Nathan Vidal, Eric Brunet-Gouet, Solène Frileux, Valérie Aubin, Raoul Belzeaux, Philippe Courtet, Thierry D’Amato, Caroline Dubertret, Bruno Etain, Sebastien Gard, Emmanuel Haffen, Dominique Januel, Marion Leboyer, Antoine Lefrere, Pierre-Michel Llorca, Emeline Marlinge, Emilie Olié, Mircea Polosan, Raymund Schwan, Michel Walter, The FACE-BD (FondaMental Academic Centers of Expertise for Bipolar Disorders) group, Christine Passerieux, Paul Roux
{"title":"探索双相情感障碍 \"缓解期 \"残余情绪症状与自述副作用之间的关联：横断面网络分析","authors":"Nathan Vidal, Eric Brunet-Gouet, Solène Frileux, Valérie Aubin, Raoul Belzeaux, Philippe Courtet, Thierry D’Amato, Caroline Dubertret, Bruno Etain, Sebastien Gard, Emmanuel Haffen, Dominique Januel, Marion Leboyer, Antoine Lefrere, Pierre-Michel Llorca, Emeline Marlinge, Emilie Olié, Mircea Polosan, Raymund Schwan, Michel Walter, The FACE-BD (FondaMental Academic Centers of Expertise for Bipolar Disorders) group, Christine Passerieux, Paul Roux","doi":"10.1155/2024/3375145","DOIUrl":null,"url":null,"abstract":"<div>\n <p><b>Introduction:</b> Bipolar disorders (BD) are characterized by mood symptoms that can worsen medication side effects. We aimed to study the association between residual mood signs and self-reported side effects in the euthymic phase of BD.</p>\n <p><b>Methods:</b> We assessed residual mood signs using the Montgomery–Asberg Depression Rating scale (MADRS) and Young Mania Rating scale (YMRS) and self-reported side effects using the Patient-Rated Inventory of Side Effects (PRISE-M) for 880 males and 1369 females with BD. We conducted a network analysis to test the associations between 52 items of the three scales for males and females separately. We then identified clusters of nodes that fit the networks well.</p>\n <p><b>Results:</b> We report only positive associations between residual mood signs and side effects. An elevated mood (YMRS) in females and increased energy (YMRS) in males were central nodes, strongly influencing the development of additional mood symptoms and side effects. Furthermore, we identified three clusters of nodes in both sexes: (1) a “mood cluster”, including most YMRS and MADRS items and the PRISE-M items evaluating sedation, sleep, and restlessness, (2) a cluster of nonsexual side effects (mostly PRISE-M items), and (3) a cluster of sexual side effects. In both sexes, we identified bridge nodes that may favor the communication between mood and side effects, namely palpitations (PRISE-M) and agitation (PRISE-M).</p>\n <p><b>Conclusions:</b> The results justify the particular attention of practitioners to monitor elevated moods or increased energy to try to reduce self-reported side effects and other residual mood symptoms in the euthymic phase of BD. Our findings suggest that clinicians could consider patient-reported loss of energy, difficulty in falling asleep, and restlessness as mood symptoms rather than medications’ side effects. Palpitations and agitation may contribute to the development of additional mood symptoms or somatic complaints.</p>\n </div>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":null,"pages":null},"PeriodicalIF":4.7000,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/3375145","citationCount":"0","resultStr":"{\"title\":\"Exploring the Association Between Residual Mood Symptoms and Self-Reported Side Effects in the Euthymic Phase of Bipolar Disorders: A Cross-Sectional Network Analysis\",\"authors\":\"Nathan Vidal, Eric Brunet-Gouet, Solène Frileux, Valérie Aubin, Raoul Belzeaux, Philippe Courtet, Thierry D’Amato, Caroline Dubertret, Bruno Etain, Sebastien Gard, Emmanuel Haffen, Dominique Januel, Marion Leboyer, Antoine Lefrere, Pierre-Michel Llorca, Emeline Marlinge, Emilie Olié, Mircea Polosan, Raymund Schwan, Michel Walter, The FACE-BD (FondaMental Academic Centers of Expertise for Bipolar Disorders) group, Christine Passerieux, Paul Roux\",\"doi\":\"10.1155/2024/3375145\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n <p><b>Introduction:</b> Bipolar disorders (BD) are characterized by mood symptoms that can worsen medication side effects. 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Furthermore, we identified three clusters of nodes in both sexes: (1) a “mood cluster”, including most YMRS and MADRS items and the PRISE-M items evaluating sedation, sleep, and restlessness, (2) a cluster of nonsexual side effects (mostly PRISE-M items), and (3) a cluster of sexual side effects. In both sexes, we identified bridge nodes that may favor the communication between mood and side effects, namely palpitations (PRISE-M) and agitation (PRISE-M).</p>\\n <p><b>Conclusions:</b> The results justify the particular attention of practitioners to monitor elevated moods or increased energy to try to reduce self-reported side effects and other residual mood symptoms in the euthymic phase of BD. Our findings suggest that clinicians could consider patient-reported loss of energy, difficulty in falling asleep, and restlessness as mood symptoms rather than medications’ side effects. 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Exploring the Association Between Residual Mood Symptoms and Self-Reported Side Effects in the Euthymic Phase of Bipolar Disorders: A Cross-Sectional Network Analysis
Introduction: Bipolar disorders (BD) are characterized by mood symptoms that can worsen medication side effects. We aimed to study the association between residual mood signs and self-reported side effects in the euthymic phase of BD.
Methods: We assessed residual mood signs using the Montgomery–Asberg Depression Rating scale (MADRS) and Young Mania Rating scale (YMRS) and self-reported side effects using the Patient-Rated Inventory of Side Effects (PRISE-M) for 880 males and 1369 females with BD. We conducted a network analysis to test the associations between 52 items of the three scales for males and females separately. We then identified clusters of nodes that fit the networks well.
Results: We report only positive associations between residual mood signs and side effects. An elevated mood (YMRS) in females and increased energy (YMRS) in males were central nodes, strongly influencing the development of additional mood symptoms and side effects. Furthermore, we identified three clusters of nodes in both sexes: (1) a “mood cluster”, including most YMRS and MADRS items and the PRISE-M items evaluating sedation, sleep, and restlessness, (2) a cluster of nonsexual side effects (mostly PRISE-M items), and (3) a cluster of sexual side effects. In both sexes, we identified bridge nodes that may favor the communication between mood and side effects, namely palpitations (PRISE-M) and agitation (PRISE-M).
Conclusions: The results justify the particular attention of practitioners to monitor elevated moods or increased energy to try to reduce self-reported side effects and other residual mood symptoms in the euthymic phase of BD. Our findings suggest that clinicians could consider patient-reported loss of energy, difficulty in falling asleep, and restlessness as mood symptoms rather than medications’ side effects. Palpitations and agitation may contribute to the development of additional mood symptoms or somatic complaints.
期刊介绍：
Depression and Anxiety is a scientific journal that focuses on the study of mood and anxiety disorders, as well as related phenomena in humans. The journal is dedicated to publishing high-quality research and review articles that contribute to the understanding and treatment of these conditions. The journal places a particular emphasis on articles that contribute to the clinical evaluation and care of individuals affected by mood and anxiety disorders. It prioritizes the publication of treatment-related research and review papers, as well as those that present novel findings that can directly impact clinical practice. The journal's goal is to advance the field by disseminating knowledge that can lead to better diagnosis, treatment, and management of these disorders, ultimately improving the quality of life for those who suffer from them.
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