利用有信息的分层收缩分区先验对计算机鼠标跟踪数据进行聚类。

IF 1.4 4区 数学 Q3 BIOLOGY Biometrics Pub Date : 2024-10-03 DOI:10.1093/biomtc/ujae124
Ziyi Song, Weining Shen, Marina Vannucci, Alexandria Baldizon, Paul M Cinciripini, Francesco Versace, Michele Guindani
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引用次数: 0

摘要

鼠标跟踪数据记录了参与者执行实验任务时电脑鼠标的轨迹,为了解受试者的基本认知过程提供了宝贵的信息。神经科学家们有兴趣将受试者在电脑鼠标跟踪任务中的反应进行聚类,以揭示个体决策行为的模式,并识别具有类似神经行为反应的人群亚群。这些数据可与神经影像学数据相结合,为个性化干预提供更多信息。在本文中,我们开发了一种新颖的分层收缩分割(HSP)先验,用于对小鼠追踪数据轨迹得出的汇总统计数据进行聚类。HSP 模型将受试者聚类定义为一组受试者,这组受试者会产生更多相似(而非相同)的条件嵌套分区。所提出的模型可以结合有关受试者或条件分区的先验信息来促进聚类,并允许每个受试者组内的嵌套分区出现偏差。这些特点使 HSP 模型有别于其他双聚类方法,后者通常在一个受试者组内创建相同的条件嵌套分区。此外,它也有别于现有的嵌套聚类方法,后者根据抽样模型中的共同参数定义聚类,并通过不同的分布确定受试者组。我们在一项试验研究的小鼠跟踪数据集和模拟研究中说明了 HSP 模型的独特功能。我们的研究结果表明了所提出的探索性框架在聚类和揭示受试者群体间可能存在的不同行为模式方面的能力和有效性。
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Clustering computer mouse tracking data with informed hierarchical shrinkage partition priors.

Mouse-tracking data, which record computer mouse trajectories while participants perform an experimental task, provide valuable insights into subjects' underlying cognitive processes. Neuroscientists are interested in clustering the subjects' responses during computer mouse-tracking tasks to reveal patterns of individual decision-making behaviors and identify population subgroups with similar neurobehavioral responses. These data can be combined with neuroimaging data to provide additional information for personalized interventions. In this article, we develop a novel hierarchical shrinkage partition (HSP) prior for clustering summary statistics derived from the trajectories of mouse-tracking data. The HSP model defines a subjects' cluster as a set of subjects that gives rise to more similar (rather than identical) nested partitions of the conditions. The proposed model can incorporate prior information about the partitioning of either subjects or conditions to facilitate clustering, and it allows for deviations of the nested partitions within each subject group. These features distinguish the HSP model from other bi-clustering methods that typically create identical nested partitions of conditions within a subject group. Furthermore, it differs from existing nested clustering methods, which define clusters based on common parameters in the sampling model and identify subject groups by different distributions. We illustrate the unique features of the HSP model on a mouse tracking dataset from a pilot study and in simulation studies. Our results show the ability and effectiveness of the proposed exploratory framework in clustering and revealing possible different behavioral patterns across subject groups.

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来源期刊
Biometrics
Biometrics 生物-生物学
CiteScore
2.70
自引率
5.30%
发文量
178
审稿时长
4-8 weeks
期刊介绍: The International Biometric Society is an international society promoting the development and application of statistical and mathematical theory and methods in the biosciences, including agriculture, biomedical science and public health, ecology, environmental sciences, forestry, and allied disciplines. The Society welcomes as members statisticians, mathematicians, biological scientists, and others devoted to interdisciplinary efforts in advancing the collection and interpretation of information in the biosciences. The Society sponsors the biennial International Biometric Conference, held in sites throughout the world; through its National Groups and Regions, it also Society sponsors regional and local meetings.
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