早期间歇性接触胆固醇会加速动脉粥样硬化：振荡放大器需要预先控制

IF 40.8 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Signal Transduction and Targeted Therapy Pub Date : 2024-11-07 DOI:10.1038/s41392-024-02032-7

Maria Kral, Yvonne Döring, Christian Weber

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引用次数: 0

摘要

最近发表在《自然》（Nature）1 上的一篇文章指出，早期间歇性高脂血症是动脉粥样硬化的一个新的决定因素，它导致动脉驻留巨噬细胞的表型发生改变，自噬和排泄相关途径出现缺陷。这些耐人寻味的发现推断，有必要在年轻时就预先控制胆固醇，以预防和限制动脉粥样硬化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Early intermittent cholesterol exposure accelerates atherosclerosis: an oscillating amplifier calling for preemptive control

A recent publication in Nature¹ identified early intermittent hyperlipidemia as a new determinant of atherosclerosis driving an altered phenotype of arterial-resident macrophages with defects in autophagy- and efferocytosis-related pathways. These intriguing findings infer the need for preemptive control of cholesterol already at younger age to prevent and limit atherosclerosis.

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来源期刊

Signal Transduction and Targeted Therapy Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

44.50

自引率

1.50%

发文量

384

审稿时长

5 weeks

期刊介绍： Signal Transduction and Targeted Therapy is an open access journal that focuses on timely publication of cutting-edge discoveries and advancements in basic science and clinical research related to signal transduction and targeted therapy. Scope: The journal covers research on major human diseases, including, but not limited to: Cancer,Cardiovascular diseases,Autoimmune diseases,Nervous system diseases.