帕金森病患者的步速和大脑网络连接发生改变

IF 2.9 2区 医学 Q2 NEUROSCIENCES Cerebral cortex Pub Date : 2024-11-05 DOI:10.1093/cercor/bhae429
Shichan Wang, Yi Xiao, Yanbing Hou, Chunyu Li, Junyu Lin, Tianmi Yang, Ningning Che, Qirui Jiang, Xiaoting Zheng, Jiyong Liu, Huifang Shang
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引用次数: 0

摘要

帕金森病(PD)患者普遍存在步速缓慢和大脑网络连接紊乱的问题。本研究旨在阐明帕金森病步态速度与临床特征之间的关系,并探索其潜在的脑网络机制。研究招募了42名帕金森病患者和20名健康对照组(HC)。采用独立成分统计分析和相关分析来研究潜在的神经机制和关系。帕金森病患者的步速明显减慢,与姿势不稳定性和步态障碍评分呈显著负相关。网络连通性分析显示,与高危人群相比,帕金森氏症患者的视觉网络(VN)和小脑网络(CN)内网络功能连通性(FC)降低,但CN与感觉运动网络(SMN)和顶额叶网络(FPN)之间的网络功能连通性(FC)增加。步速缓慢的帕金森氏症亚组显示,SMN和VN内部网络FC增加,而VN与FPN和默认模式网络之间的FC减少。相关性分析表明,步速与CN的FC呈负相关,与CN-SMN的FC呈正相关。我们的研究确定了步速与临床特征之间的关系,以及帕金森病患者相应的网络连接改变,为了解帕金森病步态障碍的神经机制提供了见解。
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Altered gait speed and brain network connectivity in Parkinson's disease.

Slow gait speed and disrupted brain network connectivity are common in patients with Parkinson's disease (PD). This study aimed to clarify the relationship between gait speed and clinical characteristics in PD, and explore the underlying brain network mechanisms. Forty-two PD patients and 20 healthy controls (HC) were recruited. Statistical independent component analysis and correlation analysis were employed to investigate underlying neural mechanisms and relationships. PD patients exhibited significantly slower gait speed, which showed a significant negative correlation with postural instability and gait disturbance scores. Network connectivity analysis revealed decreased intranetwork functional connectivity (FC) within visual network (VN) and cerebellum network (CN), but increased internetwork FC between CN and both sensorimotor network (SMN) and frontoparietal network (FPN) in PD patients compared to HC. The slow gait speed PD subgroup demonstrated increased intranetwork FC within SMN and VN, along with decreased FC between VN and both FPN and default mode network. Correlation analyses revealed negative correlation between gait speed and FC of CN and positive correlation to FC of CN-SMN. Our study identified relationships between gait speed and clinical characteristics, and corresponding network connectivity alterations in PD patients, providing insights into the neural mechanisms underlying gait impairments in PD.

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来源期刊
Cerebral cortex
Cerebral cortex 医学-神经科学
CiteScore
6.30
自引率
8.10%
发文量
510
审稿时长
2 months
期刊介绍: Cerebral Cortex publishes papers on the development, organization, plasticity, and function of the cerebral cortex, including the hippocampus. Studies with clear relevance to the cerebral cortex, such as the thalamocortical relationship or cortico-subcortical interactions, are also included. The journal is multidisciplinary and covers the large variety of modern neurobiological and neuropsychological techniques, including anatomy, biochemistry, molecular neurobiology, electrophysiology, behavior, artificial intelligence, and theoretical modeling. In addition to research articles, special features such as brief reviews, book reviews, and commentaries are included.
期刊最新文献
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