夜班工作与生物衰老的关系:体重指数的中介作用。

IF 6 2区 医学 Q1 GERIATRICS & GERONTOLOGY Age and ageing Pub Date : 2024-11-01 DOI:10.1093/ageing/afae242
Wenqi Shen, Lingli Cai, Jiang Li, Ying Sun, Bin Wang, Ningjian Wang, Yingli Lu
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引用次数: 0

摘要

背景:我们旨在研究当前和终生夜班工作是否与加速生物衰老有关,以及体重指数(BMI)在调节这种关联中的潜在作用:数据来源于英国生物库队列。方法:数据来源于英国生物库队列。这项研究的参与者详细报告了他们目前的工作时间安排,并提供了计算 PhenoAge 的完整数据。研究结果是生物老化,通过 PhenoAge 加速度进行测量。我们建立了多变量线性回归模型,以检验夜班工作与生物衰老之间的关系。还进行了中介分析:在 182 064 名参与者中,平均年龄为 52.6 岁,51.1% 为男性。在对实际年龄和性别进行调整后,与白班工人相比,无夜班的轮班工人、不定时夜班工人和长期夜班工人的生物衰老分别增加了 0.59 年、0.87 年和 1.30 年(P 为 10 年趋势),每月夜班次数大于 8 次的参与者的生物衰老加速度增加[大于 10 年:β = 0.54,95% 置信区间(CI)为 0.29-0.79;大于 8 次/月:β = 0.29,95% 置信区间(CI)为 0.07-0.50]。中介分析表明,体重指数对夜班工作与生物年龄加速度之间的关联有36%-53%的中介作用:我们的研究结果表明,夜班工作与加速生物衰老有关。结论:我们的研究结果表明,夜班工作与生物衰老加速有关。我们的研究结果突出表明,对夜班工人进行适当的轮班工作时间安排和体重管理干预,可延缓生物衰老过程,最终减轻老年相关疾病的负担。
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Association of night shift work and biological ageing: the mediating role of body mass index.

Background: We aimed to examine whether current and lifetime night shift work is associated with accelerated biological ageing and the potential role of body mass index (BMI) in mediating the association.

Methods: Data were sourced from the UK Biobank cohort. This study included participants who reported detailed information on their current work schedule and had complete data to calculate PhenoAge. The outcome of interest was biological ageing, measured by PhenoAge acceleration. Multivariable linear regression models were conducted to test the relationship between night shift work and biological ageing. Mediation analyses were performed.

Results: Of the 182 064 participants included, the mean age was 52.6 years, and 51.1% were male. After adjustment for chronological age and sex, compared with day workers, shift workers without night shift, irregular night shift workers and permanent night shift workers were associated with 0.59-, 0.87- and 1.30-year increase in biological ageing, respectively (P for trend <.001). Considering the lifetime work schedule, participants who worked night shifts >10 years and participants who worked >8 night shifts each month showed increased biological age acceleration [>10 years: β = 0.54, 95% confidence interval (CI) 0.29-0.79; >8 times/month: β = 0.29, 95% CI 0.07-0.50]. The mediation analysis showed that BMI mediated the associations between night shift work and biological age acceleration by 36%-53%.

Conclusions: We showed that night shift work was associated with accelerated biological ageing. Our findings highlight the interventions on appropriate shift work schedules and weight management in night shift workers, which may slow the biological ageing process and ultimately reduce the burden of age-related diseases.

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来源期刊
Age and ageing
Age and ageing 医学-老年医学
CiteScore
9.20
自引率
6.00%
发文量
796
审稿时长
4-8 weeks
期刊介绍: Age and Ageing is an international journal publishing refereed original articles and commissioned reviews on geriatric medicine and gerontology. Its range includes research on ageing and clinical, epidemiological, and psychological aspects of later life.
期刊最新文献
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