋白可以通过有效抑制体内配体与受体之间的相互作用，特异性地靶向细胞因子信号通路，从而成为新型的口服治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Miniproteins may have a big impact: new therapeutics for autoimmune diseases and beyond

In a landmark study recently published in Cell, Berger et al. demonstrated that computationally designed miniproteins could serve as novel, orally available treatment strategies by specifically targeting cytokine signaling pathways through the potent inhibition of ligand-receptor interactions in the body.¹ This breakthrough study unveils the potential for miniprotein-based therapies to revolutionize molecular treatment strategies for autoimmune diseases and cancers.

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来源期刊

Signal Transduction and Targeted Therapy Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

44.50

自引率

1.50%

发文量

384

审稿时长

5 weeks

期刊介绍： Signal Transduction and Targeted Therapy is an open access journal that focuses on timely publication of cutting-edge discoveries and advancements in basic science and clinical research related to signal transduction and targeted therapy. Scope: The journal covers research on major human diseases, including, but not limited to: Cancer,Cardiovascular diseases,Autoimmune diseases,Nervous system diseases.