氧化铁纳米粒子的简易合成及其生物活性评估†

IF 3.9 3区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY RSC Advances Pub Date : 2024-11-11 DOI:10.1039/D4RA05024J
Erum Hasan, Ziana Manzar, Nabeel Haroon, Ali Raza, Syed Nawazish Ali, Mehreen Lateef and Sabira Begum
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引用次数: 0

摘要

一种用 3-氨基苯甲酸(3-ABA)包裹的 pH 值稳定的磁性纳米传感器(氧化铁纳米粒子,Fe-NPs,2.6 nm 以下)的快速合成已经实现。3-ABA 首次是在盐酸和锡存在下通过还原 3-硝基苯甲酸(3-NBA)制备的。在表征过程中使用了电子碰撞质谱(EIMS)、傅立叶变换红外光谱(FTIR)、核磁共振(NMR)、紫外可见光谱(UV)和原子力显微镜(AFM)。对环丙沙星(CPF)、左西替利嗪(LCT)、左氧氟沙星(LVF)、舒巴坦钠(SBS)、麻黄碱(EPH)、胸腺嘧啶(THM)、舍曲林(SRT)、吡哆醇(PRX)、头孢他啶(CFX)和头孢曲松(CFT)这十种药物与 Fe-NPs 进行了筛选。观察到左氧氟沙星和环丙沙星出现了明显的低色移,证明 3-ABA 包覆的 Fe-NPs 是一种高效的左氧氟沙星和环丙沙星纳米传感器,其极限分别为 0.5 和 0.7 μM。利用约伯图分析法确定了复合物的化学计量为 1 :1 的比例。此外,还成功地在自来水、井水和人体血液等实际样品中检测到了这些药物。此外,还对这些纳米颗粒的抗氧化活性、脲酶和脂氧合酶抑制潜力进行了评估,结果表明它们具有良好的抗氧化潜力。
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A facile synthesis of iron oxide nanoparticles as a nano-sensor to detect levofloxacin and ciprofloxacin in human blood and evaluation of their biological activities†

A rapid synthesis of a pH-stable magnetic nano-sensor (iron oxide nanoparticles, Fe-NPs, ∼2.6 nm) encapsulated with 3-aminobenzoic acid (3-ABA) was achieved. 3-ABA was prepared for the first time through the reduction of 3-nitrobenzoic acid (3-NBA) in the presence of HCl and tin. Electron-impact mass spectrometry (EIMS), Fourier-transform infrared (FTIR), nuclear magnetic resonance (NMR), ultraviolet visible (UV) spectroscopy and atomic force microscopy (AFM) were used for characterization. Ten drugs, namely, ciprofloxacin (CPF), levocetirizine (LCT), levofloxacin (LVF), sulbactam sodium (SBS), ephedrine (EPH), thymine (THM), sertraline (SRT), pyridoxine (PRX), cefotaxime (CFX) and ceftriaxone (CFT) were screened with Fe-NPs. A pronounced hypsochromic shift was observed for levofloxacin and ciprofloxacin, proving that 3-ABA-coated Fe-NPs were an efficient nano-sensor for levofloxacin and ciprofloxacin up to the limit of 0.5 and 0.7 μM, respectively. The stoichiometry of the complexes was conclusively determined as 1 : 1 using Job's plot analysis. Furthermore, the drugs were successfully detected in real samples, including tap water, well water, and human blood. Moreover, the antioxidant activity, urease and lipoxygenase inhibitory potential of these nanoparticles were evaluated, exhibiting promising antioxidant potential.

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来源期刊
RSC Advances
RSC Advances chemical sciences-
CiteScore
7.50
自引率
2.60%
发文量
3116
审稿时长
1.6 months
期刊介绍: An international, peer-reviewed journal covering all of the chemical sciences, including multidisciplinary and emerging areas. RSC Advances is a gold open access journal allowing researchers free access to research articles, and offering an affordable open access publishing option for authors around the world.
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