Ana I. Silva Terra, Daniel A. Taylor, Meghan E. Halse
{"title":"用于分析应用的超极化台式 NMR 光谱仪","authors":"Ana I. Silva Terra, Daniel A. Taylor, Meghan E. Halse","doi":"10.1016/j.pnmrs.2024.10.001","DOIUrl":null,"url":null,"abstract":"<div><div>Benchtop NMR spectrometers, with moderate magnetic field strengths (<span><math><mrow><msub><mrow><mi>B</mi></mrow><mrow><mn>0</mn></mrow></msub><mo>=</mo><mn>1</mn><mo>−</mo><mn>2</mn><mo>.</mo><mn>4</mn><mspace></mspace><mi>T</mi></mrow></math></span>) and sub-ppm chemical shift resolution, are an affordable and portable alternative to standard laboratory NMR (<span><math><mrow><msub><mrow><mi>B</mi></mrow><mrow><mn>0</mn></mrow></msub><mo>≥</mo><mn>7</mn><mspace></mspace><mi>T</mi></mrow></math></span>). However, in moving to lower magnetic field instruments, sensitivity and chemical shift resolution are significantly reduced. The sensitivity limitation can be overcome by using hyperpolarisation to boost benchtop NMR signals by orders of magnitude. Of the wide range of hyperpolarisation methods currently available, dynamic nuclear polarisation (DNP), <em>para</em>hydrogen-induced polarisation (PHIP) and photochemically-induced dynamic nuclear polarisation (photo-CIDNP) have, to date, shown the most promise for integration with benchtop NMR for analytical applications. In this review we provide a summary of the theory of each of these techniques and discuss examples of how they have been integrated with benchtop NMR detection. Progress towards the use of hyperpolarised benchtop NMR for analytical applications, ranging from reaction monitoring to probing biomolecular interactions, is discussed, along with perspectives for the future.</div></div>","PeriodicalId":20740,"journal":{"name":"Progress in Nuclear Magnetic Resonance Spectroscopy","volume":"144 ","pages":"Pages 153-178"},"PeriodicalIF":7.3000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Hyperpolarised benchtop NMR spectroscopy for analytical applications\",\"authors\":\"Ana I. Silva Terra, Daniel A. Taylor, Meghan E. Halse\",\"doi\":\"10.1016/j.pnmrs.2024.10.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Benchtop NMR spectrometers, with moderate magnetic field strengths (<span><math><mrow><msub><mrow><mi>B</mi></mrow><mrow><mn>0</mn></mrow></msub><mo>=</mo><mn>1</mn><mo>−</mo><mn>2</mn><mo>.</mo><mn>4</mn><mspace></mspace><mi>T</mi></mrow></math></span>) and sub-ppm chemical shift resolution, are an affordable and portable alternative to standard laboratory NMR (<span><math><mrow><msub><mrow><mi>B</mi></mrow><mrow><mn>0</mn></mrow></msub><mo>≥</mo><mn>7</mn><mspace></mspace><mi>T</mi></mrow></math></span>). However, in moving to lower magnetic field instruments, sensitivity and chemical shift resolution are significantly reduced. The sensitivity limitation can be overcome by using hyperpolarisation to boost benchtop NMR signals by orders of magnitude. Of the wide range of hyperpolarisation methods currently available, dynamic nuclear polarisation (DNP), <em>para</em>hydrogen-induced polarisation (PHIP) and photochemically-induced dynamic nuclear polarisation (photo-CIDNP) have, to date, shown the most promise for integration with benchtop NMR for analytical applications. In this review we provide a summary of the theory of each of these techniques and discuss examples of how they have been integrated with benchtop NMR detection. Progress towards the use of hyperpolarised benchtop NMR for analytical applications, ranging from reaction monitoring to probing biomolecular interactions, is discussed, along with perspectives for the future.</div></div>\",\"PeriodicalId\":20740,\"journal\":{\"name\":\"Progress in Nuclear Magnetic Resonance Spectroscopy\",\"volume\":\"144 \",\"pages\":\"Pages 153-178\"},\"PeriodicalIF\":7.3000,\"publicationDate\":\"2024-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Progress in Nuclear Magnetic Resonance Spectroscopy\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0079656524000232\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, PHYSICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Progress in Nuclear Magnetic Resonance Spectroscopy","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0079656524000232","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
Hyperpolarised benchtop NMR spectroscopy for analytical applications
Benchtop NMR spectrometers, with moderate magnetic field strengths () and sub-ppm chemical shift resolution, are an affordable and portable alternative to standard laboratory NMR (). However, in moving to lower magnetic field instruments, sensitivity and chemical shift resolution are significantly reduced. The sensitivity limitation can be overcome by using hyperpolarisation to boost benchtop NMR signals by orders of magnitude. Of the wide range of hyperpolarisation methods currently available, dynamic nuclear polarisation (DNP), parahydrogen-induced polarisation (PHIP) and photochemically-induced dynamic nuclear polarisation (photo-CIDNP) have, to date, shown the most promise for integration with benchtop NMR for analytical applications. In this review we provide a summary of the theory of each of these techniques and discuss examples of how they have been integrated with benchtop NMR detection. Progress towards the use of hyperpolarised benchtop NMR for analytical applications, ranging from reaction monitoring to probing biomolecular interactions, is discussed, along with perspectives for the future.
期刊介绍：
Progress in Nuclear Magnetic Resonance Spectroscopy publishes review papers describing research related to the theory and application of NMR spectroscopy. This technique is widely applied in chemistry, physics, biochemistry and materials science, and also in many areas of biology and medicine. The journal publishes review articles covering applications in all of these and in related subjects, as well as in-depth treatments of the fundamental theory of and instrumental developments in NMR spectroscopy.
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