Yahong Tan, Wenjia Liu, Yanhua Li, Nan Zhang, Mingxiao Wang, Shuo Sun, Lin Ma
{"title":"利用 1H 磁共振波谱温度计测量健康成年人的脑温","authors":"Yahong Tan, Wenjia Liu, Yanhua Li, Nan Zhang, Mingxiao Wang, Shuo Sun, Lin Ma","doi":"10.1007/s00062-024-01467-3","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study is to measure the brain temperature (T<sub>br</sub>) by using <sup>1</sup>H magnetic resonance spectroscopy (<sup>1</sup>H MRS) thermometry and investigate its age and gender differences in healthy adults. The brain temperature was further compared with the body temperature (T<sub>bo</sub>) to investigate the possible existence of brain-body temperature gradient (∆T).</p><p><strong>Methods: </strong>A total of 80 subjects were included in this study. <sup>1</sup>H MRS data were collected on a 3.0T MR scanner using Point Resolved Selective Spectroscopy (PRESS) sequence. Voxels were positioned in the right frontal (RF) lobe and left frontal (LF) lobe, respectively. The temperature of each voxel was calculated by chemical shift difference (∆δ) between H<sub>2</sub>O and NAA which was obtained by LCModel software. The average temperature of bilateral frontal lobe voxels was defined as T<sub>br</sub> for each subject. The average forehead temperature was acquired before MR scanning, defined as T<sub>bo</sub>, in this study. The difference between T<sub>br</sub> and T<sub>bo</sub>, denoted as the brain-body temperature gradient (∆T), was calculated. Age and gender characteristics of T<sub>br</sub>, ∆T and T<sub>bo</sub> were analyzed.</p><p><strong>Results: </strong>T<sub>br</sub> (38.51 ± 0.59℃) was higher than T<sub>bo</sub> (36.47 ± 0.26℃) (P < 0.05). Negative correlations were observed between T<sub>br</sub> and age (r = -0.49, P < 0.05) and between ∆T and age (r = -0.44, P < 0.05), whereas no correlation existed between T<sub>bo</sub> and age (r = -0.03, P = 0.79).</p><p><strong>Conclusion: </strong>Our observation demonstrated that the brain temperature, derived from <sup>1</sup>H MRS thermometry, is significantly higher than the body temperature, indicating the existence of a brain-body temperature gradient, and the brain temperature gradually decreases with age.</p>","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":null,"pages":null},"PeriodicalIF":2.8000,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Measurement of Healthy Adult Brain Temperature Using <sup>1</sup>H Magnetic Resonance Spectroscopy Thermometry.\",\"authors\":\"Yahong Tan, Wenjia Liu, Yanhua Li, Nan Zhang, Mingxiao Wang, Shuo Sun, Lin Ma\",\"doi\":\"10.1007/s00062-024-01467-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>The purpose of this study is to measure the brain temperature (T<sub>br</sub>) by using <sup>1</sup>H magnetic resonance spectroscopy (<sup>1</sup>H MRS) thermometry and investigate its age and gender differences in healthy adults. The brain temperature was further compared with the body temperature (T<sub>bo</sub>) to investigate the possible existence of brain-body temperature gradient (∆T).</p><p><strong>Methods: </strong>A total of 80 subjects were included in this study. <sup>1</sup>H MRS data were collected on a 3.0T MR scanner using Point Resolved Selective Spectroscopy (PRESS) sequence. Voxels were positioned in the right frontal (RF) lobe and left frontal (LF) lobe, respectively. The temperature of each voxel was calculated by chemical shift difference (∆δ) between H<sub>2</sub>O and NAA which was obtained by LCModel software. The average temperature of bilateral frontal lobe voxels was defined as T<sub>br</sub> for each subject. The average forehead temperature was acquired before MR scanning, defined as T<sub>bo</sub>, in this study. The difference between T<sub>br</sub> and T<sub>bo</sub>, denoted as the brain-body temperature gradient (∆T), was calculated. Age and gender characteristics of T<sub>br</sub>, ∆T and T<sub>bo</sub> were analyzed.</p><p><strong>Results: </strong>T<sub>br</sub> (38.51 ± 0.59℃) was higher than T<sub>bo</sub> (36.47 ± 0.26℃) (P < 0.05). Negative correlations were observed between T<sub>br</sub> and age (r = -0.49, P < 0.05) and between ∆T and age (r = -0.44, P < 0.05), whereas no correlation existed between T<sub>bo</sub> and age (r = -0.03, P = 0.79).</p><p><strong>Conclusion: </strong>Our observation demonstrated that the brain temperature, derived from <sup>1</sup>H MRS thermometry, is significantly higher than the body temperature, indicating the existence of a brain-body temperature gradient, and the brain temperature gradually decreases with age.</p>\",\"PeriodicalId\":10391,\"journal\":{\"name\":\"Clinical Neuroradiology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.8000,\"publicationDate\":\"2024-10-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Neuroradiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s00062-024-01467-3\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Neuroradiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00062-024-01467-3","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
Measurement of Healthy Adult Brain Temperature Using 1H Magnetic Resonance Spectroscopy Thermometry.
Purpose: The purpose of this study is to measure the brain temperature (Tbr) by using 1H magnetic resonance spectroscopy (1H MRS) thermometry and investigate its age and gender differences in healthy adults. The brain temperature was further compared with the body temperature (Tbo) to investigate the possible existence of brain-body temperature gradient (∆T).
Methods: A total of 80 subjects were included in this study. 1H MRS data were collected on a 3.0T MR scanner using Point Resolved Selective Spectroscopy (PRESS) sequence. Voxels were positioned in the right frontal (RF) lobe and left frontal (LF) lobe, respectively. The temperature of each voxel was calculated by chemical shift difference (∆δ) between H2O and NAA which was obtained by LCModel software. The average temperature of bilateral frontal lobe voxels was defined as Tbr for each subject. The average forehead temperature was acquired before MR scanning, defined as Tbo, in this study. The difference between Tbr and Tbo, denoted as the brain-body temperature gradient (∆T), was calculated. Age and gender characteristics of Tbr, ∆T and Tbo were analyzed.
Results: Tbr (38.51 ± 0.59℃) was higher than Tbo (36.47 ± 0.26℃) (P < 0.05). Negative correlations were observed between Tbr and age (r = -0.49, P < 0.05) and between ∆T and age (r = -0.44, P < 0.05), whereas no correlation existed between Tbo and age (r = -0.03, P = 0.79).
Conclusion: Our observation demonstrated that the brain temperature, derived from 1H MRS thermometry, is significantly higher than the body temperature, indicating the existence of a brain-body temperature gradient, and the brain temperature gradually decreases with age.
期刊介绍：
Clinical Neuroradiology provides current information, original contributions, and reviews in the field of neuroradiology. An interdisciplinary approach is accomplished by diagnostic and therapeutic contributions related to associated subjects.
The international coverage and relevance of the journal is underlined by its being the official journal of the German, Swiss, and Austrian Societies of Neuroradiology.
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