英国生物库队列中血浆 n-3 脂肪酸水平与自述听力困难的横断面分析

IF 3 Prostaglandins, leukotrienes, and essential fatty acids Pub Date : 2024-04-01 DOI:10.1016/j.plefa.2024.102654

Michael I. McBurney , Nathan L. Tintle , Jason Westra , William S. Harris , Sharon E. Curhan

{"title":"英国生物库队列中血浆 n-3 脂肪酸水平与自述听力困难的横断面分析","authors":"Michael I. McBurney , Nathan L. Tintle , Jason Westra , William S. Harris , Sharon E. Curhan","doi":"10.1016/j.plefa.2024.102654","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Disabling hearing loss affects ∼430 million people globally. Fish consumption and long-chain n-3 polyunsaturated fatty acid (PUFA) intake were inversely associated with risk of hearing loss, but the association of plasma n-3 PUFAs and hearing loss is unclear.</div></div><div><h3>Objective</h3><div>To examine the associations between plasma n-3 PUFA fractions (as % of total fatty acids), i.e., DHA % and Other n-3 PUFA % (defined as total n-3 PUFA minus DHA), with self-reported hearing difficulty in a population-based cohort in the UK.</div></div><div><h3>Methods</h3><div>Our study includes 175,177 UK Biobank participants (40–69y, 54 % women) with data on plasma n-3 PUFA and hearing status. Baseline plasma PUFA levels were analyzed by nuclear magnetic resonance, and self-reported hearing difficulty was obtained by questionnaire between 2007 and 2010. Logistic regression was used to estimate age-adjusted odds ratios (ORs), multivariable-adjusted odds ratios (MVORs) by adjusting for 14 demographic, behavioral, biomarker and health-related potential confounders, and 95 % confidence intervals (CIs).</div></div><div><h3>Results</h3><div>Hearing difficulty was reported by 26.7 % of participants. Higher plasma n-3 PUFA levels were independently associated with lower odds of self-reported hearing difficulty. The prevalence of hearing difficulty rose across age strata (40–49y, 15.8 %; 50–59y, 24.9 % and 60+<em>y</em>, 34.4 %; <em>p</em> < 0.0001) and overall was higher in males (33.2 %) than females (21.3 %). Compared with those in the lowest quintile of plasma DHA % or Other n-3 PUFA %, the MVOR (95 % CI) for hearing difficulty was 0.88 (0.85, 0.92) in highest quintile of plasma DHA %, and 0.91 (0.87, 0.94) in the highest quintile of Other n-3 PUFA %. The associations with DHA % did not differ by age or sex (p-for-interaction 0.83 and 0.58, respectively). MVORs for DHA % and Other n-3 PUFA % were similar among the 44,486 individuals with data on noise exposure at work.</div></div><div><h3>Conclusions</h3><div>Higher plasma n-3 PUFA levels were independently associated with lower odds of hearing difficulty.</div></div>","PeriodicalId":94179,"journal":{"name":"Prostaglandins, leukotrienes, and essential fatty acids","volume":"203 ","pages":"Article 102654"},"PeriodicalIF":3.0000,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Cross-sectional analysis of plasma n-3 fatty acid levels and self-reported hearing difficulty in the UK Biobank Cohort\",\"authors\":\"Michael I. McBurney , Nathan L. Tintle , Jason Westra , William S. Harris , Sharon E. Curhan\",\"doi\":\"10.1016/j.plefa.2024.102654\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>Disabling hearing loss affects ∼430 million people globally. Fish consumption and long-chain n-3 polyunsaturated fatty acid (PUFA) intake were inversely associated with risk of hearing loss, but the association of plasma n-3 PUFAs and hearing loss is unclear.</div></div><div><h3>Objective</h3><div>To examine the associations between plasma n-3 PUFA fractions (as % of total fatty acids), i.e., DHA % and Other n-3 PUFA % (defined as total n-3 PUFA minus DHA), with self-reported hearing difficulty in a population-based cohort in the UK.</div></div><div><h3>Methods</h3><div>Our study includes 175,177 UK Biobank participants (40–69y, 54 % women) with data on plasma n-3 PUFA and hearing status. Baseline plasma PUFA levels were analyzed by nuclear magnetic resonance, and self-reported hearing difficulty was obtained by questionnaire between 2007 and 2010. Logistic regression was used to estimate age-adjusted odds ratios (ORs), multivariable-adjusted odds ratios (MVORs) by adjusting for 14 demographic, behavioral, biomarker and health-related potential confounders, and 95 % confidence intervals (CIs).</div></div><div><h3>Results</h3><div>Hearing difficulty was reported by 26.7 % of participants. Higher plasma n-3 PUFA levels were independently associated with lower odds of self-reported hearing difficulty. The prevalence of hearing difficulty rose across age strata (40–49y, 15.8 %; 50–59y, 24.9 % and 60+<em>y</em>, 34.4 %; <em>p</em> < 0.0001) and overall was higher in males (33.2 %) than females (21.3 %). Compared with those in the lowest quintile of plasma DHA % or Other n-3 PUFA %, the MVOR (95 % CI) for hearing difficulty was 0.88 (0.85, 0.92) in highest quintile of plasma DHA %, and 0.91 (0.87, 0.94) in the highest quintile of Other n-3 PUFA %. The associations with DHA % did not differ by age or sex (p-for-interaction 0.83 and 0.58, respectively). MVORs for DHA % and Other n-3 PUFA % were similar among the 44,486 individuals with data on noise exposure at work.</div></div><div><h3>Conclusions</h3><div>Higher plasma n-3 PUFA levels were independently associated with lower odds of hearing difficulty.</div></div>\",\"PeriodicalId\":94179,\"journal\":{\"name\":\"Prostaglandins, leukotrienes, and essential fatty acids\",\"volume\":\"203 \",\"pages\":\"Article 102654\"},\"PeriodicalIF\":3.0000,\"publicationDate\":\"2024-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Prostaglandins, leukotrienes, and essential fatty acids\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0952327824000486\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Prostaglandins, leukotrienes, and essential fatty acids","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0952327824000486","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

