Haiping Wu , Jiayan Yang , Pengchao Wang , Ruofei Sun, Ting Wang, Xiali Liao, Bo Yang, Chuanzhu Gao, Jing Yang
{"title":"一系列环甲基化铂(II)配合物的一维、三维超分子组装,通过铂-铂相互作用实现深红色聚集诱导磷光发射和阴离子开启感应","authors":"Haiping Wu , Jiayan Yang , Pengchao Wang , Ruofei Sun, Ting Wang, Xiali Liao, Bo Yang, Chuanzhu Gao, Jing Yang","doi":"10.1016/j.bios.2024.116900","DOIUrl":null,"url":null,"abstract":"<div><div>Controlling the size and morphology of supramolecular assemblies is still an enormous challenge for the development of novel functional materials. Herein, cyclometalated platinum(II) complexes were designed and used as effective theragnostic supramolecular nano agents. Benzoquinoline was used as the main C^N ligand, and the increased number of aromatic rings in the N^N ligand of Pt complexes could greatly improve lipophilicity and cytotoxicity towards cancer cells over normal cells. Moreover, the morphology of nanoparticles formed by self-assembly of Pta-d could change from one to three-dimensional (1-3D), which can form nanowires and nanospheres. Besides, complexes of Pta-c, the number of aromatic rings in the N^N ligand of which does not exceed 4, all exhibit significant aggregation-induced phosphorescent emission (AIPE) with 100 - 200-fold enhancement in red phosphoresce intensity recorded in the solvent of Pta-1 and Ptb. Pt-Pt interaction induced by coordination and electrostatic interaction between complex and anions, and a new deep red emission improvement was observed in aqueous solution of Pta and Ptb with the presence of ClO<sub>4</sub><sup>−</sup>, and two similar deep red emissions induced by two different interactions can be told by new emerging MMLCT absorption band. Ptd of dppz ligand exhibits the highest efficiency in inducing apoptosis of HeLa and its anticancer mechanism was studied. Our work aims to promote the fundamental comprehension of the self-assembly behavior of cyclometalated platinum complex with AIPE in vitro and living cells.</div></div>","PeriodicalId":259,"journal":{"name":"Biosensors and Bioelectronics","volume":"268 ","pages":"Article 116900"},"PeriodicalIF":10.7000,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"1D, 3D supramolecular assemblies of a series of cyclometalated platinum(II) complexes with deep-red aggregation-induced phosphorescent emission and anion turn-on sensing via Pt-Pt interaction\",\"authors\":\"Haiping Wu , Jiayan Yang , Pengchao Wang , Ruofei Sun, Ting Wang, Xiali Liao, Bo Yang, Chuanzhu Gao, Jing Yang\",\"doi\":\"10.1016/j.bios.2024.116900\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Controlling the size and morphology of supramolecular assemblies is still an enormous challenge for the development of novel functional materials. Herein, cyclometalated platinum(II) complexes were designed and used as effective theragnostic supramolecular nano agents. Benzoquinoline was used as the main C^N ligand, and the increased number of aromatic rings in the N^N ligand of Pt complexes could greatly improve lipophilicity and cytotoxicity towards cancer cells over normal cells. Moreover, the morphology of nanoparticles formed by self-assembly of Pta-d could change from one to three-dimensional (1-3D), which can form nanowires and nanospheres. Besides, complexes of Pta-c, the number of aromatic rings in the N^N ligand of which does not exceed 4, all exhibit significant aggregation-induced phosphorescent emission (AIPE) with 100 - 200-fold enhancement in red phosphoresce intensity recorded in the solvent of Pta-1 and Ptb. Pt-Pt interaction induced by coordination and electrostatic interaction between complex and anions, and a new deep red emission improvement was observed in aqueous solution of Pta and Ptb with the presence of ClO<sub>4</sub><sup>−</sup>, and two similar deep red emissions induced by two different interactions can be told by new emerging MMLCT absorption band. Ptd of dppz ligand exhibits the highest efficiency in inducing apoptosis of HeLa and its anticancer mechanism was studied. Our work aims to promote the fundamental comprehension of the self-assembly behavior of cyclometalated platinum complex with AIPE in vitro and living cells.</div></div>\",\"PeriodicalId\":259,\"journal\":{\"name\":\"Biosensors and Bioelectronics\",\"volume\":\"268 \",\"pages\":\"Article 116900\"},\"PeriodicalIF\":10.7000,\"publicationDate\":\"2024-11-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biosensors and Bioelectronics\",\"FirstCategoryId\":\"1\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0956566324009072\",\"RegionNum\":1,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOPHYSICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biosensors and Bioelectronics","FirstCategoryId":"1","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0956566324009072","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOPHYSICS","Score":null,"Total":0}
1D, 3D supramolecular assemblies of a series of cyclometalated platinum(II) complexes with deep-red aggregation-induced phosphorescent emission and anion turn-on sensing via Pt-Pt interaction
Controlling the size and morphology of supramolecular assemblies is still an enormous challenge for the development of novel functional materials. Herein, cyclometalated platinum(II) complexes were designed and used as effective theragnostic supramolecular nano agents. Benzoquinoline was used as the main C^N ligand, and the increased number of aromatic rings in the N^N ligand of Pt complexes could greatly improve lipophilicity and cytotoxicity towards cancer cells over normal cells. Moreover, the morphology of nanoparticles formed by self-assembly of Pta-d could change from one to three-dimensional (1-3D), which can form nanowires and nanospheres. Besides, complexes of Pta-c, the number of aromatic rings in the N^N ligand of which does not exceed 4, all exhibit significant aggregation-induced phosphorescent emission (AIPE) with 100 - 200-fold enhancement in red phosphoresce intensity recorded in the solvent of Pta-1 and Ptb. Pt-Pt interaction induced by coordination and electrostatic interaction between complex and anions, and a new deep red emission improvement was observed in aqueous solution of Pta and Ptb with the presence of ClO4−, and two similar deep red emissions induced by two different interactions can be told by new emerging MMLCT absorption band. Ptd of dppz ligand exhibits the highest efficiency in inducing apoptosis of HeLa and its anticancer mechanism was studied. Our work aims to promote the fundamental comprehension of the self-assembly behavior of cyclometalated platinum complex with AIPE in vitro and living cells.
期刊介绍:
Biosensors & Bioelectronics, along with its open access companion journal Biosensors & Bioelectronics: X, is the leading international publication in the field of biosensors and bioelectronics. It covers research, design, development, and application of biosensors, which are analytical devices incorporating biological materials with physicochemical transducers. These devices, including sensors, DNA chips, electronic noses, and lab-on-a-chip, produce digital signals proportional to specific analytes. Examples include immunosensors and enzyme-based biosensors, applied in various fields such as medicine, environmental monitoring, and food industry. The journal also focuses on molecular and supramolecular structures for enhancing device performance.