曲哈洛糖:神经保护作用和机制--最新综述

IF 1.6 Q3 CLINICAL NEUROLOGY NeuroSci Pub Date : 2024-10-12 eCollection Date: 2024-12-01 DOI:10.3390/neurosci5040032
Borislav Sevriev, Simeonka Dimitrova, Gabriela Kehayova, Stela Dragomanova
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引用次数: 0

摘要

曲哈洛糖是一种天然双糖,最近因其在各种神经变性模型中的神经保护特性而备受关注。本综述概述了有关曲哈洛糖对中枢神经系统病变有益特性的现有实验数据。我们还研究了曲哈洛糖对神经细胞存活和功能的影响。结果我们发现,曲哈洛糖的神经保护作用包括自噬调节以及稳定蛋白质和抑制错误折叠蛋白质形成的能力。此外,曲哈洛糖还能通过稳定细胞膜和调节线粒体功能来减轻氧化应激引起的神经元损伤。此外,曲哈洛糖还能抑制促炎细胞因子的释放和炎性体的激活,从而减轻兴奋性毒性诱发的神经炎症。研究还探讨了三卤糖与肠道-大脑轴的可能联系。这些发现凸显了三卤糖对神经退行性疾病的潜在治疗作用。根据这项研究得出的结论,由于其独特的作用机制,曲哈洛糖是一种很有前景的神经保护剂,这使得这种化合物成为进一步研究和开发治疗策略的候选物质,以对抗神经元损伤并促进各种神经系统疾病的神经保护。
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Trehalose: Neuroprotective Effects and Mechanisms-An Updated Review.

Trehalose is a naturally occurring disaccharide that has recently gained significant attention for its neuroprotective properties in various models of neurodegeneration. This review provides an overview of available experimental data on the beneficial properties of trehalose for central nervous system pathological conditions. Trehalose's impact on neuronal cell survival and function was also examined. As a result, we identified that trehalose's neuroprotection includes autophagy modulation as well as its capability to stabilize proteins and inhibit the formation of misfolded ones. Moreover, trehalose mitigates oxidative stress-induced neuronal damage by stabilizing cellular membranes and modulating mitochondrial function. Furthermore, trehalose attenuates excitotoxicity-induced neuroinflammation by suppressing pro-inflammatory cytokine release and inhibiting inflammasome activation. A possible connection of trehalose with the gut-brain axis was also examined. These findings highlight the potential therapeutic effects of trehalose in neurodegenerative diseases. According to the conclusions drawn from this study, trehalose is a promising neuroprotective agent as a result of its distinct mechanism of action, which makes this compound a candidate for further research and the development of therapeutic strategies to combat neuronal damage and promote neuroprotection in various neurological diseases.

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期刊最新文献
Exploring Neuroprotection against Radiation-Induced Brain Injury: A Review of Key Compounds. Resting-State Functional Connectivity Predicts Attention Problems in Children: Evidence from the ABCD Study. Trehalose: Neuroprotective Effects and Mechanisms-An Updated Review. Discontinuation of Cerebro-Spinal Fluid (CSF) Drainage in Acute Hydrocephalus: A Prospective Cohort Study and Exploratory Data Analysis. Wearable EEG-Based Brain-Computer Interface for Stress Monitoring.
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