摘要

背景全球有 4.3 亿人患有致残性听力损失。鱼类摄入量和长链 n-3 多不饱和脂肪酸 (PUFA) 摄入量与听力损失风险成反比，但血浆 n-3 PUFA 与听力损失的关系尚不清楚、我们的研究包括 175,177 名英国生物库参与者（40-69 岁，54% 为女性），他们都提供了血浆 n-3 PUFA 和听力状况的数据。通过核磁共振分析了血浆 PUFA 的基线水平，并在 2007 年至 2010 年期间通过问卷调查获得了听力困难的自我报告。采用逻辑回归法估算了年龄调整后的几率比（ORs）、多变量调整后的几率比（MVORs）（调整了 14 个人口统计学、行为学、生物标志物和健康相关的潜在混杂因素）以及 95% 的置信区间（CIs）。较高的血浆 n-3 PUFA 水平与较低的自我报告听力困难几率独立相关。不同年龄段的听力障碍发生率均有所上升（40-49 岁，15.8%；50-59 岁，24.9%；60 岁以上，34.4%；p < 0.0001），男性（33.2%）的听力障碍发生率总体高于女性（21.3%）。与血浆 DHA % 或其他 n-3 PUFA % 最低五分位数的人群相比，血浆 DHA % 最高五分位数人群的听力困难 MVOR（95 % CI）为 0.88（0.85，0.92），其他 n-3 PUFA % 最高五分位数人群的听力困难 MVOR 为 0.91（0.87，0.94）。年龄或性别与 DHA 百分比的关系没有差异（交互作用 p 分别为 0.83 和 0.58）。在有工作噪音暴露数据的 44,486 人中，DHA % 和其他 n-3 PUFA % 的 MVORs 相似。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

Cross-sectional analysis of plasma n-3 fatty acid levels and self-reported hearing difficulty in the UK Biobank Cohort

Background

Disabling hearing loss affects ∼430 million people globally. Fish consumption and long-chain n-3 polyunsaturated fatty acid (PUFA) intake were inversely associated with risk of hearing loss, but the association of plasma n-3 PUFAs and hearing loss is unclear.

Objective

To examine the associations between plasma n-3 PUFA fractions (as % of total fatty acids), i.e., DHA % and Other n-3 PUFA % (defined as total n-3 PUFA minus DHA), with self-reported hearing difficulty in a population-based cohort in the UK.

Methods

Our study includes 175,177 UK Biobank participants (40–69y, 54 % women) with data on plasma n-3 PUFA and hearing status. Baseline plasma PUFA levels were analyzed by nuclear magnetic resonance, and self-reported hearing difficulty was obtained by questionnaire between 2007 and 2010. Logistic regression was used to estimate age-adjusted odds ratios (ORs), multivariable-adjusted odds ratios (MVORs) by adjusting for 14 demographic, behavioral, biomarker and health-related potential confounders, and 95 % confidence intervals (CIs).

Results

Hearing difficulty was reported by 26.7 % of participants. Higher plasma n-3 PUFA levels were independently associated with lower odds of self-reported hearing difficulty. The prevalence of hearing difficulty rose across age strata (40–49y, 15.8 %; 50–59y, 24.9 % and 60+y, 34.4 %; p < 0.0001) and overall was higher in males (33.2 %) than females (21.3 %). Compared with those in the lowest quintile of plasma DHA % or Other n-3 PUFA %, the MVOR (95 % CI) for hearing difficulty was 0.88 (0.85, 0.92) in highest quintile of plasma DHA %, and 0.91 (0.87, 0.94) in the highest quintile of Other n-3 PUFA %. The associations with DHA % did not differ by age or sex (p-for-interaction 0.83 and 0.58, respectively). MVORs for DHA % and Other n-3 PUFA % were similar among the 44,486 individuals with data on noise exposure at work.